 | | DRUG: Carvedilol | |
| Entry |
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| Name |
Carvedilol (JP18/USP/INN);
Artist (TN);
Coreg (TN) |
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| Product |
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| Generic |
CARVEDILOL (A-S Medication Solutions), CARVEDILOL (A-S Medication Solutions), CARVEDILOL (A-S Medication Solutions), CARVEDILOL (A-S Medication Solutions), CARVEDILOL (A-S Medication Solutions), CARVEDILOL (A-S Medication Solutions), CARVEDILOL (A-S Medication Solutions), CARVEDILOL (A-S Medication Solutions), CARVEDILOL (A-S Medication Solutions), CARVEDILOL (A-S Medication Solutions), CARVEDILOL (A-S Medication Solutions), CARVEDILOL (A-S Medication Solutions), CARVEDILOL (Advagen Pharma), CARVEDILOL (American Health Packaging), CARVEDILOL (Aphena Pharma Solutions - Tennessee), CARVEDILOL (Aphena Pharma Solutions - Tennessee), CARVEDILOL (Aphena Pharma Solutions - Tennessee), CARVEDILOL (Aurobindo Pharma Limited), CARVEDILOL (Bayshore Pharmaceuticals LLC), CARVEDILOL (BluePoint Laboratories), CARVEDILOL (Bryant Ranch Prepack), CARVEDILOL (Bryant Ranch Prepack), CARVEDILOL (Bryant Ranch Prepack), CARVEDILOL (Bryant Ranch Prepack), CARVEDILOL (Bryant Ranch Prepack), CARVEDILOL (Bryant Ranch Prepack), CARVEDILOL (Bryant Ranch Prepack), CARVEDILOL (Bryant Ranch Prepack), CARVEDILOL (Bryant Ranch Prepack), CARVEDILOL (Bryant Ranch Prepack), CARVEDILOL (Bryant Ranch Prepack), CARVEDILOL (Cardinal Health 107), CARVEDILOL (Cardinal Health 107), CARVEDILOL (DIRECT RX), CARVEDILOL (DIRECT RX), CARVEDILOL (Direct_Rx), CARVEDILOL (Direct_Rx), CARVEDILOL (Direct_Rx), CARVEDILOL (Direct_Rx), CARVEDILOL (Direct_Rx), CARVEDILOL (Direct_Rx), CARVEDILOL (Direct_Rx), CARVEDILOL (Direct_Rx), CARVEDILOL (Dr. Reddy's Laboratories Limited), CARVEDILOL (Glenmark Pharmaceuticals), CARVEDILOL (Golden State Medical Supply), CARVEDILOL (Legacy Pharmaceutical Packaging), CARVEDILOL (Major Pharmaceuticals), CARVEDILOL (Mylan Institutional), CARVEDILOL (Mylan Pharmaceuticals), CARVEDILOL (NCS HealthCare of KY), CARVEDILOL (Northwind Pharmaceuticals), CARVEDILOL (Northwind Pharmaceuticals), CARVEDILOL (Northwind Pharmaceuticals), CARVEDILOL (Northwind Pharmaceuticals), CARVEDILOL (Northwind Pharmaceuticals), CARVEDILOL (Northwind Pharmaceuticals), CARVEDILOL (Northwind Pharmaceuticals), CARVEDILOL (NuCare Pharmaceuticals), CARVEDILOL (NuCare Pharmaceuticals), CARVEDILOL (NuCare Pharmaceuticals), CARVEDILOL (NuCare Pharmaceuticals), CARVEDILOL (NuCare Pharmaceuticals), CARVEDILOL (NuCare Pharmaceuticals), CARVEDILOL (NuCare Pharmaceuticals), CARVEDILOL (PD-Rx Pharmaceuticals), CARVEDILOL (PD-Rx Pharmaceuticals), CARVEDILOL (PD-Rx Pharmaceuticals), CARVEDILOL (PD-Rx Pharmaceuticals), CARVEDILOL (Preferred Pharmaceuticals Inc.,), CARVEDILOL (Preferred Pharmaceuticals), CARVEDILOL (Preferred Pharmaceuticals), CARVEDILOL (Preferred Pharmaceuticals), CARVEDILOL (Preferred Pharmaceuticals), CARVEDILOL (Preferred Pharmaceuticals), CARVEDILOL (Preferred Pharmaceuticals), CARVEDILOL (Preferred Pharmaceuticals), CARVEDILOL (Proficient Rx LP), CARVEDILOL (Proficient Rx LP), CARVEDILOL (Proficient Rx LP), CARVEDILOL (Proficient Rx LP), CARVEDILOL (Proficient Rx LP), CARVEDILOL (Proficient Rx LP), CARVEDILOL (QPharma), CARVEDILOL (QPharma), CARVEDILOL (Quallent Pharmaceuticals Health LLC), CARVEDILOL (REMEDYREPACK), CARVEDILOL (REMEDYREPACK), CARVEDILOL (REMEDYREPACK), CARVEDILOL (REMEDYREPACK), CARVEDILOL (REMEDYREPACK), CARVEDILOL (REMEDYREPACK), CARVEDILOL (REMEDYREPACK), CARVEDILOL (REMEDYREPACK), CARVEDILOL (REMEDYREPACK), CARVEDILOL (RPK Pharmaceuticals), CARVEDILOL (RPK Pharmaceuticals), CARVEDILOL (RPK Pharmaceuticals), CARVEDILOL (RedPharm Drug), CARVEDILOL (RedPharm Drug), CARVEDILOL (RedPharm Drug), CARVEDILOL (RedPharm Drug), CARVEDILOL (ST. MARY'S MEDICAL PARK PHARMACY), CARVEDILOL (Sandoz), CARVEDILOL (St. Mary's Medical Park Pharmacy), CARVEDILOL (St. Mary's Medical Park Pharmacy), CARVEDILOL (St. Mary's Medical Park Pharmacy), CARVEDILOL (St. Mary's Medical Park Pharmacy), CARVEDILOL (Teva Pharmaceuticals USA), CARVEDILOL (Zydus Lifesciences Limited), CARVEDILOL (Zydus Pharmaceuticals USA) |
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| Formula |
C24H26N2O4
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| Exact mass |
406.1893
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| Mol weight |
406.4742
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| Structure |
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| Simcomp |
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| Class |
Cardiovascular agent
DG01466 Adrenergic receptor antagonist
DG03180 alpha1 and beta-Adrenergic receptor antagonist
DG03231 Antihypertensive
DG03180 alpha1 and beta-Adrenergic receptor antagonist
Metabolizing enzyme substrate
DG01892 CYP1A2 substrate
DG01642 CYP2C9 substrate
DG01644 CYP2D6 substrate
DG02855 CYP2E1 substrate
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
Transporter inhibitor
DG01622 ABCB1 inhibitor
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| Remark |
| Therapeutic category: | 2149 |
| Product (DG00321): | D00255<JP/US> D03415<US> |
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| Efficacy |
Antihypertensive, alpha1/beta-Adrenergic receptor antagonist |
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| Disease |
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| Target |
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| Pathway |
| hsa04080 | Neuroactive ligand-receptor interaction |
| hsa04261 | Adrenergic signaling in cardiomyocytes |
| hsa04270 | Vascular smooth muscle contraction |
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| Metabolism |
Enzyme: CYP2D6 [HSA: 1565], CYP2C9 [HSA: 1559], CYP3A4 [HSA: 1576], CYP1A2 [HSA: 1544], CYP2E1 [HSA: 1571]
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| Interaction |
Transporter inhibition: ABCB1 [HSA: 5243]
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| Structure map |
| map07215 | alpha-Adrenergic receptor agonists/antagonists |
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| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
C CARDIOVASCULAR SYSTEM
C07 BETA BLOCKING AGENTS
C07A BETA BLOCKING AGENTS
C07AG Alpha and beta blocking agents
C07AG02 Carvedilol
D00255 Carvedilol (JP18/USP/INN) <JP/US>
USP drug classification [BR:br08302]
Cardiovascular Agents
Beta-adrenergic Blocking Agents
Beta-adrenergic Blocking Agents, Other
Carvedilol
D00255 Carvedilol (JP18/USP/INN)
Therapeutic category of drugs in Japan [BR:br08301]
2 Agents affecting individual organs
21 Cardiovascular agents
