KEGG   DRUG: CarvedilolHelp
Entry
D00255                      Drug                                   

Name
Carvedilol (JAN/USAN/INN);
Artist (TN);
Coreg (TN)
Product
  Generic
CARVEDILOL (A-S Medication Solutions), CARVEDILOL (A-S Medication Solutions), CARVEDILOL (ACETRIS HEALTH), CARVEDILOL (Aidarex Pharmaceuticals LLC), CARVEDILOL (Aidarex Pharmaceuticals LLC), CARVEDILOL (American Health Packaging), CARVEDILOL (Aphena Pharma Solutions - Tennessee), CARVEDILOL (Aphena Pharma Solutions - Tennessee), CARVEDILOL (Aurobindo Pharma Limited), CARVEDILOL (Aurolife Pharma LLC), CARVEDILOL (Avera McKennan Hospital), CARVEDILOL (Avera McKennan Hospital), CARVEDILOL (Avera McKennan Hospital), CARVEDILOL (Avera McKennan Hospital), CARVEDILOL (Bayshore Pharmaceuticals LLC), CARVEDILOL (Blenheim Pharmacal), CARVEDILOL (BluePoint Laboratories), CARVEDILOL (Bryant Ranch Prepack), CARVEDILOL (Bryant Ranch Prepack), CARVEDILOL (Bryant Ranch Prepack), CARVEDILOL (Bryant Ranch Prepack), CARVEDILOL (Bryant Ranch Prepack), CARVEDILOL (Bryant Ranch Prepack), CARVEDILOL (Bryant Ranch Prepack), CARVEDILOL (Bryant Ranch Prepack), CARVEDILOL (Bryant Ranch Prepack), CARVEDILOL (Cadila Healthcare Limited), CARVEDILOL (Cardinal Health), CARVEDILOL (Cardinal Health), CARVEDILOL (Cipla USA), CARVEDILOL (Clinical Solutions Wholesale), CARVEDILOL (DIRECT RX), CARVEDILOL (DIRECT RX), CARVEDILOL (Dr. Reddy's Laboratories Limited), CARVEDILOL (Glenmark Pharmaceuticals), CARVEDILOL (Golden State Medical Supply), CARVEDILOL (H.J. Harkins Company), CARVEDILOL (H.J. Harkins Company), CARVEDILOL (Lake Erie Medical DBA Quality Care Products LLC), CARVEDILOL (Lake Erie Medical DBA Quality Care Products LLC), CARVEDILOL (Lake Erie Medical DBA Quality Care Products LLC), CARVEDILOL (Lake Erie Medical DBA Quality Care Products LLC), CARVEDILOL (Legacy Pharmaceutical Packaging), CARVEDILOL (Legacy Pharmaceutical Packaging), CARVEDILOL (Major Pharmaceuticals), CARVEDILOL (Marlex Pharmaceuticals), CARVEDILOL (MedVantx), CARVEDILOL (MedVantx), CARVEDILOL (Mylan Institutional), CARVEDILOL (Mylan Pharmaceuticals), CARVEDILOL (NCS HealthCare of KY), CARVEDILOL (NCS HealthCare of KY), CARVEDILOL (Northwind Pharmaceuticals), CARVEDILOL (Northwind Pharmaceuticals), CARVEDILOL (NuCare Pharmaceutical), CARVEDILOL (NuCare Pharmaceuticals), CARVEDILOL (NuCare Pharmaceuticals), CARVEDILOL (NuCare Pharmaceuticals), CARVEDILOL (NuCare Pharmaceuticals), CARVEDILOL (NuCare Pharmaceuticals), CARVEDILOL (NuCare Pharmaceuticals), CARVEDILOL (NuCare Pharmaceuticals), CARVEDILOL (NuCare Pharmaceuticals), CARVEDILOL (PD-Rx Pharmaceuticals), CARVEDILOL (PD-Rx Pharmaceuticals), CARVEDILOL (PD-Rx Pharmaceuticals), CARVEDILOL (PD-Rx Pharmaceuticals), CARVEDILOL (Physicians Total Care), CARVEDILOL (Preferred Pharmaceuticals), CARVEDILOL (Preferred Pharmaceuticals), CARVEDILOL (Preferred Pharmaceuticals), CARVEDILOL (Preferred Pharmaceuticals), CARVEDILOL (Preferred Pharmaceuticals), CARVEDILOL (Preferred Pharmaceuticals), CARVEDILOL (Proficient Rx LP), CARVEDILOL (Proficient Rx LP), CARVEDILOL (Proficient Rx LP), CARVEDILOL (Proficient Rx LP), CARVEDILOL (Proficient Rx LP), CARVEDILOL (Proficient Rx LP), CARVEDILOL (QPharma), CARVEDILOL (REMEDYREPACK), CARVEDILOL (REMEDYREPACK), CARVEDILOL (REMEDYREPACK), CARVEDILOL (REMEDYREPACK), CARVEDILOL (REMEDYREPACK), CARVEDILOL (REMEDYREPACK), CARVEDILOL (REMEDYREPACK), CARVEDILOL (REMEDYREPACK), CARVEDILOL (REMEDYREPACK), CARVEDILOL (REMEDYREPACK), CARVEDILOL (REMEDYREPACK), CARVEDILOL (REMEDYREPACK), CARVEDILOL (REMEDYREPACK), CARVEDILOL (REMEDYREPACK), CARVEDILOL (REMEDYREPACK), CARVEDILOL (REMEDYREPACK), CARVEDILOL (REMEDYREPACK), CARVEDILOL (REMEDYREPACK), CARVEDILOL (Rebel Distributors Corp), CARVEDILOL (RedPharm Drug), CARVEDILOL (Sandoz), CARVEDILOL (Solco Healthcare US LLC), CARVEDILOL (St Marys Medical Park Pharmacy), CARVEDILOL (St. Mary's Medical Park Pharmacy), CARVEDILOL (St. Mary's Medical Park Pharmacy), CARVEDILOL (St. Mary's Medical Park Pharmacy), CARVEDILOL (State of Florida DOH Central Pharmacy), CARVEDILOL (State of Florida DOH Central Pharmacy), CARVEDILOL (State of Florida DOH Central Pharmacy), CARVEDILOL (State of Florida DOH Central Pharmacy), CARVEDILOL (State of Florida DOH Central Pharmacy), CARVEDILOL (Sun Pharmaceutical Industries), CARVEDILOL (Teva Pharmaceuticals USA), CARVEDILOL (Unit Dose Services), CARVEDILOL (Unit Dose Services), CARVEDILOL (Unit Dose Services), CARVEDILOL (Unit Dose Services), CARVEDILOL (Unit Dose Services), CARVEDILOL (Unit Dose Services), CARVEDILOL (Zydus Pharmaceuticals (USA))
Formula
C24H26N2O4
Exact mass
406.1893
Mol weight
406.4742
Structure
Mol fileKCF fileDB searchJmolKegDraw
Simcomp SIMCOMP
Class
Cardiovascular agent
 DG01466  Adrenergic receptor antagonist
  DG01464  beta-Adrenergic receptor antagonist
   DG01461  beta1-Adrenergic receptor antagonist
   DG01462  beta2-Adrenergic receptor antagonist
   DG01463  beta3-Adrenergic receptor antagonist
  DG01465  alpha-Adrenergic receptor antagonist
   DG01457  alpha1-Adrenergic receptor antagonist
Cyp substrate
 DG01892  CYP1A2 substrate
 DG01644  CYP2D6 substrate
 DG01633  CYP3A substrate
Remark
Same as: C06875
Therapeutic category: 2149
ATC code: C07AG02
Chemical structure group: DG00321
Product (DG00321): D00255<JP/US> D03415<US>
Efficacy
Antihypertensive, alpha1/beta-Adrenergic receptor antagonist
  Disease
Hypertension [DS:H01633]
Target
ADRA1 [HSA:148 147 146] [KO:K04135 K04136 K04137]
ADRB1 [HSA:153] [KO:K04141]
ADRB2 [HSA:154] [KO:K04142]
  Pathway
hsa04020  Calcium signaling pathway
hsa04022  cGMP-PKG signaling pathway
hsa04024  cAMP signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04261  Adrenergic signaling in cardiomyocytes
hsa04270  Vascular smooth muscle contraction
hsa05414  Dilated cardiomyopathy (DCM)
Metabolism
Enzyme: CYP2D6 [HSA:1565], CYP2C9 [HSA:1559], CYP3A4 [HSA:1576], CYP1A2 [HSA:1544], CYP2E1 [HSA:1571]
Interaction
Transporter inhibition: ABCB1 [HSA:5243]
Drug interaction
Structure map
map07215  alpha-Adrenergic receptor agonists/antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 C CARDIOVASCULAR SYSTEM
  C07 BETA BLOCKING AGENTS
   C07A BETA BLOCKING AGENTS
    C07AG Alpha and beta blocking agents
     C07AG02 Carvedilol
      D00255  Carvedilol (JAN/USAN/INN) <JP/US>
USP drug classification [BR:br08302]
