KEGG   DRUG: D00311Help
Entry
D00311                      Drug                                   
Name
Estazolam (JP16/USAN/INN);
ProSom (TN)
Product
  Generic
Formula
C16H11ClN4
Exact mass
294.0672
Mol weight
294.7383
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Sedative-hypnotic
Remark
Same as: 
Therapeutic category: 
ATC code: 
Comment
Benzodiazepines
Target
GABAA-receptor (benzodiazepine binding site) agonist [HSA:2554 2555 2556 2557 2558 2559 2560 2561 2562 2563 2564 2565 2566 2567 2568 55879] [KO:K05175 K05181 K05184 K05185 K05186 K05189 K05192]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04727  GABAergic synapse  
 
Metabolism
Enzyme: CYP3A4 [HSA:1576]
Interaction
Drug interaction
Structure map
Hypnotics
GABA-A receptor agonists/antagonists
Brite
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  11  Agents affecting central nervous system
   112  Hypnotics and sedatives, anxiolytics
    1124  Benzodiazepins
     D00311  Estazolam (JP16/USAN/INN)
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N05 PSYCHOLEPTICS
   N05C HYPNOTICS AND SEDATIVES
    N05CD Benzodiazepine derivatives
     N05CD04 Estazolam
      D00311  Estazolam (JP16/USAN/INN)
Target-based classification of drugs [BR:br08310]
 Ion channels
  Cys-loop superfamily
   GABA-A
    GABAA-receptor (benzodiazepine binding site) [HSA:2554 2555 2556 2557 2558 2559 2560 2561 2562 2563 2564 2565 2566 2567 2568 55879] [KO:K05175 K05176 K05177 K05178 K05179 K05180 K05181 K05182 K05183 K05184 K05185 K05186 K05187 K05188 K05189 K05192]
     Estazolam [ATC:N05CD04]
      D00311  Estazolam (JP16/USAN/INN)
BRITE hierarchy
Other DBs
CAS: 
29975-16-4
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        21
            1   C2y C    14.0634  -14.3594
            2   C8y C    13.2213  -13.2498
            3   C8y C    13.5565  -11.8930
            4   N4y N    14.8175  -11.3149
            5   N2x N    15.4692  -14.3846
            6   C8y C    16.0711  -11.9372
            7   C1x C    16.3576  -13.3059
            8   C8x C    12.5494  -10.9246
            9   C8x C    11.2074  -11.3127
            10  C8y C    10.8722  -12.6695
            11  C8x C    11.8793  -13.6376
            12  X   Cl    9.5074  -13.0639
            13  C8y C    13.4289  -15.6091
            14  C8x C    12.0273  -15.6091
            15  C8x C    11.3273  -16.8216
            16  C8x C    12.0273  -18.0340
            17  C8x C    13.4289  -18.0340
            18  C8x C    14.1289  -16.8216
            19  N5x N    17.0504  -10.9373
            20  N5x N    16.4020   -9.5570
            21  C8x C    14.8175   -9.9149
BOND        24
            1     3   4 1
            2     1   5 2
            3     4   6 1
            4     2   3 1
            5     5   7 1
            6     1   2 1
            7     6   7 1
            8     3   8 2
            9     8   9 1
            10    9  10 2
            11   10  11 1
            12    2  11 2
            13   10  12 1
            14    1  13 1
            15   13  14 1
            16   14  15 2
            17   15  16 1
            18   16  17 2
            19   17  18 1
            20   13  18 2
            21    6  19 2
            22   19  20 1
            23    4  21 1
            24   21  20 2

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