KEGG   DRUG: D00274Help
Entry
D00274                      Drug                                   

Name
Cisapride (USAN/INN)
Formula
C23H29ClFN3O4
Exact mass
465.1831
Mol weight
465.9455
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Stimulant [peristaltic]
Remark
Same as: 
ATC code: 
Drug group: 
Target
5-HT4-receptor agonist [HSA:3360] [KO:K04160]
  Pathway
hsa04020  Calcium signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04726  Serotonergic synapse  
 
Metabolism
Enzyme: CYP3A4 [HSA:1576], CYP3A5 [HSA:1577], CYP3A7 [HSA:1551]
Interaction
Drug interaction
Structure map
Serotonin receptor agonists/antagonists
Dopamine receptor agonists/antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 A ALIMENTARY TRACT AND METABOLISM
  A03 DRUGS FOR FUNCTIONAL GASTROINTESTINAL DISORDERS
   A03F PROPULSIVES
    A03FA Propulsives
     A03FA02 Cisapride
      D00274  Cisapride (USAN/INN)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Serotonin
    5-HT4-receptor
     Cisapride
      D00274  Cisapride (USAN/INN)
Cytochrome P450 interactions [BR:br08309]
 Substrates
  CYP3A4
   Cisapride
    D00274  Cisapride (USAN/INN)
  CYP3A5
   Cisapride
    D00274  Cisapride (USAN/INN)
  CYP3A7
   Cisapride
    D00274  Cisapride (USAN/INN)
BRITE hierarchy
Other DBs
CAS: 
81098-60-4
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        32
            1   C5a C    20.0892  -18.1293
            2   N1b N    21.3492  -17.4293
            3   O5a O    20.0892  -19.5292
            4   C1y C    22.5391  -18.1293
            5   C1y C    22.5391  -19.5292
            6   C1x C    23.7291  -17.4293
            7   C1x C    23.7291  -20.2292
            8   O2a O    21.2792  -20.2292
            9   C1x C    24.9191  -18.1293
            10  N1y N    24.9191  -19.5292
            11  C1a C    21.2792  -21.6291
            12  C1b C    26.1090  -20.2992
            13  C1b C    27.3690  -19.5992
            14  C1b C    28.5589  -20.2992
            15  O2a O    29.7489  -19.5992
            16  C8y C    31.0088  -20.2992
            17  C8x C    31.0088  -21.6991
            18  C8x C    32.1988  -19.5992
            19  C8x C    32.1988  -22.3991
            20  C8x C    33.3888  -20.3692
            21  C8y C    33.3888  -21.7691
            22  X   F    34.6487  -22.4691
            23  C8y C    18.8827  -17.4193
            24  C8y C    18.8943  -16.0293
            25  C8x C    17.6877  -15.3193
            26  C8y C    16.4696  -16.0091
            27  C8y C    16.4580  -17.3991
            28  C8x C    17.6645  -18.1092
            29  N1a N    15.2572  -15.2955
            30  X   Cl   15.2203  -18.0996
            31  O2a O    20.1162  -15.3374
            32  C1a C    21.2991  -16.0336
BOND        34
            1     1   2 1
            2     1   3 2
            3     2   4 1
            4     4   5 1
            5     4   6 1
            6     5   7 1
            7     5   8 1
            8     6   9 1
            9     7  10 1
            10    8  11 1
            11   10  12 1
            12   12  13 1
            13   13  14 1
            14   14  15 1
            15   15  16 1
            16   16  17 2
            17   16  18 1
            18   17  19 1
            19   18  20 2
            20   19  21 2
            21   21  22 1
            22    9  10 1
            23   20  21 1
            24    1  23 1
            25   23  24 1
            26   24  25 2
            27   25  26 1
            28   26  27 2
            29   27  28 1
            30   23  28 2
            31   26  29 1
            32   27  30 1
            33   24  31 1
            34   31  32 1

» Japanese version   » Back

DBGET integrated database retrieval system