KEGG   DRUG: D00276Help
Entry
D00276                      Drug                                   

Name
Clarithromycin (JP16/USP/INN);
CAM;
Biaxin (TN)
Product
  Generic
CLARITHROMYCIN (Aidarex Pharmaceuticals LLC), CLARITHROMYCIN (Allied Pharma), CLARITHROMYCIN (American Health Packaging), CLARITHROMYCIN (American Health Packaging), CLARITHROMYCIN (Apotex Corp), CLARITHROMYCIN (Aurobindo Pharma Limited), CLARITHROMYCIN (Bryant Ranch Prepack), CLARITHROMYCIN (Bryant Ranch Prepack), CLARITHROMYCIN (Citron Pharma LLC), CLARITHROMYCIN (Clinical Solutions Wholesale), CLARITHROMYCIN (Dispensing Solutions), CLARITHROMYCIN (KAISER FOUNDATION HOSPITALS), CLARITHROMYCIN (Lake Erie Medical DBA Quality Care Products LLC), CLARITHROMYCIN (Life Line Home Care Services), CLARITHROMYCIN (PD-Rx Pharmaceuticals), CLARITHROMYCIN (PD-Rx Pharmaceuticals), CLARITHROMYCIN (PD-Rx Pharmaceuticals), CLARITHROMYCIN (Physicians Total Care), CLARITHROMYCIN (Physicians Total Care), CLARITHROMYCIN (REMEDYREPACK), CLARITHROMYCIN (REMEDYREPACK), CLARITHROMYCIN (REMEDYREPACK), CLARITHROMYCIN (REMEDYREPACK), CLARITHROMYCIN (REMEDYREPACK), CLARITHROMYCIN (REMEDYREPACK), CLARITHROMYCIN (REMEDYREPACK), CLARITHROMYCIN (REMEDYREPACK), CLARITHROMYCIN (Ranbaxy Pharmaceuticals), CLARITHROMYCIN (Rebel Distributors Corp), CLARITHROMYCIN (Rebel Distributors Corp.), CLARITHROMYCIN (Roxane Laboratories), CLARITHROMYCIN (Sandoz), CLARITHROMYCIN (Sandoz), CLARITHROMYCIN (Teva Pharmaceuticals USA), CLARITHROMYCIN (Teva Pharmaceuticals USA), CLARITHROMYCIN (Watson Laboratories), CLARITHROMYCIN (Watson Pharma), CLARITHROMYCIN (Wockhardt Limited), CLARITHROMYCIN (Wockhardt USA LLC.), CLARITHROMYCIN (bryant ranch prepack)
Formula
C38H69NO13
Exact mass
747.4769
Mol weight
747.9534
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Antibacterial [DS:H00320]
Remark
Same as: 
Therapeutic category: 
ATC code: 
Drug group: 
Comment
Semisynthetic macrolide
Target
23S rRNA of 50S ribosomal subunit, protein synthesis inhibitor [KO:K01980]
  Pathway
ko03010  Ribosome  
 
