KEGG   DRUG: D00290Help
Entry
D00290                      Drug                                   

Name
Demethylchlortetracycline hydrochloride (JP16);
Demeclocycline hydrochloride (USP);
DMCTC;
Declomycin (TN)
Product
  Generic
Formula
C21H21ClN2O8. HCl
Exact mass
500.0753
Mol weight
501.314
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Antibacterial [DS:H00312 H00319 H00322 H00324 H00328 H00336]
Remark
Therapeutic category: 
ATC code: 
Drug group: 
Target
16S rRNA of 30S ribosomal subunit, protein synthesis inhibitor [KO:K01977]
  Pathway
ko03010  Ribosome  
 
Interaction
Drug interaction
Structure map
Tetracyclines
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 D DERMATOLOGICALS
  D06 ANTIBIOTICS AND CHEMOTHERAPEUTICS FOR DERMATOLOGICAL USE
   D06A ANTIBIOTICS FOR TOPICAL USE
    D06AA Tetracycline and derivatives
     D06AA01 Demeclocycline
      D00290  Demethylchlortetracycline hydrochloride (JP16); Demeclocycline hydrochloride (USP)
 J ANTIINFECTIVES FOR SYSTEMIC USE
  J01 ANTIBACTERIALS FOR SYSTEMIC USE
   J01A TETRACYCLINES
    J01AA Tetracyclines
     J01AA01 Demeclocycline
      D00290  Demethylchlortetracycline hydrochloride (JP16); Demeclocycline hydrochloride (USP)
USP drug classification [BR:br08302]
 Antibacterials
  Tetracyclines
   Demeclocycline
    D00290  Demethylchlortetracycline hydrochloride (JP16); Demeclocycline hydrochloride (USP)
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  26  Epidermides
   263  Suppurative dermatosis agents
    2634  Antibiotics for external use
     D00290  Demethylchlortetracycline hydrochloride (JP16); Demeclocycline hydrochloride (USP)
 6  Agents against pathologic organisms and parasites
  61  Antibiotics
   615  Acting mainly on gram-positive bacteria, gram-negative bacteria, rickettsia and chlamydia
    6152  Tetracycline antibiotics
     D00290  Demethylchlortetracycline hydrochloride (JP16); Demeclocycline hydrochloride (USP)
Classification of Japanese OTC drugs [BR:br08313]
 Agents for integumentary system
  56 Purulent skin remedies
   D00290  Demethylchlortetracycline hydrochloride (JP16); Demeclocycline hydrochloride (USP)
  -- Eczematous and dermatitis remedies
   D00290  Demethylchlortetracycline hydrochloride (JP16); Demeclocycline hydrochloride (USP)
Risk category of Japanese OTC drugs [BR:br08312]
 Second-class OTC drugs
  Inorganic and organic chemicals
   Demethylchlortetracycline
    D00290  Demethylchlortetracycline hydrochloride (JP16); Demeclocycline hydrochloride (USP)
Antiinfectives [BR:br08307]
 Antibacterials
  Protein biosynthesis inhibitor
   16S rRNA of 30S ribosomal subunit inhibitor
    Tetracyclines
     Demeclocycline
      D00290  Demethylchlortetracycline hydrochloride (JP16); Demeclocycline hydrochloride (USP)
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D00290  Demethylchlortetracycline hydrochloride
BRITE hierarchy
Other DBs
CAS: 
64-73-3
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        33
            1   C1y C    27.8011  -14.6050
            2   C1z C    27.7894  -15.9888
            3   C1y C    29.0038  -13.9160
            4   C1x C    26.5925  -13.9044
            5   C2y C    26.5925  -16.6895
            6   C5x C    28.9863  -16.6895
            7   O1a O    27.7894  -17.3842
            8   C2y C    30.2007  -14.6167
            9   N1c N    29.0097  -12.5149
            10  C1y C    25.3840  -14.6050
            11  C2y C    25.3840  -16.0005
            12  O1a O    26.5984  -18.0964
            13  C2y C    30.1949  -16.0063
            14  O5x O    28.9806  -18.0905
            15  O1a O    31.4151  -13.9220
            16  C1a C    30.2300  -11.8202
            17  C1a C    27.8011  -11.8085
            18  C1y C    24.1697  -13.9044
            19  C5x C    24.1814  -16.7069
            20  C5a C    31.3975  -16.7069
            21  C8y C    22.9611  -14.6167
            22  O1a O    24.1697  -12.5032
            23  C8y C    22.9669  -16.0122
            24  O5x O    24.1231  -18.1081
            25  N1a N    32.6177  -16.0180
            26  O5a O    31.4617  -18.1138
            27  C8y C    21.7467  -13.9160
            28  C8y C    21.7643  -16.7186
            29  C8x C    20.5323  -14.6284
            30  X   Cl   21.7409  -12.5091
            31  C8x C    20.5440  -16.0296
            32  O1a O    21.7760  -18.1255
            33  X   Cl   35.9659  -14.7457
BOND        35
            1     1   2 1
            2     1   3 1
            3     1   4 1
            4     2   5 1
            5     2   6 1
            6     2   7 1 #Down
            7     3   8 1
            8     3   9 1 #Down
            9     4  10 1
            10    5  11 2
            11    5  12 1
            12    6  13 1
            13    6  14 2
            14    8  15 1
            15    9  16 1
            16    9  17 1
            17   10  18 1
            18   11  19 1
            19   13  20 1
            20   18  21 1
            21   18  22 1 #Up
            22   19  23 1
            23   19  24 2
            24   20  25 1
            25   20  26 2
            26   21  27 1
            27   23  28 1
            28   27  29 2
            29   27  30 1
            30   28  31 2
            31   28  32 1
            32    8  13 2
            33   10  11 1
            34   21  23 2
            35   29  31 1

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