KEGG   DRUG: D00303Help
Entry
D00303                      Drug                                   

Name
Disopyramide (JP16/USAN/INN);
Rythmodan P (TN)
Formula
C21H29N3O
Exact mass
339.2311
Mol weight
339.4745
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Cardiac depressant [anti-arrhythmic] [DS:H00292]
Remark
Same as: 
Therapeutic category: 
ATC code: 
Comment
Class I antiarrhythmic agent (Ia)
Target
voltage-gated sodium channel (SCN1A) blocker [HSA:6323] [KO:K04833];
voltage-gated sodium channel (SCN2A) blocker [HSA:6326] [KO:K04834];
voltage-gated sodium channel (SCN3A) blocker [HSA:6328] [KO:K04836];
voltage-gated sodium channel (SCN4A) blocker [HSA:6329] [KO:K04837];
voltage-gated sodium channel (SCN5A) blocker [HSA:6331] [KO:K04838];
voltage-gated sodium channel (SCN8A) blocker [HSA:6334] [KO:K04840];
voltage-gated sodium channel (SCN9A) blocker [HSA:6335] [KO:K04841]
  Pathway
hsa04728  Dopaminergic synapse  
 
Metabolism
Enzyme: CYP3A4 [HSA:1576]
Transporter: SLC22A3 [HSA:6581]
Interaction
Transporter inhibition: SLC22A1 [HSA:6580]
Drug interaction
Structure map
Antiarrhythmic drugs
Sodium channel blocking drugs
Brite
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  21  Cardiovascular agents
   212  Antiarrhythmic agents
    2129  Others
     D00303  Disopyramide (JP16/USAN/INN)
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 C CARDIOVASCULAR SYSTEM
  C01 CARDIAC THERAPY
   C01B ANTIARRHYTHMICS, CLASS I AND III
    C01BA Antiarrhythmics, class Ia
     C01BA03 Disopyramide
      D00303  Disopyramide (JP16/USAN/INN)
USP drug classification [BR:br08302]
 Cardiovascular Agents
  Antiarrhythmics
   Disopyramide
    D00303  Disopyramide (JP16/USAN/INN)
Target-based classification of drugs [BR:br08310]
 Ion channels
  Voltage-gated cation channels
   Na+ channel, SCN alpha, NaV1.x
    voltage-gated sodium channel (SCN1A) [HSA:6323] [KO:K04833]
     Disopyramide [ATC:C01BA03]
      D00303  Disopyramide (JP16/USAN/INN)
    voltage-gated sodium channel (SCN2A) [HSA:6326] [KO:K04834]
     Disopyramide [ATC:C01BA03]
      D00303  Disopyramide (JP16/USAN/INN)
    voltage-gated sodium channel (SCN3A) [HSA:6328] [KO:K04836]
     Disopyramide [ATC:C01BA03]
      D00303  Disopyramide (JP16/USAN/INN)
    voltage-gated sodium channel (SCN4A) [HSA:6329] [KO:K04837]
     Disopyramide [ATC:C01BA03]
      D00303  Disopyramide (JP16/USAN/INN)
    voltage-gated sodium channel (SCN5A) [HSA:6331] [KO:K04838]
     Disopyramide [ATC:C01BA03]
      D00303  Disopyramide (JP16/USAN/INN)
    voltage-gated sodium channel (SCN8A) [HSA:6334] [KO:K04840]
     Disopyramide [ATC:C01BA03]
      D00303  Disopyramide (JP16/USAN/INN)
    voltage-gated sodium channel (SCN9A) [HSA:6335] [KO:K04841]
     Disopyramide [ATC:C01BA03]
      D00303  Disopyramide (JP16/USAN/INN)
BRITE hierarchy
Other DBs
CAS: 
3737-09-5
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        25
            1   C8x C    22.8200  -18.9000
            2   C8x C    22.8200  -20.3000
            3   C8x C    24.0324  -21.0000
            4   N5x N    25.2449  -20.3000
            5   C8y C    25.2449  -18.9000
            6   C8x C    24.0324  -18.2000
            7   C8x C    27.6697  -20.3000
            8   C8y C    27.6697  -18.9000
            9   C1d C    26.4573  -18.2000
            10  C8x C    28.8822  -21.0000
            11  C8x C    30.0946  -20.3000
            12  C8x C    30.0946  -18.9000
            13  C8x C    28.8822  -18.2000
            14  C1b C    26.4573  -16.8000
            15  C1b C    27.6718  -16.0988
            16  C5a C    24.4049  -17.0800
            17  N1a N    24.4049  -15.6800
            18  O5a O    23.2168  -17.7786
            19  N1c N    27.6718  -14.5602
            20  C1c C    28.8679  -13.8695
            21  C1c C    26.4430  -13.8506
            22  C1a C    25.2393  -14.5455
            23  C1a C    26.4432  -12.4601
            24  C1a C    30.0553  -14.5551
            25  C1a C    28.8680  -12.4603
BOND        26
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     7   8 1
            8     8   9 1
            9     5   9 1
            10    7  10 2
            11   10  11 1
            12   11  12 2
            13   12  13 1
            14    8  13 2
            15    9  14 1
            16   14  15 1
            17    9  16 1
            18   16  17 1
            19   16  18 2
            20   15  19 1
            21   19  20 1
            22   19  21 1
            23   21  22 1
            24   21  23 1
            25   20  24 1
            26   20  25 1

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