| Entry |
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| Name |
Chlorpromazine (USP/INN);
Thorazine (TN)
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| Formula |
C17H19ClN2S
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| Exact mass |
318.0957
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| Mol weight |
318.8642
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| Structure |
     |
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| Activity |
Anti-emetic;
Antipsychotic
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| Remark |
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| Comment |
Phenothiazine derivatives
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| Target |
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| Pathway |
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| Metabolism |
Enzyme: CYP2D6 [HSA: 1565]
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| Interaction |
CYP inhibition: CYP2D6 [HSA: 1565]
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| Structure map |
| Antipsychotics | | Phenothiazines | | Antimigraines | | Histamine H1 receptor antagonists | | Dopamine receptor agonists/antagonists |
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| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
N NERVOUS SYSTEM
N05 PSYCHOLEPTICS
N05A ANTIPSYCHOTICS
N05AA Phenothiazines with aliphatic side-chain
N05AA01 Chlorpromazine
D00270 Chlorpromazine (USP/INN)
USP drug classification [BR:br08302]
Antiemetics
Antiemetics, Other
Chlorpromazine
D00270 Chlorpromazine (USP/INN)
Antipsychotics
1st Generation/Typical
Chlorpromazine
D00270 Chlorpromazine (USP/INN)
Target-based classification of drugs [BR:br08310]
G Protein-coupled receptors
Rhodopsin family
Acetylcholine (muscarinic)
muscarinic cholinergic receptor [HSA:1128 1129 1131 1132 1133] [KO:K04129 K04130 K04131 K04132 K04133]
Chlorpromazine [ATC:N05AA01]
D00270 Chlorpromazine (USP/INN)
Adrenaline
alpha2-adrenergic receptor [HSA:150 151 152] [KO:K04138 K04139 K04140]
Chlorpromazine [ATC:N05AA01]
D00270 Chlorpromazine (USP/INN)
Dopamine
dopamine D2-receptor [HSA:1813] [KO:K04145]
Chlorpromazine [ATC:N05AA01]
D00270 Chlorpromazine (USP/INN)
Histamine
H1-receptor [HSA:3269] [KO:K04149]
Chlorpromazine [ATC:N05AA01]
D00270 Chlorpromazine (USP/INN)
Serotonin
5-HT2-receptor [HSA:3356 3357 3358] [KO:K04157]
Chlorpromazine [ATC:N05AA01]
D00270 Chlorpromazine (USP/INN)
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| Other DBs |
CAS: 50-53-3 PubChem: DrugBank: PDB-CCD: LigandBox: NIKKAJI: |
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| KCF data |
ATOM 21
1 C8x C 3.4300 -16.7300
2 C8x C 3.4300 -18.1300
3 C8x C 4.6424 -18.8300
4 C8y C 5.8549 -18.1300
5 C8y C 5.8549 -16.7300
6 C8x C 4.6424 -16.0300
7 S2x S 7.0673 -18.8300
8 C8y C 8.2797 -18.1300
9 C8y C 8.2797 -16.7300
10 N4y N 7.0673 -16.0300
11 C8x C 9.4922 -18.8300
12 C8x C 10.7046 -18.1300
13 C8y C 10.7046 -16.7300
14 C8x C 9.4922 -16.0300
15 C1b C 7.0673 -14.6300
16 C1b C 8.2818 -13.9288
17 C1b C 9.4783 -14.6198
18 N1c N 10.6651 -13.9346
19 C1a C 11.8566 -14.6228
20 C1a C 10.6653 -12.5302
21 X Cl 11.9211 -16.0277
BOND 23
1 1 2 2
2 2 3 1
3 3 4 2
4 4 5 1
5 5 6 2
6 1 6 1
7 4 7 1
8 7 8 1
9 8 9 1
10 9 10 1
11 5 10 1
12 8 11 2
13 11 12 1
14 12 13 2
15 13 14 1
16 9 14 2
17 10 15 1
18 15 16 1
19 16 17 1
20 17 18 1
21 18 19 1
22 18 20 1
23 13 21 1
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