KEGG   DRUG: D00292Help
Entry
D00292                      Drug                                   
Name
Dexamethasone (JP16/USP/INN);
Decadron (TN);
Maxidex (TN)
Product
  Generic
DEXAMETHASONE (Bryant Ranch Prepack), DEXAMETHASONE (Bryant Ranch Prepack), DEXAMETHASONE (Bryant Ranch Prepack), DEXAMETHASONE (Cardinal Health), DEXAMETHASONE (Cardinal Health), DEXAMETHASONE (Dispensing Solutions), DEXAMETHASONE (ECR Pharmaceuticals), DEXAMETHASONE (ECR Pharmaceuticals), DEXAMETHASONE (ECR Pharmaceuticals), DEXAMETHASONE (ECR Pharmaceuticals), DEXAMETHASONE (H.J. Harkins Company), DEXAMETHASONE (Lake Erie Medical & Surgical Supply DBA Quality Care Products LLC), ZEMA PAK (Macoven Pharmaceuticals LLC), DEXAMETHASONE (Morton Grove Pharmaceuticals), DEXAMETHASONE (PD-Rx Pharmaceuticals), DEXAMETHASONE (PD-Rx Pharmaceuticals), DEXAMETHASONE (PD-Rx Pharmaceuticals), DEXAMETHASONE (Par Pharmaceutical), DEXAMETHASONE (Physicians Total Care), DEXAMETHASONE (Physicians Total Care), DEXAMETHASONE (Preferred Pharmaceuticals), DEXAMETHASONE (Qualitest Pharmaceuticals), DEXAMETHASONE (Rebel Distributors Corp), DEXAMETHASONE (Rebel Distributors Corp), DEXAMETHASONE (Rising Pharmaceuticals), DEXAMETHASONE (STAT Rx USA LLC), DEXAMETHASONE (STI Pharma LLC), DEXAMETHASONE (STI Pharma LLC), BAYCADRON (Wockhardt USA), DEXAMETHASONE INTENSOL (Roxane Laboratories)
Formula
C22H29FO5
Exact mass
392.1999
Mol weight
392.4611
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Glucocorticoid
Remark
Target
glucocorticoid receptor agonist [HSA:2908] [KO:K05771]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction  
 
Metabolism
Enzyme: CYP3A4 [HSA:1576]
Interaction
CYP induction: CYP2D6 [HSA:1565]
Drug interaction
Structure map
Antineoplastics - hormones
Immunosuppressive agents
Glucocorticoid and meneralocorticoid receptor agonists/antagonists
Brite
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  13  Agents affecting sensory organs
   131  Ophthalmic agents
    1315  Ophthalmic cortisones
     D00292  Dexamethasone (JP16/USP/INN)
 2  Agents affecting individual organs
  23  Digestive organ agents
   239  Miscellaneous
    2399  Others
     D00292  Dexamethasone (JP16/USP/INN)
  24  Hormones
   245  Adrenal hormone preparations
    2454  Fluorinated adrenocorticotropic hormones
     D00292  Dexamethasone (JP16/USP/INN)
  26  Epidermides
   264  Analgesics, anti-itchings, astringents, anti-inflammatory agents
    2646  Adrenocorticotropic hormones
     D00292  Dexamethasone (JP16/USP/INN)
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 A ALIMENTARY TRACT AND METABOLISM
  A01 STOMATOLOGICAL PREPARATIONS
   A01A STOMATOLOGICAL PREPARATIONS
    A01AC Corticosteroids for local oral treatment
     A01AC02 Dexamethasone
      D00292  Dexamethasone (JP16/USP/INN)
 C CARDIOVASCULAR SYSTEM
  C05 VASOPROTECTIVES
   C05A AGENTS FOR TREATMENT OF HEMORRHOIDS AND ANAL FISSURES FOR TOPICAL USE
    C05AA Corticosteroids
     C05AA09 Dexamethasone
      D00292  Dexamethasone (JP16/USP/INN)
 D DERMATOLOGICALS
  D07 CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS
   D07A CORTICOSTEROIDS, PLAIN
    D07AB Corticosteroids, moderately potent (group II)
     D07AB19 Dexamethasone
      D00292  Dexamethasone (JP16/USP/INN)
   D07X CORTICOSTEROIDS, OTHER COMBINATIONS
    D07XB Corticosteroids, moderately potent, other combinations
     D07XB05 Dexamethasone
      D00292  Dexamethasone (JP16/USP/INN)
  D10 ANTI-ACNE PREPARATIONS
   D10A ANTI-ACNE PREPARATIONS FOR TOPICAL USE
    D10AA Corticosteroids, combinations for treatment of acne
     D10AA03 Dexamethasone
      D00292  Dexamethasone (JP16/USP/INN)
 H SYSTEMIC HORMONAL PREPARATIONS, EXCL. SEX HORMONES AND INSULINS
  H02 CORTICOSTEROIDS FOR SYSTEMIC USE
   H02A CORTICOSTEROIDS FOR SYSTEMIC USE, PLAIN
    H02AB Glucocorticoids
     H02AB02 Dexamethasone
      D00292  Dexamethasone (JP16/USP/INN)
 R RESPIRATORY SYSTEM
  R01 NASAL PREPARATIONS
   R01A DECONGESTANTS AND OTHER NASAL PREPARATIONS FOR TOPICAL USE
    R01AD Corticosteroids
     R01AD03 Dexamethasone
