KEGG   DRUG: ClofibrateHelp
Entry
D00279                      Drug                                   

Name
Clofibrate (JP17/USP/INN);
Atromid-S (TN)
Formula
C12H15ClO3
Exact mass
242.071
Mol weight
242.6987
Structure
Mol fileKCF fileDB searchJmolKegDraw
Simcomp SIMCOMP
Class
Cardiovascular agent
 DG01946  Hypolipidemic agent
  DG01547  Fibrates
Other
 DG01733  PPAR agonist
  DG01547  Fibrates
Remark
Same as: 
Therapeutic category: 
ATC code: 
Chemical group: 
Activity
Antihyperlipidemic, Triglyceride synthesis inhibitor, Peroxisome proliferator-activated receptor (PPAR) alpha agonist
Comment
Clofibrate derivative
Target
NR1C1 (PPARA) [HSA:5465] [KO:K07294]
  Pathway
PPAR signaling pathway
Adipocytokine signaling pathway
Interaction
Drug interaction
Structure map
Peroxisome proliferator-activated receptor (PPAR) agonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 C CARDIOVASCULAR SYSTEM
  C10 LIPID MODIFYING AGENTS
   C10A LIPID MODIFYING AGENTS, PLAIN
    C10AB Fibrates
     C10AB01 Clofibrate
      D00279  Clofibrate (JP17/USP/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  21  Cardiovascular agents
   218  Hyperlipidemia agents
    2183  Clofibrates
     D00279  Clofibrate (JP17/USP/INN)
Target-based classification of drugs [BR:br08310]
 Nuclear receptors
  Thyroid hormone like receptors
   Peroxisome proliferator-activated receptor (PPAR)
    peroxisome proliferator-activated receptor (PPAR) alpha
     Clofibrate
      D00279  Clofibrate (JP17/USP/INN)
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D00279  Clofibrate
  D00279  Clofibrate capsules
Hypolipidemic agents [br08365.html]
 D00279
BRITE hierarchy
Other DBs
CAS: 
637-07-0
PubChem: 
ChEBI: 
ChEMBL: 
DrugBank: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        16
            1   C8y C    22.6483  -14.4413
            2   O2a O    23.9107  -13.7399
            3   C1d C    25.1030  -14.4413
            4   C7a C    26.2953  -13.7399
            5   O7a O    27.5577  -14.4413
            6   O6a O    26.2953  -12.3373
            7   C1b C    28.7500  -13.7399
            8   C1a C    29.9423  -14.4413
            9   C8x C    21.4560  -13.7399
            10  C8x C    20.1936  -14.4413
            11  C8y C    20.1936  -15.8440
            12  C8x C    21.3858  -16.5453
            13  C8x C    22.6483  -15.8440
            14  X   Cl   19.0013  -16.4752
            15  C1a C    24.1130  -15.4312
            16  C1a C    26.0929  -15.4312
BOND        16
            1     1   2 1
            2     2   3 1
            3     3   4 1
            4     4   5 1
            5     4   6 2
            6     5   7 1
            7     7   8 1
            8     1   9 2
            9     9  10 1
            10   10  11 2
            11   11  12 1
            12   12  13 2
            13    1  13 1
            14   11  14 1
            15    3  15 1
            16    3  16 1

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