KEGG   DRUG: D00298Help
Entry
D00298                      Drug                                   

Name
Digoxin (JP16/USP);
Lanoxicaps (TN);
Lanoxin (TN)
Product
  Generic
DIGOXIN (A-S Medication Solutions LLC), DIGOX (Aidarex Pharmaceuticals LLC), DIGOXIN (American Health Packaging), DIGOXIN (Bryant Ranch Prepack), DIGOXIN (Bryant Ranch Prepack), DIGOXIN (Caraco Pharmaceutical Laboratories), DIGOXIN (Cardinal Health), DIGOXIN (Cardinal Health), DIGOXIN (Cardinal Health), DIGOXIN (Cardinal Health), DIGOX (Carilion Materials Management), DIGOX (Carilion Materials Management), DIGOXIN (DEPT HEALTH CENTRAL PHARMACY), DIGOXIN (General Injecatables & Vaccines), DIGOXIN (Global Pharmaceuticals), DIGOXIN (Golden State Medical Supply), DIGOXIN (Jerome Stevens Pharmaceuticals), DIGOX (Lake Erie Medical DBA Quality Care Products LLC), DIGOX (Lannett Company), DIGOXIN (Major Pharmaceuticals), DIGOX (McKesson Contract Packaging), DIGOXIN (McKesson Contract Packaging), DIGOXIN (NCS HealthCare of KY), DIGOXIN (NCS HealthCare of KY), DIGOXIN (NCS HealthCare of KY), DIGOXIN (Northwind Pharmaceuticals), DIGOXIN (Northwind Pharmaceuticals), DIGOXIN (PD-Rx Pharmaceuticals), DIGOX (PD-Rx Pharmaceuticals), DIGOXIN (Par Pharmaceutical), DIGOXIN (Par Pharmaceutical), DIGOXIN (Physicians Total Care), DIGOX (REMEDYREPACK), DIGOXIN (REMEDYREPACK), DIGOX (REMEDYREPACK), DIGOXIN (REMEDYREPACK), DIGOXIN (Rebel Distributors Corp), DIGOXIN (Sandoz), DIGOX (St Marys Medical Park Pharmacy), DIGOX (St Marys Medical Park Pharmacy), DIGOXIN (State of Florida DOH Central Pharmacy), DIGOXIN (State of Florida DOH Central Pharmacy), DIGOXIN (State of Florida DOH Central Pharmacy), DIGOX (Unit Dose Services), DIGOX (Unit Dose Services), DIGOXIN (West-Ward Pharmaceutical Corp), DIGOXIN (West-Ward Pharmaceutical Corp.)
Formula
C41H64O14
Exact mass
780.4296
Mol weight
780.9385
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Cardiotonic
Remark
Same as: 
Therapeutic category: 
ATC code: 
Target
Na+,K+-ATPase inhibitor [HSA:476 477 478 480 23439 481 482 483] [KO:K01539 K01540]
  Pathway
hsa04260  Cardiac muscle contraction  
 