      D00292  Dexamethasone (JP16/USP/INN)
 S SENSORY ORGANS
  S01 OPHTHALMOLOGICALS
   S01B ANTIINFLAMMATORY AGENTS
    S01BA Corticosteroids, plain
     S01BA01 Dexamethasone
      D00292  Dexamethasone (JP16/USP/INN)
   S01C ANTIINFLAMMATORY AGENTS AND ANTIINFECTIVES IN COMBINATION
    S01CB Corticosteroids/antiinfectives/mydriatics in combination
     S01CB01 Dexamethasone
      D00292  Dexamethasone (JP16/USP/INN)
  S02 OTOLOGICALS
   S02B CORTICOSTEROIDS
    S02BA Corticosteroids
     S02BA06 Dexamethasone
      D00292  Dexamethasone (JP16/USP/INN)
  S03 OPHTHALMOLOGICAL AND OTOLOGICAL PREPARATIONS
   S03B CORTICOSTEROIDS
    S03BA Corticosteroids
     S03BA01 Dexamethasone
      D00292  Dexamethasone (JP16/USP/INN)
USP drug classification [BR:br08302]
 Hormonal Agents
  Hormonal Agents, Stimulant / Replacement / Modifying (Adrenal)
   Glucocorticoid / Mineralocorticoid
    Glucocorticoids, Systemic
     Dexamethasone
      D00292  Dexamethasone (JP16/USP/INN)
    Glucocorticoids, Topical - Low Potency
     Dexamethasone
      D00292  Dexamethasone (JP16/USP/INN)
 Inflammatory Bowel Disease Agents
  Glucocorticoids
   Dexamethasone
    D00292  Dexamethasone (JP16/USP/INN)
 Ophthalmic Agents
  Ophthalmic Anti-inflammatories
   Glucocorticoids, Ophthalmic
    Dexamethasone
     D00292  Dexamethasone (JP16/USP/INN)
Target-based classification of drugs [BR:br08310]
 Nuclear receptors
  Estrogen like receptors
   3-Ketosteroid receptor
    glucocorticoid receptor [HSA:2908] [KO:K05771]
     Dexamethasone [ATC:A01AC02 C05AA09 D07AB19 D07XB05 D10AA03 H02AB02 R01AD03 S01BA01 S01CB01 S02BA06 S03BA01]
      D00292  Dexamethasone (JP16/USP/INN)
Antineoplastics [BR:br08308]
 Hormones and hormone antagonist
  Corticosteroid
   Dexamethasone [ATC:A01AC02]
    D00292  Dexamethasone (JP16/USP/INN)
BRITE hierarchy
Other DBs
CAS: 
50-02-2
PubChem: 
DrugBank: 
PDB-CCD: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        28
            1   C2x C     6.5292  -16.7310
            2   C5x C     6.5292  -18.0917
            3   C2x C     7.7075  -18.7720
            4   C2y C     8.8859  -18.0917
            5   C1z C     8.8859  -16.7310
            6   C2x C     7.7075  -16.0507
            7   C1x C    10.0643  -18.7720
            8   C1x C    11.2426  -18.0917
            9   C1y C    11.2426  -16.7310
            10  C1z C    10.0643  -16.0507
            11  C1y C    12.4210  -16.0507
            12  C1z C    12.4210  -14.6900
            13  C1x C    11.2426  -14.0097
            14  C1y C    10.0643  -14.6900
            15  C1x C    14.7777  -16.0507
            16  C1y C    14.7777  -14.6900
            17  C1z C    13.5994  -14.0097
            18  C1a C     8.8859  -15.3703
            19  O1a O     8.8879  -14.0109
            20  C1a C    12.4210  -13.3294
            21  C1a C    15.9436  -14.0168
            22  C5a C    13.5994  -12.3089
            23  X   F    10.0643  -17.4113
            24  O1a O    14.7777  -13.1194
            25  O5x O     5.3509  -18.7720
            26  O5a O    14.7817  -11.6263
            27  C1b C    12.4249  -11.6308
            28  O1a O    11.2650  -12.3007
BOND        31
            1     1   2 1
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 1
            6     1   6 2
            7     4   7 1
            8     7   8 1
            9     8   9 1
            10    9  10 1
            11    5  10 1
            12    9  11 1
            13   11  12 1
            14   12  13 1
            15   13  14 1
            16   10  14 1
            17   11  15 1
            18   15  16 1
            19   16  17 1
            20   12  17 1
            21    5  18 1 #Up
            22   14  19 1 #Up
            23   12  20 1 #Up
            24   16  21 1 #Down
            25   17  22 1 #Up
            26   10  23 1 #Down
            27   17  24 1 #Down
            28    2  25 2
            29   22  26 2
            30   22  27 1
            31   27  28 1

» Japanese version   » Back
DBGET integrated database retrieval system