KEGG   DRUG: D00280Help
Entry
D00280                      Drug                                   

Name
Clonazepam (JP16/USP/INN);
Klonopin (TN)
Product
  Generic
CLONAZEPAM (A-S Medication Solutions LLC), CLONAZEPAM (Accord Healthcare), CLONAZEPAM (Actavis Elizabeth LLC), CLONAZEPAM (Aidarex Pharmaceuticals LLC), CLONAZEPAM (Aphena Pharma Solutions - Tennessee), CLONAZEPAM (Barr Laboratories), CLONAZEPAM (Bryant Ranch Prepack), CLONAZEPAM (Bryant Ranch Prepack), CLONAZEPAM (Bryant Ranch Prepack), CLONAZEPAM (Caraco Pharmaceutical Laboratories), CLONAZEPAM (Cardinal Health), CLONAZEPAM (Cardinal Health), CLONAZEPAM (Contract Pharmacy Services-PA), CLONAZEPAM (Dispensing Solutions), CLONAZEPAM (Eon Labs), CLONAZEPAM (Golden State Medical Supply), CLONAZEPAM (H.J. Harkins Company), CLONAZEPAM (Lake Erie Medical & Surgical Supply DBA Quality Care Products LLC), CLONAZEPAM (Lake Erie Medical & Surgical Supply DBA Quality Care Products LLC), CLONAZEPAM (Lake Erie Medical & Surgical Supply DBA Quality Care Products LLC), CLONAZEPAM (Lake Erie Medical & Surgical Supply DBA Quality Care Products LLC), CLONAZEPAM (Major Pharmaceuticals), CLONAZEPAM (McKesson Contract Packaging), CLONAZEPAM (McKesson Packaging Services Business Unit of McKesson Corporation), CLONAZEPAM (Mylan Pharmaceuticals), CLONAZEPAM (PD-Rx Pharmaceuticals), CLONAZEPAM (PD-Rx Pharmaceuticals), CLONAZEPAM (PD-Rx Pharmaceuticals), CLONAZEPAM (PD-Rx Pharmaceuticals), CLONAZEPAM (Par Pharmaceutical), CLONAZEPAM (Physicians Total Care), CLONAZEPAM (Physicians Total Care), CLONAZEPAM (Preferred Pharmaceuticals), CLONAZEPAM (Qualitest Pharmaceuticals), CLONAZEPAM (REMEDYREPACK), CLONAZEPAM (REMEDYREPACK), CLONAZEPAM (REMEDYREPACK), CLONAZEPAM (REMEDYREPACK), CLONAZEPAM (Rebel Distributors), CLONAZEPAM (STAT Rx USA LLC), CLONAZEPAM (STAT Rx USA LLC), CLONAZEPAM (STAT Rx USA LLC), CLONAZEPAM (Teva Pharmaceuticals USA), CLONAZEPAM (UDL Laboratories), CLONAZEPAM (Unit Dose Services), CLONAZEPAM (Unit Dose Services), CLONAZEPAM (Unit Dose Services), CLONAZEPAM (REMEDYREPACK)
Formula
C15H10ClN3O3
Exact mass
315.0411
Mol weight
315.7112
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Anticonvulsant
Remark
Therapeutic category: 
ATC code: 
Comment
Benzodiazepines
Target
GABAA-receptor (benzodiazepine binding site) agonist [HSA:2554 2555 2556 2557 2558 2559 2560 2561 2562 2563 2564 2565 2566 2567 2568 55879] [KO:K05175 K05181 K05184 K05185 K05186 K05189 K05192]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04727  GABAergic synapse  
 
Interaction
Drug interaction
Structure map
Anticonvulsants
GABA-A receptor agonists/antagonists
Brite
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  11  Agents affecting central nervous system
   113  Antiepileptics
    1139  Others
     D00280  Clonazepam (JP16/USP/INN)
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N03 ANTIEPILEPTICS
   N03A ANTIEPILEPTICS
    N03AE Benzodiazepine derivatives
     N03AE01 Clonazepam
      D00280  Clonazepam (JP16/USP/INN)
USP drug classification [BR:br08302]
 Anticonvulsants
  Gamma-aminobutyric Acid (GABA) Augmenting Agents
   Clonazepam
    D00280  Clonazepam (JP16/USP/INN)
 Anxiolytics
  Benzodiazepines
   Clonazepam
    D00280  Clonazepam (JP16/USP/INN)
Target-based classification of drugs [BR:br08310]
 Ion channels
  Cys-loop superfamily
   GABA-A
    GABAA-receptor (benzodiazepine binding site) [HSA:2554 2555 2556 2557 2558 2559 2560 2561 2562 2563 2564 2565 2566 2567 2568 55879] [KO:K05175 K05176 K05177 K05178 K05179 K05180 K05181 K05182 K05183 K05184 K05185 K05186 K05187 K05188 K05189 K05192]
     Clonazepam [ATC:N03AE01]
      D00280  Clonazepam (JP16/USP/INN)
BRITE hierarchy
Other DBs
CAS: 
1622-61-3
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        22
            1   C2y C    18.3334  -14.2894
            2   C8y C    17.4913  -13.1798
            3   C8y C    17.8265  -11.8230
            4   N1x N    19.0875  -11.2449
            5   N2x N    19.7392  -14.3146
            6   C5x C    20.3411  -11.8672
            7   C1x C    20.6276  -13.2359
            8   C8x C    16.8194  -10.8546
            9   C8x C    15.4774  -11.2427
            10  C8y C    15.1422  -12.5995
            11  C8x C    16.1493  -13.5676
            12  N2b N    13.7774  -12.9939 #+
            13  C8y C    17.6989  -15.5391
            14  C8x C    16.2973  -15.5391
            15  O5x O    21.4503  -11.0095
            16  C8x C    15.5973  -16.7516
            17  C8x C    16.2973  -17.9640
            18  C8x C    17.6989  -17.9640
            19  C8y C    18.3989  -16.7516
            20  X   Cl   19.8098  -16.7517
            21  O3a O    12.6477  -11.9025 #-
            22  O3a O    13.4361  -14.3745
BOND        24
            1     3   4 1
            2     1   5 2
            3     4   6 1
            4     2   3 1
            5     5   7 1
            6     1   2 1
            7     6   7 1
            8     3   8 2
            9     8   9 1
            10    9  10 2
            11   10  11 1
            12    2  11 2
            13   10  12 1
            14    1  13 1
            15   13  14 1
            16    6  15 2
            17   14  16 2
            18   16  17 1
            19   17  18 2
            20   18  19 1
            21   13  19 2
            22   19  20 1
            23   12  21 1
            24   12  22 2

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