KEGG   DRUG: D00318Help
Entry
D00318                      Drug                                   
Name
Famotidine (JP16/USP/INN);
Fluxid (TN);
Pepcid (TN)
Product
  Generic
FAMOTIDINE (APP Pharmaceuticals), FAMOTIDINE (APP Pharmaceuticals), FAMOTIDINE (American Health Packaging), FAMOTIDINE (Baxter Healthcare Corporation), FAMOTIDINE (Bryant Ranch Prepack), FAMOTIDINE (Cardinal Health), FAMOTIDINE (Cardinal Health), FAMOTIDINE (Cardinal Health), FAMOTIDINE (Cardinal Health), FAMOTIDINE (Carlsbad Technology), FAMOTIDINE (Dr.Reddy's Laboratories Limited), FAMOTIDINE (GAVIS Pharmaceuticals), FAMOTIDINE (Golden State Medical Supply), FAMOTIDINE (IVAX Pharmaceuticals), FAMOTIDINE (Lake Erie Medical & Surgical Supply DBA Quality Care Products LLC), FAMOTIDINE (Lake Erie Medical DBA Quality Care Products LLC), FAMOTIDINE (Legacy Pharmaceutical Packaging), FAMOTIDINE (Lupin Pharmaceuticals), FAMOTIDINE (Major Pharmaceuticals), PEPCID (Marathon Pharmaceuticals), FAMOTIDINE (McKesson Contract Packaging), FAMOTIDINE (McKesson Packaging Services Business Unit of McKesson Corporation), FAMOTIDINE (McKesson Packaging Services Business Unit of McKesson Corporation), FAMOTIDINE (Mylan Institutional), FAMOTIDINE (Mylan Pharmaceuticals), FAMOTIDINE (NCS HealthCare of KY), FAMOTIDINE (NCS HealthCare of KY), FAMOTIDINE (NorthStar RxLLC), FAMOTIDINE (Novel Laboratories), FAMOTIDINE (PD-Rx Pharmaceuticals), FAMOTIDINE (PD-Rx Pharmaceuticals), FAMOTIDINE (Pfizer Laboratories Div Pfizer), FAMOTIDINE (Physicians Total Care), FAMOTIDINE (Preferred Pharmaceuticals), FAMOTIDINE (Preferred Pharmaceuticals), FAMOTIDINE (REMEDYREPACK), FAMOTIDINE (REMEDYREPACK), FAMOTIDINE (REMEDYREPACK), FAMOTIDINE (STAT Rx USA LLC), FAMOTIDINE (West-ward Pharmaceutical Corp.), FAMOTIDINE (Wockhardt Limited), FAMOTIDINE (Wockhardt USA LLC.), FAMOTIDINE (Zydus Pharmaceuticals USA)
Formula
C8H15N7O2S3
Exact mass
337.0449
Mol weight
337.4454
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Antagonist [to histamine H2 receptors]
Remark
Therapeutic category: 
ATC code: 
Target
H2-receptor antagonist [HSA:3274] [KO:K04150]
  Pathway
hsa04020  Calcium signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04971  Gastric acid secretion  
 
Metabolism
Transporter: SLC22A2 [HSA:6582], SLC22A8 [HSA:9376]
Interaction
CYP inhibition: CYP1A2 [HSA:1544]
Transporter inhibition: SLC22A2 [HSA:6582], SLC22A3 [HSA:6581]
Drug interaction
Pathway map
Bile secretion
Structure map
Antiulcer drugs
2-Aminothiazole family
Histamine H2/H3 receptor agonists/antagonists
Brite
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  23  Digestive organ agents
   232  Peptic ulcer agents
    2325  H2 blockers
     D00318  Famotidine (JP16/USP/INN)
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 A ALIMENTARY TRACT AND METABOLISM
  A02 DRUGS FOR ACID RELATED DISORDERS
   A02B DRUGS FOR PEPTIC ULCER AND GASTRO-OESOPHAGEAL REFLUX DISEASE (GORD)
    A02BA H2-receptor antagonists
     A02BA03 Famotidine
      D00318  Famotidine (JP16/USP/INN)
USP drug classification [BR:br08302]
 Gastrointestinal Agents
  Histamine2 (H2) receptor Antagonists
   Famotidine
    D00318  Famotidine (JP16/USP/INN)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Histamine
    H2-receptor [HSA:3274] [KO:K04150]
     Famotidine [ATC:A02BA03]
      D00318  Famotidine (JP16/USP/INN)
BRITE hierarchy
Other DBs
CAS: 
76824-35-6
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        20
            1   C1b C    21.2100  -23.8000
            2   S2a S    22.4700  -23.1000
            3   C1b C    23.6600  -23.8000
            4   C1b C    24.8500  -23.1000
            5   C2c C    26.1100  -23.8000
            6   N2b N    27.3000  -23.1000
            7   C8y C    20.0200  -23.1000
            8   N5x N    20.0200  -21.7000
            9   C8y C    18.6900  -21.2800
            10  S2x S    17.8500  -22.4000
            11  C8x C    18.6900  -23.5200
            12  N2b N    18.2620  -19.9470
            13  C2c C    16.9019  -19.6530
            14  N1a N    15.9389  -20.7155
            15  N1a N    16.4756  -18.3267
            16  N1a N    26.1272  -25.1999
            17  S4a S    28.5181  -23.7901
            18  O3c O    29.6995  -23.0950
            19  O3c O    28.4598  -25.1994
            20  N1a N    29.7021  -24.5005
BOND        20
            1     1   2 1
            2     2   3 1
            3     3   4 1
            4     4   5 1
            5     5   6 2
            6     1   7 1
            7     7   8 1
            8     8   9 2
            9     9  10 1
            10   10  11 1
            11    7  11 2
            12    9  12 1
            13   12  13 2
            14   13  14 1
            15   13  15 1
            16    5  16 1
            17    6  17 1
            18   17  18 2
            19   17  19 2
            20   17  20 1

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