 Cardiovascular Agents
  Beta-adrenergic Blocking Agents
   Carvedilol
    D00255  Carvedilol (JAN/USAN/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  21  Cardiovascular agents
   214  Antihypertensives
    2149  Others
     D00255  Carvedilol (JAN/USAN/INN)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Adrenaline
    ADRA1
     D00255  Carvedilol (JAN/USAN/INN) <JP/US>
    ADRB1
     D00255  Carvedilol (JAN/USAN/INN) <JP/US>
    ADRB2
     D00255  Carvedilol (JAN/USAN/INN) <JP/US>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D00255  Carvedilol
  D00255  Carvedilol tablets
Drug classes of therapeutic agents [br08360.html]
 Cardiovascular agents
  D00255
Pharmacogenomic biomarkers in FDA drug labels [br08341.html]
 Polymorphisms and germline mutations
  D00255
BRITE hierarchy
Other DBs
CAS: 72956-09-3
PubChem: 7847321
ChEBI: 3441
ChEMBL: CHEMBL723
DrugBank: DB01136
LigandBox: D00255
NIKKAJI: J33.955E
KCF data Show

ATOM        30
            1   C8y C    17.5000  -16.5200
            2   C8y C    16.1700  -16.0300
            3   C8y C    17.5000  -17.9200
            4   C8y C    18.7600  -15.8200
            5   C8y C    15.3300  -17.1500
            6   C8x C    15.6800  -14.7000
            7   N4x N    16.1700  -18.3400
            8   C8x C    18.6900  -18.6200
            9   C8x C    19.9500  -16.5200
            10  O2a O    18.7600  -14.4200
            11  C8x C    13.9300  -16.9400
            12  C8x C    14.2800  -14.5600
            13  C8x C    19.9500  -17.9200
            14  C1b C    20.0200  -13.7200
            15  C8x C    13.4400  -15.6800
            16  C1c C    21.2100  -14.4900
            17  C1b C    22.4700  -13.7900
            18  O1a O    21.2100  -15.8900
            19  N1b N    23.5900  -14.5600
            20  C1b C    24.8500  -13.8600
            21  C1b C    26.0400  -14.5600
            22  O2a O    27.2300  -13.9300
            23  C8y C    28.4900  -14.6300
            24  C8y C    28.4900  -16.0300
            25  C8x C    29.6800  -14.0000
            26  C8x C    29.6100  -16.8000
            27  O2a O    27.2300  -16.6600
            28  C8x C    30.8700  -14.7000
            29  C8x C    30.8700  -16.1000
            30  C1a C    25.9700  -15.9600
BOND        33
            1     1   2 1
            2     1   3 2
            3     1   4 1
            4     2   5 2
            5     2   6 1
            6     3   7 1
            7     3   8 1
            8     4   9 2
            9     4  10 1
            10    5  11 1
            11    6  12 2
            12    8  13 2
            13   10  14 1
            14   11  15 2
            15   14  16 1
            16   16  17 1
            17   16  18 1
            18   17  19 1
            19   19  20 1
            20   20  21 1
            21   21  22 1
            22   22  23 1
            23   23  24 2
            24   23  25 1
            25   24  26 1
            26   24  27 1
            27   25  28 2
            28   26  29 2
            29   27  30 1
            30    5   7 1
            31    9  13 1
            32   12  15 1
            33   28  29 1

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