Metabolism
Enzyme: CYP3A4 [HSA:1576]
Interaction
CYP inhibition: CYP3A [HSA:1576 1577 1551]
Transporter inhibition: ABCB1 [HSA:5243]
Drug interaction
Structure map
Macrolides and ketolides
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 J ANTIINFECTIVES FOR SYSTEMIC USE
  J01 ANTIBACTERIALS FOR SYSTEMIC USE
   J01F MACROLIDES, LINCOSAMIDES AND STREPTOGRAMINS
    J01FA Macrolides
     J01FA09 Clarithromycin
      D00276  Clarithromycin (JP16/USP/INN)
USP drug classification [BR:br08302]
 Antibacterials
  Macrolides
   Clarithromycin
    D00276  Clarithromycin (JP16/USP/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 6  Agents against pathologic organisms and parasites
  61  Antibiotics
   614  Acting mainly on gram-positive bacteria and mycoplasma
    6149  Others
     D00276  Clarithromycin (JP16/USP/INN)
Antiinfectives [BR:br08307]
 Antibacterials
  Protein biosynthesis inhibitor
   23S rRNA of 50S ribosomal subunit inhibitor
    Macrolides
     Clarithromycin
      D00276  Clarithromycin (JP16/USP/INN)
Cytochrome P450 interactions [BR:br08309]
 Substrates
  CYP3A4
   Clarithromycin
    D00276  Clarithromycin (JP16/USP/INN)
 Inhbitors
  CYP3A
   Clarithromycin
    D00276  Clarithromycin (JP16/USP/INN)
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D00276  Clarithromycin
  D00276  Clarithromycin tablets
BRITE hierarchy
Other DBs
CAS: 
81103-11-9
PubChem: 
DrugBank: 
PDB-CCD: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        52
            1   C1y C    24.1709  -17.2043
            2   C1z C    24.1709  -15.8400
            3   C1y C    22.9859  -17.8807
            4   O2a O    25.6666  -18.4812
            5   C1x C    22.9859  -15.1580
            6   C1y C    22.9859  -19.2450
            7   C1a C    21.9450  -16.9275
            8   C1y C    27.4458  -17.6943
            9   C1y C    22.9859  -13.7880
            10  O2a O    23.7258  -20.6034
            11  C1y C    21.8123  -19.9272
            12  C1y C    28.5906  -18.4120
            13  O2x O    27.4113  -16.3303
            14  C5x C    21.8123  -13.1116
            15  C1a C    24.1709  -13.1116
            16  C1y C    24.7548  -21.7190
            17  C7x C    20.6273  -19.2450
            18  C1a C    21.8123  -21.2912
            19  C1y C    29.7920  -17.7775
            20  O1a O    28.5500  -19.7801
            21  C1y C    28.6878  -15.6932
            22  C1y C    20.6273  -13.7880
            23  O5x O    21.8123  -11.7473
            24  C1x C    24.7548  -23.0776
            25  O2x O    25.9398  -21.0369
            26  O7x O    20.6273  -17.8807
            27  O6a O    19.5695  -20.1930
            28  C1x C    29.8379  -16.4196
            29  C1a C    28.7389  -14.3326
            30  C1y C    20.6273  -15.1580
            31  C1a C    19.4481  -13.1116
            32  C1z C    25.9398  -23.7654
            33  C1y C    27.1133  -21.7190
            34  C1y C    19.4481  -17.2043
            35  C1z C    19.4481  -15.8400
            36  O1a O    21.8123  -15.8400
            37  C1y C    27.1133  -23.0776
            38  O2a O    25.9398  -25.0892
            39  C1a C    28.2983  -21.0428
            40  C1b C    18.2688  -17.8807
            41  C1a C    18.1995  -16.4066
            42  O1a O    18.1995  -15.1522
            43  O1a O    28.2983  -23.7654
            44  C1a C    18.3035  -19.0021
            45  C1a C    25.3593  -16.5254
            46  C1a C    27.1615  -25.7951
            47  C1a C    24.7273  -24.4654
            48  O2a O    24.8709  -14.6276
            49  C1a C    26.2709  -14.6276
            50  N1c N    30.9997  -18.5339
            51  C1a C    32.2377  -17.8772
            52  C1a C    31.0187  -19.9487
BOND        54
            1     1   2 1
            2     1   3 1
            3     1   4 1 #Down
            4     2   5 1
            5     3   6 1
            6     3   7 1 #Down
            7     8   4 1 #Down
            8     5   9 1
            9     6  10 1 #Down
            10    6  11 1
            11    8  12 1
            12    8  13 1
            13    9  14 1
            14    9  15 1 #Down
            15   16  10 1 #Down
            16   11  17 1
            17   11  18 1 #Up
            18   12  19 1
            19   12  20 1 #Up
            20   13  21 1
            21   14  22 1
            22   14  23 2
            23   16  24 1
            24   16  25 1
            25   17  26 1
            26   17  27 2
            27   19  28 1
            28   21  29 1 #Down
            29   22  30 1
            30   22  31 1 #Up
            31   24  32 1
            32   25  33 1
            33   26  34 1
            34   30  35 1
            35   30  36 1 #Up
            36   32  37 1
            37   32  38 1 #Down
            38   33  39 1 #Up
            39   34  40 1 #Down
            40   35  41 1 #Down
            41   35  42 1 #Up
            42   37  43 1 #Down
            43   40  44 1
            44   21  28 1
            45   33  37 1
            46   34  35 1
            47    2  45 1 #Down
            48   38  46 1
            49   32  47 1
            50    2  48 1 #Up
            51   48  49 1
            52   19  50 1 #Down
            53   50  51 1
            54   50  52 1

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