KEGG   DRUG: D00287Help
Entry
D00287                      Drug                                   

Name
Cyclophosphamide hydrate (JP16);
Cyclophosphamide (USP);
Cyclophosphamide tablets (JP16);
Cytoxan (TN);
Neosar (TN)
Product
  Generic
Formula
C7H15Cl2N2O2P. H2O
Exact mass
278.0354
Mol weight
279.1012
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Remark
Same as: 
Therapeutic category: 
ATC code: 
Drug group: 
Comment
Alkylating agent
Prodrug, active substance: Phosphoramide mustard [CPD:C07647]
Target
DNA
Metabolism
Enzyme: CYP2A6 [HSA:1548], CYP2B6 [HSA:1555], CYP2C8 [HSA:1558], CYP2C9 [HSA:1559], CYP3A4 [HSA:1576]
Interaction
Drug interaction
Structure map
Antineoplastics - alkylating agents
Immunosuppressive agents
Antirheumatics - DMARDs and biological agents
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 L ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
  L01 ANTINEOPLASTIC AGENTS
   L01A ALKYLATING AGENTS
    L01AA Nitrogen mustard analogues
     L01AA01 Cyclophosphamide
      D00287  Cyclophosphamide hydrate (JP16); Cyclophosphamide (USP)
USP drug classification [BR:br08302]
 Antineoplastics
  Alkylating Agents
   Cyclophosphamide
    D00287  Cyclophosphamide hydrate (JP16); Cyclophosphamide (USP)
Therapeutic category of drugs in Japan [BR:br08301]
 4  Agents affecting cellular function
  42  Antineoplastics
   421  Alkylating agents
    4211  Chlorethylamines
     D00287  Cyclophosphamide hydrate (JP16); Cyclophosphamide (USP); Cyclophosphamide tablets (JP16)
Antineoplastics [BR:br08308]
 Alkylating agents
  Nitrogen mustard analogs
   Cyclophosphamide
    D00287  Cyclophosphamide hydrate (JP16); Cyclophosphamide (USP)
Cytochrome P450 interactions [BR:br08309]
 Substrates
  CYP2B6
   Cyclophosphamide
    D00287  Cyclophosphamide hydrate (JP16); Cyclophosphamide (USP)
  CYP2C8
   Cyclophosphamide
    D00287  Cyclophosphamide hydrate (JP16); Cyclophosphamide (USP)
  CYP2C9
   Cyclophosphamide
    D00287  Cyclophosphamide hydrate (JP16); Cyclophosphamide (USP)
  CYP3A4
   Cyclophosphamide
    D00287  Cyclophosphamide hydrate (JP16); Cyclophosphamide (USP)
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D00287  Cyclophosphamide hydrate
  D00287  Cyclophosphamide tablets
BRITE hierarchy
Other DBs
CAS: 
6055-19-2
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        15
            1   P1a P    22.9658  -14.9801
            2   N1c N    22.9715  -13.5156
            3   N1x N    24.0976  -15.6395
            4   O2x O    21.8279  -15.6395
            5   O3b O    21.6997  -14.2450
            6   C1b C    21.6646  -12.8388
            7   C1b C    24.2027  -12.7220
            8   C1x C    24.0976  -16.9523
            9   C1x C    21.8279  -16.9523
            10  C1b C    20.4335  -13.6264
            11  C1b C    25.5096  -13.3990
            12  C1x C    22.9658  -17.5999
            13  X   Cl   19.1265  -12.9613
            14  X   Cl   26.7467  -12.6054
            15  O0  O    27.7975  -15.3471
BOND        14
            1     1   2 1
            2     1   3 1
            3     1   4 1
            4     1   5 2
            5     2   6 1
            6     2   7 1
            7     3   8 1
            8     4   9 1
            9     6  10 1
            10    7  11 1
            11    8  12 1
            12   10  13 1
            13   11  14 1
            14    9  12 1

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