Metabolism
Transporter: SLCO1B3 [HSA:28234], SLCO1A2 [HSA:6579], ABCB1 [HSA:5243], ABCB4 [HSA:5244]
Interaction
Drug interaction
Structure map
Ion transporter inhibitors
Other map
Bile secretion
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 C CARDIOVASCULAR SYSTEM
  C01 CARDIAC THERAPY
   C01A CARDIAC GLYCOSIDES
    C01AA Digitalis glycosides
     C01AA05 Digoxin
      D00298  Digoxin (JP16/USP)
USP drug classification [BR:br08302]
 Cardiovascular Agents
  Cardiovascular Agents, Other
   Digoxin
    D00298  Digoxin (JP16/USP)
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  21  Cardiovascular agents
   211  Cardiotonics
    2113  Digitalis
     D00298  Digoxin (JP16/USP)
Target-based classification of drugs [BR:br08310]
 Enzymes
  Hydrolases
   sodium/potassium-transporting ATPase
    Digoxin
     D00298  Digoxin (JP16/USP)
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D00298  Digoxin
  D00298  Digoxin tablets
  D00298  Digoxin injection
Phytochemicals used as drugs [BR:br08306]
 Terpenoids
  Triterpenoids (C30) and related compounds
   D00298  Digoxin (JP15/USP)
BRITE hierarchy
Other DBs
CAS: 
20830-75-5
PubChem: 
DrugBank: 
PDB-CCD: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        55
            1   O2a O    19.0116  -23.7433
            2   C1y C    20.2043  -22.9712
            3   C1x C    21.4154  -23.6705
            4   C1y C    22.6265  -22.9712
            5   C1z C    22.6265  -21.5727
            6   C1x C    21.4154  -20.8735
            7   C1x C    20.2043  -21.5727
            8   C1x C    23.8377  -23.6705
            9   C1x C    25.0488  -22.9712
            10  C1y C    25.0488  -21.5727
            11  C1y C    23.8377  -20.8735
            12  C1z C    26.2599  -20.8735
            13  C1z C    26.2599  -19.4750
            14  C1y C    25.0488  -18.7757
            15  C1x C    23.8377  -19.4750
            16  C1x C    27.5900  -21.3056
            17  C1x C    28.4120  -20.1742
            18  C1y C    27.5900  -19.0429
            19  C2y C    28.0287  -17.6913
            20  C2x C    29.4379  -17.7196
            21  C7x C    29.9019  -16.3923
            22  O7x O    28.7831  -15.5409
            23  C1x C    27.6277  -16.3417
            24  O6a O    31.2254  -15.9949
            25  C1a C    26.2599  -18.0765
            26  O1a O    26.2599  -22.2720
            27  C1a C    22.6265  -20.1742
            28  C1y C    17.7607  -23.1038
            29  O2x O    17.7607  -21.7053
            30  C1y C    16.5495  -21.0061
            31  C1y C    15.3384  -21.7053
            32  C1y C    15.3384  -23.1038
            33  C1x C    16.5495  -23.8031
            34  O2a O    14.1273  -21.0061
            35  C1y C    12.9161  -21.7053
            36  O2x O    12.9161  -23.1038
            37  O1a O    14.1273  -23.8031
            38  C1x C    11.7050  -21.0061
            39  C1y C    10.4939  -21.7053
            40  C1y C    10.4939  -23.1038
            41  C1y C    11.7050  -23.8031
            42  O1a O     9.2827  -21.0061
            43  O2x O     8.0716  -21.7053
            44  C1y C     8.0716  -23.1038
            45  O2a O     9.2827  -23.8031
            46  C1y C     6.8605  -21.0061
            47  C1y C     5.6493  -21.7053
            48  C1y C     5.6493  -23.1038
            49  C1x C     6.8605  -23.8031
            50  O1a O     4.4382  -21.0061
            51  O1a O     4.4382  -23.8031
            52  C1a C    16.5492  -19.5884
            53  C1a C    11.7046  -25.1819
            54  C1a C     6.8606  -19.5882
            55  O1a O    25.0488  -17.3757
BOND        62
            1     2   1 1 #Up
            2     2   3 1
            3     3   4 1
            4     4   5 1
            5     5   6 1
            6     6   7 1
            7     2   7 1
            8     4   8 1
            9     8   9 1
            10    9  10 1
            11   10  11 1
            12    5  11 1
            13   10  12 1
            14   12  13 1
            15   13  14 1
            16   14  15 1
            17   11  15 1
            18   12  16 1
            19   16  17 1
            20   17  18 1
            21   13  18 1
            22   18  19 1 #Up
            23   19  20 2
            24   20  21 1
            25   21  22 1
            26   22  23 1
            27   19  23 1
            28   21  24 2
            29   13  25 1 #Up
            30   12  26 1 #Up
            31    5  27 1 #Up
            32   28   1 1 #Up
            33   28  29 1
            34   29  30 1
            35   30  31 1
            36   31  32 1
            37   32  33 1
            38   28  33 1
            39   31  34 1 #Down
            40   35  34 1 #Down
            41   35  36 1
            42   32  37 1 #Down
            43   35  38 1
            44   38  39 1
            45   39  40 1
            46   40  41 1
            47   36  41 1
            48   39  42 1 #Up
            49   43  44 1
            50   44  45 1 #Up
            51   40  45 1 #Up
            52   43  46 1
            53   46  47 1
            54   47  48 1
            55   48  49 1
            56   44  49 1
            57   47  50 1 #Down
            58   48  51 1 #Down
            59   30  52 1 #Up
            60   41  53 1 #Down
            61   46  54 1 #Up
            62   14  55 1 #Up

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