KEGG   DRUG: D00300Help
Entry
D00300                      Drug                                   

Name
Diphenhydramine (JP16/INN);
Restamin (TN)
Formula
C17H21NO
Exact mass
255.1623
Mol weight
255.3547
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Antihistaminic
Remark
Same as: 
Therapeutic category: 
ATC code: 
Drug group: 
Target
H1-receptor antagonist [HSA:3269] [KO:K04149]
  Pathway
hsa04020  Calcium signaling pathway
hsa04080  Neuroactive ligand-receptor interaction  
 
Metabolism
Enzyme: CYP2D6 [HSA:1565]
Interaction
CYP inhibition: CYP2D6 [HSA:1565]
Transporter inhibition: SLC22A2 [HSA:6582]
Drug interaction
Structure map
Antipsychotics
Hypnotics
Histamine H1 receptor antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 D DERMATOLOGICALS
  D04 ANTIPRURITICS, INCL. ANTIHISTAMINES, ANESTHETICS, ETC.
   D04A ANTIPRURITICS, INCL. ANTIHISTAMINES, ANESTHETICS, ETC.
    D04AA Antihistamines for topical use
     D04AA32 Diphenhydramine
      D00300  Diphenhydramine (JP16/INN)
 R RESPIRATORY SYSTEM
  R06 ANTIHISTAMINES FOR SYSTEMIC USE
   R06A ANTIHISTAMINES FOR SYSTEMIC USE
    R06AA Aminoalkyl ethers
     R06AA02 Diphenhydramine
      D00300  Diphenhydramine (JP16/INN)
USP drug classification [BR:br08302]
 Antiemetics
  Antiemetics, Other
   Diphenhydramine
    D00300  Diphenhydramine (JP16/INN)
 Antiparkinson Agents
  Anticholinergics
   Diphenhydramine
    D00300  Diphenhydramine (JP16/INN)
 Respiratory Tract/Pulmonary Agents
  Antihistamines
   Diphenhydramine
    D00300  Diphenhydramine (JP16/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  26  Epidermides
   264  Analgesics, anti-itchings, astringents, anti-inflammatory agents
    2642  Antihistamines for external use
     D00300  Diphenhydramine (JP16/INN)
Classification of Japanese OTC drugs [BR:br08313]
 Agents for integumentary system
  57 Analgesic, antipruritic, astringent, and anti-inflammatory remedies (incl. gel patches)
   D00300  Diphenhydramine (JP16/INN)
  -- Eczematous and dermatitis remedies
   D00300  Diphenhydramine (JP16/INN)
  -- Antipruritic and insect sting remedies
   D00300  Diphenhydramine (JP16/INN)
Risk category of Japanese OTC drugs [BR:br08312]
 Specified Category 2
  Inorganic and organic chemicals
   Diphenhydramine
    D00300  Diphenhydramine (JP16/INN)
 Category 2
  Inorganic and organic chemicals
   Diphenhydramine
    D00300  Diphenhydramine (JP16/INN)
 Category 3
  Inorganic and organic chemicals
   Diphenhydramine
    D00300  Diphenhydramine (JP16/INN)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Histamine
    H1-receptor
     Diphenhydramine
      D00300  Diphenhydramine (JP16/INN)
Cytochrome P450 interactions [BR:br08309]
 Substrates
  CYP2D6
   Diphenhydramine
    D00300  Diphenhydramine (JP16/INN)
 Inhbitors
  CYP2D6
   Diphenhydramine
    D00300  Diphenhydramine (JP16/INN)
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D00300  Diphenhydramine
BRITE hierarchy
Other DBs
CAS: 
58-73-1
PubChem: 
DrugBank: 
PDB-CCD: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        19
            1   C1c C    30.1190  -16.7924
            2   C8y C    28.9084  -17.4966
            3   C8y C    31.3355  -17.4966
            4   O2a O    30.1249  -15.3955
            5   C8x C    28.9084  -18.8994
            6   C8x C    27.6977  -16.7924
            7   C8x C    31.3298  -18.8994
            8   C8x C    32.5403  -16.7924
            9   C1b C    31.3355  -14.6912
            10  C8x C    27.6977  -19.5919
            11  C8x C    26.4812  -17.4966
            12  C8x C    32.5403  -19.5919
            13  C8x C    33.7568  -17.4966
            14  C8x C    26.4812  -18.8994
            15  C8x C    33.7509  -18.8994
            16  C1b C    32.5712  -15.4021
            17  N1c N    33.7675  -14.7088
            18  C1a C    34.9566  -15.3928
            19  C1a C    33.7653  -13.3002
BOND        20
            1     5  10 2
            2     6  11 1
            3     7  12 1
            4     8  13 2
            5    10  14 1
            6    12  15 2
            7    11  14 2
            8    13  15 1
            9     1   2 1
            10    1   3 1
            11    1   4 1
            12    2   5 1
            13    2   6 2
            14    3   7 2
            15    3   8 1
            16    4   9 1
            17    9  16 1
            18   16  17 1
            19   17  18 1
            20   17  19 1

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