KEGG   DRUG: D00307Help
Entry
D00307                      Drug                                   

Name
Doxycycline (USP);
Doxycycline hydrate;
DOXY;
Monodox (TN);
Oracea (TN)
Product
  Generic
DOXYCYCLINE MONOHYDRATE (Actavis Pharma), DOXYCYCLINE (American Health Packaging), DOXYCYCLINE MONOHYDRATE (Bryant Ranch Prepack), DOXYCYCLINE (Cardinal Health), DOXYCYCLINE (Elorac), DOXYCYCLINE (Elorac), DOXYCYCLINE (Global Pharmaceuticals), DOXYCYCLINE (Heritage Pharmaceuticals), DOXYCYCLINE (KAISER FOUNDATION HOSPITALS), DOXYCYCLINE (KAISER FOUNDATION HOSPITALS), DOXYCYCLINE (Lannett Company), DOXYCYCLINE (Lupin Pharmaceuticals), DOXYCYCLINE (Lupin Pharmaceuticals), DOXYCYCLINE (Mylan Pharmaceuticals), DOXYCYCLINE (Mylan Pharmaceuticals), DOXYCYCLINE MONOHYDRATE (PD-Rx Pharmaceuticals), DOXYCYCLINE (Par Pharmaceutical), DOXYCYCLINE (Par Pharmaceutical), ADOXA (PharmaDerm a division of Fougera Pharmaceuticals), ORACEA (Physicians Total Care), DOXYCYCLINE MONOHYDRATE (Physicians Total Care), DOXYCYCLINE (Proficient Rx LP), DOXYCYCLINE (REMEDYREPACK), DOXYCYCLINE (REMEDYREPACK), DOXYCYCLINE (REMEDYREPACK), DOXYCYCLINE (REMEDYREPACK), DOXYCYCLINE (REMEDYREPACK), DOXYCYCLINE (REMEDYREPACK), DOXYCYCLINE (REMEDYREPACK), DOXYCYCLINE (Ranbaxy Pharmaceuticals), DOXYCYCLINE (Ranbaxy Pharmaceuticals)
  Other
Formula
C22H24N2O8. H2O
Exact mass
462.1638
Mol weight
462.4498
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Antibacterial [DS:H00310 H00322]
Remark
ATC code: 
Drug group: 
Comment
Semisynthetic tetracycline
Target
16S rRNA of 30S ribosomal subunit, protein synthesis inhibitor [KO:K01977]
  Pathway
ko03010  Ribosome  
 
Interaction
Drug interaction
Structure map
Tetracyclines
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 J ANTIINFECTIVES FOR SYSTEMIC USE
  J01 ANTIBACTERIALS FOR SYSTEMIC USE
   J01A TETRACYCLINES
    J01AA Tetracyclines
     J01AA02 Doxycycline
      D00307  Doxycycline (USP)
USP drug classification [BR:br08302]
 Antibacterials
  Tetracyclines
   Doxycycline
    D00307  Doxycycline (USP)
 Dental and Oral Agents
  Doxycycline
   D00307  Doxycycline (USP)
 Dermatological Agents
  Doxycycline
   D00307  Doxycycline (USP)
Antiinfectives [BR:br08307]
 Antibacterials
  Protein biosynthesis inhibitor
   16S rRNA of 30S ribosomal subunit inhibitor
    Tetracyclines
     Doxycycline
      D00307  Doxycycline (USP)
BRITE hierarchy
Other DBs
CAS: 
17086-28-1
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        33
            1   C1y C    21.1216  -16.6614
            2   C1z C    21.1506  -18.0502
            3   C1y C    22.3391  -15.9818
            4   C1y C    19.9277  -15.9523
            5   C2y C    19.8983  -18.7358
            6   C5x C    22.2978  -18.7653
            7   C2y C    23.5269  -16.6969
            8   C1y C    18.7103  -16.6379
            9   C2y C    18.6985  -18.0324
            10  O1a O    19.8924  -20.1364
            11  C2y C    23.5151  -18.0857
            12  O5x O    22.3208  -20.1660
            13  O1a O    24.7564  -16.0173
            14  C1y C    17.5048  -15.9345
            15  C5x C    17.4929  -18.7298
            16  C5a C    24.7149  -18.8068
            17  C8y C    16.2990  -16.6261
            18  C8y C    16.2931  -18.0265
            19  O5x O    17.4929  -20.1245
            20  N1a N    25.9383  -18.1212
            21  O5a O    24.7439  -20.2073
            22  C8x C    15.0755  -15.9286
            23  C8y C    15.0815  -18.7240
            24  C8x C    13.8699  -16.6319
            25  C8x C    13.8699  -18.0324
            26  O1a O    15.0815  -20.1245
            27  C1a C    17.5101  -14.1705
            28  N1c N    22.3622  -13.7280
            29  C1a C    23.5981  -13.0412
            30  C1a C    21.1494  -13.0011
            31  O1a O    19.9173  -14.1846
            32  O1a O    21.0956  -19.4620
            33  O0  O    29.6802  -17.2901
BOND        35
            1     5   9 2
            2     5  10 1
            3     6  11 1
            4     6  12 2
            5     7  13 1
            6     8  14 1
            7     9  15 1
            8    11  16 1
            9    14  17 1
            10   15  18 1
            11   15  19 2
            12   16  20 1
            13   16  21 2
            14   17  22 1
            15   18  23 1
            16   22  24 2
            17   23  25 2
            18   23  26 1
            19    7  11 2
            20    8   9 1
            21   17  18 2
            22   24  25 1
            23   14  27 1 #Down
            24    3  28 1 #Down
            25    1   2 1
            26   28  29 1
            27    1   3 1
            28   28  30 1
            29    1   4 1
            30    2   5 1
            31    2   6 1
            32    4  31 1 #Down
            33    3   7 1
            34    2  32 1 #Down
            35    4   8 1

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