214 Antihypertensives
2149 Others
D00255 Carvedilol (JP18/USP/INN)
Drug groups [BR:br08330]
Cardiovascular agent
DG01466 Adrenergic receptor antagonist
DG03180 alpha1 and beta-Adrenergic receptor antagonist
DG00321 Carvedilol
D00255 Carvedilol
DG03231 Antihypertensive
DG03180 alpha1 and beta-Adrenergic receptor antagonist
DG00321 Carvedilol
D00255 Carvedilol
Metabolizing enzyme substrate
DG01892 CYP1A2 substrate
DG00321 Carvedilol
D00255 Carvedilol
DG01642 CYP2C9 substrate
DG00321 Carvedilol
D00255 Carvedilol
DG01644 CYP2D6 substrate
DG00321 Carvedilol
D00255 Carvedilol
DG02855 CYP2E1 substrate
DG00321 Carvedilol
D00255 Carvedilol
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
DG00321 Carvedilol
D00255 Carvedilol
Transporter inhibitor
DG01622 ABCB1 inhibitor
DG00321 Carvedilol
D00255 Carvedilol
Drug classes [BR:br08332]
Cardiovascular agent
DG03231 Antihypertensive
D00255 Carvedilol
Target-based classification of drugs [BR:br08310]
G Protein-coupled receptors
Rhodopsin family
Adrenaline
ADRA1
D00255 Carvedilol (JP18/USP/INN) <JP/US>
ADRB1
D00255 Carvedilol (JP18/USP/INN) <JP/US>
ADRB2
D00255 Carvedilol (JP18/USP/INN) <JP/US>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
Chemicals
D00255 Carvedilol
D00255 Carvedilol tablets
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D00255
Drug transporters
D00255
Pharmacogenomic biomarkers [br08341.html]
Polymorphisms and mutations affecting drug response
D00255
Drug groups [BR:br08330]
Cardiovascular agent
DG01466 Adrenergic receptor antagonist
DG03180 alpha1 and beta-Adrenergic receptor antagonist
DG00321 Carvedilol
DG03231 Antihypertensive
DG03180 alpha1 and beta-Adrenergic receptor antagonist
DG00321 Carvedilol
Metabolizing enzyme substrate
DG01892 CYP1A2 substrate
DG00321 Carvedilol
DG01642 CYP2C9 substrate
DG00321 Carvedilol
DG01644 CYP2D6 substrate
DG00321 Carvedilol
DG02855 CYP2E1 substrate
DG00321 Carvedilol
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
DG00321 Carvedilol
Transporter inhibitor
DG01622 ABCB1 inhibitor
DG00321 Carvedilol
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| Other DBs |
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| KCF data |
ATOM 30
1 C8y C 17.5000 -16.5200
2 C8y C 16.1700 -16.0300
3 C8y C 17.5000 -17.9200
4 C8y C 18.7600 -15.8200
5 C8y C 15.3300 -17.1500
6 C8x C 15.6800 -14.7000
7 N4x N 16.1700 -18.3400
8 C8x C 18.6900 -18.6200
9 C8x C 19.9500 -16.5200
10 O2a O 18.7600 -14.4200
11 C8x C 13.9300 -16.9400
12 C8x C 14.2800 -14.5600
13 C8x C 19.9500 -17.9200
14 C1b C 20.0200 -13.7200
15 C8x C 13.4400 -15.6800
16 C1c C 21.2100 -14.4900
17 C1b C 22.4700 -13.7900
18 O1a O 21.2100 -15.8900
19 N1b N 23.5900 -14.5600
20 C1b C 24.8500 -13.8600
21 C1b C 26.0400 -14.5600
22 O2a O 27.2300 -13.9300
23 C8y C 28.4900 -14.6300
24 C8y C 28.4900 -16.0300
25 C8x C 29.6800 -14.0000
26 C8x C 29.6100 -16.8000
27 O2a O 27.2300 -16.6600
28 C8x C 30.8700 -14.7000
29 C8x C 30.8700 -16.1000
30 C1a C 25.9700 -15.9600
BOND 33
1 1 2 1
2 1 3 2
3 1 4 1
4 2 5 2
5 2 6 1
6 3 7 1
7 3 8 1
8 4 9 2
9 4 10 1
10 5 11 1
11 6 12 2
12 8 13 2
13 10 14 1
14 11 15 2
15 14 16 1
16 16 17 1
17 16 18 1
18 17 19 1
19 19 20 1
20 20 21 1
21 21 22 1
22 22 23 1
23 23 24 2
24 23 25 1
25 24 26 1
26 24 27 1
27 25 28 2
28 26 29 2
29 27 30 1
30 5 7 1
31 9 13 1
32 12 15 1
33 28 29 1
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