KEGG   DRUG: D00319Help
Entry
D00319                      Drug                                   

Name
Felodipine (JAN/USP/INN);
Plendil (TN)
Product
  Generic
Formula
C18H19Cl2NO4
Exact mass
383.0691
Mol weight
384.2538
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Vasodilator
Remark
Therapeutic category: 
ATC code: 
Target
calcium channel L type blocker [HSA:775 776 778 779] [KO:K04850 K04851 K04853 K04857]
  Pathway
hsa04010  MAPK signaling pathway
hsa04020  Calcium signaling pathway
hsa04260  Cardiac muscle contraction
hsa04270  Vascular smooth muscle contraction  
 
Metabolism
Enzyme: CYP3A4 [HSA:1576], CYP3A5 [HSA:1577], CYP3A7 [HSA:1551]
Interaction
Transporter inhibition: ABCB1 [HSA:5243]
Drug interaction
Structure map
Calcium channel blocking drugs
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 C CARDIOVASCULAR SYSTEM
  C08 CALCIUM CHANNEL BLOCKERS
   C08C SELECTIVE CALCIUM CHANNEL BLOCKERS WITH MAINLY VASCULAR EFFECTS
    C08CA Dihydropyridine derivatives
     C08CA02 Felodipine
      D00319  Felodipine (JAN/USP/INN)
USP drug classification [BR:br08302]
 Cardiovascular Agents
  Calcium Channel Blocking Agents
   Felodipine
    D00319  Felodipine (JAN/USP/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  21  Cardiovascular agents
   214  Antihypertensives
    2149  Others
     D00319  Felodipine (JAN/USP/INN)
Target-based classification of drugs [BR:br08310]
 Ion channels
  Voltage-gated cation channels
   Ca2+ channel, CACN alpha-1, CaVx.x
    calcium channel L type
     Felodipine
      D00319  Felodipine (JAN/USP/INN)
Cytochrome P450 interactions [BR:br08309]
 Substrates
  CYP3A4
   Felodipine
    D00319  Felodipine (JAN/USP/INN)
  CYP3A5
   Felodipine
    D00319  Felodipine (JAN/USP/INN)
  CYP3A7
   Felodipine
    D00319  Felodipine (JAN/USP/INN)
BRITE hierarchy
Other DBs
CAS: 
72509-76-3
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        25
            1   C1y C    23.3929  -16.6407
            2   C8y C    23.3752  -18.9159
            3   C2y C    22.2113  -15.9623
            4   C2y C    24.5742  -15.9682
            5   C8y C    22.1879  -19.5944
            6   C8x C    24.5567  -19.6061
            7   C2y C    22.2173  -14.5937
            8   C7a C    21.0240  -16.6350
            9   C2y C    24.5801  -14.6054
            10  C7a C    25.7498  -16.6524
            11  C8y C    22.1879  -20.9630
            12  X   Cl   21.0066  -18.9101
            13  C8x C    24.5508  -20.9630
            14  N1x N    23.3986  -13.9152
            15  C1a C    21.0357  -13.9095
            16  O7a O    19.8485  -15.9565
            17  O6a O    21.0240  -18.0093
            18  C1a C    25.7615  -13.9212
            19  O7a O    26.9371  -15.9799
            20  O6a O    25.7440  -18.0210
            21  C8x C    23.3635  -21.6473
            22  X   Cl   21.0006  -21.6473
            23  C1b C    18.6671  -16.6350
            24  C1a C    28.1186  -16.6641
            25  C1a C    17.4856  -15.9506
BOND        26
            1     1   2 1
            2     1   3 1
            3     1   4 1
            4     2   5 2
            5     2   6 1
            6     3   7 2
            7     3   8 1
            8     4   9 2
            9     4  10 1
            10    5  11 1
            11    5  12 1
            12    6  13 2
            13    7  14 1
            14    7  15 1
            15    8  16 1
            16    8  17 2
            17    9  18 1
            18   10  19 1
            19   10  20 2
            20   11  21 2
            21   11  22 1
            22   16  23 1
            23   19  24 1
            24   23  25 1
            25    9  14 1
            26   13  21 1

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