KEGG   DRUG: FelodipineHelp
Entry
D00319                      Drug                                   

Name
Felodipine (JAN/USP/INN);
Plendil (TN)
Product
  Generic
FELODIPINE (A-S Medication Solutions), FELODIPINE (American Health Packaging), FELODIPINE (Aurobindo Pharma Limited), FELODIPINE (Bryant Ranch Prepack), FELODIPINE (Bryant Ranch Prepack), FELODIPINE (Carilion Materials Management), FELODIPINE (Carilion Materials Management), FELODIPINE (Citron Pharma LLC), FELODIPINE (Glenmark Pharmaceuticals), FELODIPINE (HERITAGE PHARMACEUTICALS), FELODIPINE (Medsource Pharmaceuticals), FELODIPINE (Medsource Pharmaceuticals), FELODIPINE (Mutual Pharmaceutical Company), FELODIPINE (Mylan Institutional), FELODIPINE (Mylan Pharmaceuticals), FELODIPINE (NCS HealthCare of KY), FELODIPINE (PD-Rx Pharmaceuticals), FELODIPINE (Physicians Total Care), FELODIPINE (Qualitest Pharmaceuticals), FELODIPINE (REMEDYREPACK), FELODIPINE (Richmond Pharmaceuticals), FELODIPINE (Torrent Pharmaceuticals Limited), FELODIPINE (WOCKHARDT LIMITED), FELODIPINE (WOCKHARDT USA LLC)
Formula
C18H19Cl2NO4
Exact mass
383.0691
Mol weight
384.2538
Structure
Mol fileKCF fileDB searchJmolKegDraw
Class
Other
 DG01575  Calcium channel blocker
  DG01496  Calcium channel L type blocker
Cyp substrate
 DG01633  CYP3A4 substrate
Remark
Therapeutic category: 
ATC code: 
Activity
Vasodilator
Target
calcium channel L type [HSA:775 776 778 779] [KO:K04850 K04851 K04853 K04857]
  Pathway
MAPK signaling pathway
Calcium signaling pathway
Cardiac muscle contraction
Vascular smooth muscle contraction
Metabolism
Enzyme: CYP3A4 [HSA:1576], CYP3A5 [HSA:1577], CYP3A7 [HSA:1551]
Interaction
Transporter inhibition: ABCB1 [HSA:5243]
Drug interaction
Structure map
Calcium channel blocking drugs
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 C CARDIOVASCULAR SYSTEM
  C08 CALCIUM CHANNEL BLOCKERS
   C08C SELECTIVE CALCIUM CHANNEL BLOCKERS WITH MAINLY VASCULAR EFFECTS
    C08CA Dihydropyridine derivatives
     C08CA02 Felodipine
      D00319  Felodipine (JAN/USP/INN)
USP drug classification [BR:br08302]
 Cardiovascular Agents
  Calcium Channel Blocking Agents
   Felodipine
    D00319  Felodipine (JAN/USP/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  21  Cardiovascular agents
   214  Antihypertensives
    2149  Others
     D00319  Felodipine (JAN/USP/INN)
Target-based classification of drugs [BR:br08310]
 Ion channels
  Voltage-gated cation channels
   Ca2+ channel, CACN alpha-1, CaVx.x
    calcium channel L type
     Felodipine
      D00319  Felodipine (JAN/USP/INN)
Cytochrome P450 interactions [BR:br08309]
 CYP substrates
  CYP3A4
   Felodipine
    D00319  Felodipine (JAN/USP/INN)
  CYP3A5
   Felodipine
    D00319  Felodipine (JAN/USP/INN)
  CYP3A7
   Felodipine
    D00319  Felodipine (JAN/USP/INN)
  CYP3A
   Felodipine
    D00319  Felodipine (JAN/USP/INN)
 Transporter inhibitors
  ABCB1
   Felodipine
    D00319  Felodipine (JAN/USP/INN)
Cardiovascular agents [br08364.html]
 Antihypertensives
  D00319
BRITE hierarchy
Other DBs
CAS: 
72509-76-3
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        25
            1   C1y C    23.3929  -16.6407
            2   C8y C    23.3752  -18.9159
            3   C2y C    22.2113  -15.9623
            4   C2y C    24.5742  -15.9682
            5   C8y C    22.1879  -19.5944
            6   C8x C    24.5567  -19.6061
            7   C2y C    22.2173  -14.5937
            8   C7a C    21.0240  -16.6350
            9   C2y C    24.5801  -14.6054
            10  C7a C    25.7498  -16.6524
            11  C8y C    22.1879  -20.9630
            12  X   Cl   21.0066  -18.9101
            13  C8x C    24.5508  -20.9630
            14  N1x N    23.3986  -13.9152
            15  C1a C    21.0357  -13.9095
            16  O7a O    19.8485  -15.9565
            17  O6a O    21.0240  -18.0093
            18  C1a C    25.7615  -13.9212
            19  O7a O    26.9371  -15.9799
            20  O6a O    25.7440  -18.0210
            21  C8x C    23.3635  -21.6473
            22  X   Cl   21.0006  -21.6473
            23  C1b C    18.6671  -16.6350
            24  C1a C    28.1186  -16.6641
            25  C1a C    17.4856  -15.9506
BOND        26
            1     1   2 1
            2     1   3 1
            3     1   4 1
            4     2   5 2
            5     2   6 1
            6     3   7 2
            7     3   8 1
            8     4   9 2
            9     4  10 1
            10    5  11 1
            11    5  12 1
            12    6  13 2
            13    7  14 1
            14    7  15 1
            15    8  16 1
            16    8  17 2
            17    9  18 1
            18   10  19 1
            19   10  20 2
            20   11  21 2
            21   11  22 1
            22   16  23 1
            23   19  24 1
            24   23  25 1
            25    9  14 1
            26   13  21 1

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