KEGG   DRUG: D00321Help
Entry
D00321                      Drug                                   

Name
Finasteride (JAN/USP/INN);
Propecia (TN);
Proscar (TN)
Product
  Generic
FINASTERIDE (Accord Healthcare), FINASTERIDE (Accord Healthcare), FINASTERIDE (Actavis), FINASTERIDE (Actavis Pharma), FINASTERIDE (Aidarex Pharmaceuticals LLC), FINASTERIDE (American Health Packaging), FINASTERIDE (Aurobindo Pharma Limited), FINASTERIDE (Aurobindo Pharma Limited), FINASTERIDE (AvKARE), FINASTERIDE (AvPAK), FINASTERIDE (Bryant Ranch Prepack), FINASTERIDE (Bryant Ranch Prepack), FINASTERIDE (Camber Pharmaceuticals), FINASTERIDE (Camber Pharmaceuticals), FINASTERIDE (Camber Pharmaceuticals), FINASTERIDE (Cardinal Health), FINASTERIDE (Citron Pharma LLC), FINASTERIDE (Citron Pharma LLC), FINASTERIDE (Clinical Solutions Wholesale), FINASTERIDE (Dr Reddys Laboratories), FINASTERIDE (Dr Reddys Laboratories), FINASTERIDE (Dr. Reddy's Laboratories Limited), FINASTERIDE (Dr. Reddy's Laboratories Limited), FINASTERIDE (Exelan Pharmaceuticals), FINASTERIDE (Greenstone LLC), FINASTERIDE (Hetero Drugs Limited), FINASTERIDE (Ingenus Pharmaceuticals), FINASTERIDE (Legacy Pharmaceutical Packaging), FINASTERIDE (McKesson Packaging Services Business Unit of McKesson Corporation), FINASTERIDE (Mylan Institutional), FINASTERIDE (Mylan Pharmaceuticals), FINASTERIDE (New Horizon Rx Group), FINASTERIDE (NorthStar Rx LLC), FINASTERIDE (NorthStar Rx LLC), FINASTERIDE (Physicians Total Care), FINASTERIDE (Preferred Pharmaceuticals), FINASTERIDE (Preferred Pharmaceuticals), FINASTERIDE (Qualitest Pharmaceuticals), FINASTERIDE (REMEDYREPACK), FINASTERIDE (REMEDYREPACK), FINASTERIDE (REMEDYREPACK), FINASTERIDE (Sun Pharma Global FZE), FINASTERIDE (Sun Pharma Global FZE), FINASTERIDE (Teva Pharmaceuticals USA), FINASTERIDE (Unit Dose Services)
Formula
C23H36N2O2
Exact mass
372.2777
Mol weight
372.5441
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Inhibitor [alpha reductase]
Remark
Therapeutic category: 
ATC code: 
Target
5alpha-reductase inhibitor [HSA:6715 6716 79644] [KO:K12343 K12344 K12345]
  Pathway
hsa00140  Steroid hormone biosynthesis  
 
Metabolism
Enzyme: CYP3A4 [HSA:1576]
Interaction
Drug interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 D DERMATOLOGICALS
  D11 OTHER DERMATOLOGICAL PREPARATIONS
   D11A OTHER DERMATOLOGICAL PREPARATIONS
    D11AX Other dermatologicals
     D11AX10 Finasteride
      D00321  Finasteride (JAN/USP/INN)
 G GENITO URINARY SYSTEM AND SEX HORMONES
  G04 UROLOGICALS
   G04C DRUGS USED IN BENIGN PROSTATIC HYPERTROPHY
    G04CB Testosterone-5-alpha reductase inhibitors
     G04CB01 Finasteride
      D00321  Finasteride (JAN/USP/INN)
USP drug classification [BR:br08302]
 Genitourinary Agents
  Benign Prostatic Hypertrophy Agents
   Finasteride
    D00321  Finasteride (JAN/USP/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  24  Hormones
   249  Miscellaneous
    2499  Others
     D00321  Finasteride (JAN/USP/INN)
Target-based classification of drugs [BR:br08310]
 Enzymes
  Oxidoreductases
   5alpha-reductase 1
    Finasteride
     D00321  Finasteride (JAN/USP/INN)
   5alpha-reductase 2
    Finasteride
     D00321  Finasteride (JAN/USP/INN)
   5alpha-reductase 3
    Finasteride
     D00321  Finasteride (JAN/USP/INN)
Cytochrome P450 interactions [BR:br08309]
 Substrates
  CYP3A4
   Finasteride
    D00321  Finasteride (JAN/USP/INN)
   Finasteride
    D00321  Finasteride (JAN/USP/INN)
BRITE hierarchy
Other DBs
CAS: 
98319-26-7
PubChem: 
DrugBank: 
PDB-CCD: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        27
            1   C1y C    25.2062  -19.0694
            2   C1y C    24.0333  -19.7462
            3   C1z C    25.2236  -17.7159
            4   C1x C    27.5515  -19.0985
            5   C1y C    22.8607  -19.0518
            6   C1x C    24.0333  -21.1054
            7   C1y C    26.4022  -17.0506
            8   C1x C    24.0567  -17.0274
            9   C1a C    25.2469  -16.2980
            10  C1x C    27.5689  -17.7450
            11  C1z C    21.6763  -19.7345
            12  C1x C    22.8723  -17.6983
            13  C1x C    22.8490  -21.7765
            14  C5a C    26.3963  -15.6563
            15  C1y C    21.6706  -21.0938
            16  C2x C    20.4979  -19.0518
            17  C1a C    21.6822  -18.3576
            18  N1b N    25.2293  -14.9621
            19  O5a O    27.5865  -14.9912
            20  N1x N    20.4979  -21.7705
            21  C2x C    19.3252  -19.7345
            22  C1d C    24.0567  -14.1919
            23  C5x C    19.3252  -21.0938
            24  C1a C    22.9600  -13.5035
            25  C1a C    23.2924  -15.2304
            26  C1a C    24.8094  -13.0893
            27  O5x O    18.1409  -21.7705
BOND        30
            1     1   2 1
            2     1   3 1
            3     1   4 1
            4     2   5 1
            5     2   6 1
            6     3   7 1
            7     3   8 1
            8     3   9 1 #Up
            9     4  10 1
            10    5  11 1
            11    5  12 1
            12    6  13 1
            13    7  14 1 #Up
            14   11  15 1
            15   11  16 1
            16   11  17 1 #Up
            17   14  18 1
            18   14  19 2
            19   15  20 1
            20   16  21 2
            21   18  22 1
            22   20  23 1
            23   22  24 1
            24   22  25 1
            25   22  26 1
            26   23  27 2
            27    7  10 1
            28    8  12 1
            29   13  15 1
            30   21  23 1

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