KEGG   DRUG: DroperidolHelp
Entry
D00308                      Drug                                   

Name
Droperidol (JP17/USP/INN);
Droleptan (TN);
Inapsine (TN)
Product
  Generic
Formula
C22H22FN3O2
Exact mass
379.1696
Mol weight
379.4274
Structure
Mol fileKCF fileDB searchJmolKegDraw
Simcomp SIMCOMP
Class
Neuropsychiatric agent
 DG01940  Butyrophenone derivative
 DG01478  Dopamine antagonist
  DG01474  Dopamine D2-receptor antagonist
Remark
Therapeutic category: 
ATC code: 
Activity
Anesthetic (intravenous), Antipsychotic
Comment
Butyrophenone derivative
Target
DRD2 [HSA:1813] [KO:K04145]
  Pathway
Neuroactive ligand-receptor interaction
Gap junction
Interaction
Drug interaction
Structure map
Butyrophenones
Dopamine receptor agonists/antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N05 PSYCHOLEPTICS
   N05A ANTIPSYCHOTICS
    N05AD Butyrophenone derivatives
     N05AD08 Droperidol
      D00308  Droperidol (JP17/USP/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  11  Agents affecting central nervous system
   111  General anesthetics
    1119  Others
     D00308  Droperidol (JP17/USP/INN)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Dopamine
    dopamine D2-receptor
     Droperidol
      D00308  Droperidol (JP17/USP/INN)
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D00308  Droperidol
Anesthetics, analgesics and anti-inflammatory drugs [br08369.html]
 Anesthetics
  D00308
BRITE hierarchy
Other DBs
CAS: 
548-73-2
PubChem: 
ChEBI: 
ChEMBL: 
DrugBank: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        28
            1   N4y N    34.7898  -14.1599
            2   C8y C    36.1337  -14.5455
            3   C2y C    33.5782  -14.8648
            4   C8y C    34.7636  -12.7484
            5   C8y C    36.9382  -13.4028
            6   C8x C    36.7369  -15.8127
            7   C1x C    33.5782  -16.2626
            8   C2x C    32.3726  -14.1599
            9   N4x N    36.0849  -12.2909
            10  O5x O    33.6158  -11.9504
            11  C8x C    38.3329  -13.5172
            12  C8x C    38.1331  -15.9387
            13  C1x C    32.3726  -16.9615
            14  C1x C    31.1553  -14.8648
            15  C8x C    38.9302  -14.7851
            16  N1y N    31.1612  -16.2626
            17  C1b C    29.9498  -16.9615
            18  C1b C    28.7325  -16.2626
            19  C1b C    27.5210  -16.9615
            20  C5a C    26.3037  -16.2626
            21  C8y C    25.0923  -16.9615
            22  O5a O    26.3037  -14.8648
            23  C8x C    23.8807  -16.2626
            24  C8x C    25.0923  -18.3593
            25  C8x C    22.6693  -16.9615
            26  C8x C    23.8866  -19.0642
            27  C8y C    22.6752  -18.3652
            28  X   F    21.4636  -19.0699
BOND        31
            1     1   2 1
            2     1   3 1
            3     1   4 1
            4     2   5 2
            5     2   6 1
            6     3   7 1
            7     3   8 2
            8     4   9 1
            9     4  10 2
            10    5  11 1
            11    6  12 2
            12    7  13 1
            13    8  14 1
            14   11  15 2
            15   13  16 1
            16   16  17 1
            17   17  18 1
            18   18  19 1
            19   19  20 1
            20   20  21 1
            21   20  22 2
            22   21  23 2
            23   21  24 1
            24   23  25 1
            25   24  26 2
            26   25  27 2
            27   27  28 1
            28    5   9 1
            29   12  15 1
            30   14  16 1
            31   26  27 1

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