KEGG   DRUG: D00310Help
Entry
D00310                      Drug                                   

Name
Enoxacin (USAN/INN);
ENX;
Penetrex (TN)
Formula
C15H17FN4O3
Exact mass
320.1285
Mol weight
320.3189
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Antibacterial
Remark
Same as: 
ATC code: 
Drug group: 
Target
DNA gyrase inhibitor [KO:K02469 K02470];
topoisomerase IV inhibitor [KO:K02621 K02622]
Metabolism
Enzyme: CYP3A4 [HSA:1576]
Interaction
CYP inhibition: CYP1A2 [HSA:1544]
Drug interaction
Structure map
Quinolones
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 J ANTIINFECTIVES FOR SYSTEMIC USE
  J01 ANTIBACTERIALS FOR SYSTEMIC USE
   J01M QUINOLONE ANTIBACTERIALS
    J01MA Fluoroquinolones
     J01MA04 Enoxacin
      D00310  Enoxacin (USAN/INN)
Antiinfectives [BR:br08307]
 Antibacterials
  Nucleic acid synthesis inhibitor
   type II topoisomerase (DNA gyrase, topoisomerase IV) inhibitor
    Fluoroquinolones
     Enoxacin
      D00310  Enoxacin (USAN/INN)
    Other quinolones
     Enoxacin
      D00310  Enoxacin (USAN/INN)
Cytochrome P450 interactions [BR:br08309]
 Substrates
  CYP1A2
   Enoxacin
    D00310  Enoxacin (USAN/INN)
  CYP3A4
   Enoxacin
    D00310  Enoxacin (USAN/INN)
 Inhbitors
  CYP1A2
   Enoxacin
    D00310  Enoxacin (USAN/INN)
   Enoxacin
    D00310  Enoxacin (USAN/INN)
BRITE hierarchy
Other DBs
CAS: 
74011-58-8
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        23
            1   C8y C    22.3469  -17.3424
            2   C8y C    22.3528  -15.9491
            3   N4y N    23.5535  -18.0535
            4   N5x N    21.1462  -18.0535
            5   C8y C    23.5652  -15.2613
            6   C8x C    21.1462  -15.2496
            7   C8x C    24.7660  -17.3598
            8   C1b C    23.5418  -19.4523
            9   C8y C    19.9337  -17.3481
            10  C8y C    24.7718  -15.9608
            11  O5x O    23.5768  -13.8566
            12  C8y C    19.9279  -15.9434
            13  C1a C    22.3236  -20.1461
            14  N1y N    18.7154  -18.0476
            15  C6a C    25.9958  -15.2730
            16  X   F    18.7154  -15.2496
            17  C1x C    18.7154  -19.4523
            18  C1x C    17.5030  -17.3424
            19  O6a O    27.2024  -15.9784
            20  O6a O    26.0017  -13.8682
            21  C1x C    17.5030  -20.1461
            22  C1x C    16.2907  -18.0476
            23  N1x N    16.2907  -19.4523
BOND        25
            1     1   2 2
            2     1   3 1
            3     1   4 1
            4     2   5 1
            5     2   6 1
            6     3   7 1
            7     3   8 1
            8     4   9 2
            9     5  10 1
            10    5  11 2
            11    6  12 2
            12    8  13 1
            13    9  14 1
            14   10  15 1
            15   12  16 1
            16   14  17 1
            17   14  18 1
            18   15  19 1
            19   15  20 2
            20   17  21 1
            21   18  22 1
            22   21  23 1
            23    7  10 2
            24    9  12 1
            25   22  23 1

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