KEGG   DRUG: D00331Help
Entry
D00331                      Drug                                   

Name
Furosemide (JP16/USP/INN);
Frusemide;
Lasix (TN)
Product
FUROSEMIDE (APP Pharmaceuticals), FUROSEMIDE (American Regent), FUROSEMIDE (Aphena Pharma Solutions - Tennessee), FUROSEMIDE (Aphena Pharma Solutions - Tennessee), FUROSEMIDE (Aphena Pharma Solutions - Tennessee), FUROSEMIDE (Cardinal Health), FUROSEMIDE (Cardinal Health), FUROSEMIDE (Clinical Solutions Wholesale), FUROSEMIDE (Contract Pharmacy Services-PA), FUROSEMIDE (DAVA Pharmaceuticals), FUROSEMIDE (General Injectables & Vaccines), FUROSEMIDE (General Injectables & Vaccines), FUROSEMIDE (Hospira), FUROSEMIDE (IVAX Pharmaceuticals), FUROSEMIDE (Major Pharmaceuticals), FUROSEMIDE (McKesson Packaging Services Business unit of McKesson Corporation), FUROSEMIDE (Mylan Institutional), FUROSEMIDE (Mylan Pharmaceuticals), FUROSEMIDE (NCS HealthCare of KY), FUROSEMIDE (NCS HealthCare of KY), FUROSEMIDE (Preferred Pharmaceuticals), FUROSEMIDE (REMEDYREPACK), FUROSEMIDE (REMEDYREPACK), FUROSEMIDE (REMEDYREPACK), FUROSEMIDE (REMEDYREPACK), FUROSEMIDE (REMEDYREPACK), FUROSEMIDE (REMEDYREPACK), FUROSEMIDE (REMEDYREPACK), FUROSEMIDE (REMEDYREPACK), FUROSEMIDE (Roxane Laboratories), FUROSEMIDE (Sandoz), LASIX (Sanofi-Aventis U.S. LLC), FUROSEMIDE (State of Florida DOH Central Pharmacy)
  Generic
FUROSEMIDE (A-S Medication Solutions LLC), FUROSEMIDE (A-S Medication Solutions LLC), FUROSEMIDE (Aidarex Pharmaceuticals LLC), FUROSEMIDE (American Health Packaging), FUROSEMIDE (Aphena Pharma Solutions - Tennessee), FUROSEMIDE (Blenheim Pharmacal), FUROSEMIDE (Bryant Ranch Prepack), FUROSEMIDE (Bryant Ranch Prepack), FUROSEMIDE (Bryant Ranch Prepack), FUROSEMIDE (Cardinal Health), FUROSEMIDE (Cardinal Health), FUROSEMIDE (Cardinal Health), FUROSEMIDE (Cardinal Health), FUROSEMIDE (Cardinal Health), FUROSEMIDE (Cardinal Health), FUROSEMIDE (Cardinal Health), FUROSEMIDE (Cardinal Health), FUROSEMIDE (Cardinal Health), FUROSEMIDE (Cardinal Health), FUROSEMIDE (Claris Lifesciences), FUROSEMIDE (Clinical Solutions Wholesale), FUROSEMIDE (Contract Pharmacy Services-PA), FUROSEMIDE (Contract Pharmacy Services-PA), FUROSEMIDE (Excellium Pharmaceutical), FUROSEMIDE (General Injectables & Vaccines), FUROSEMIDE (General Injectables & Vaccines), FUROSEMIDE (Ingenus Pharmaceuticals), FUROSEMIDE (Lake Erie Medical & Surgical Supply DBA Quality Care Products LLC), FUROSEMIDE (Lake Erie Medical DBA Quality Care Products LLC), FUROSEMIDE (McKesson Contract Packaging), FUROSEMIDE (McKesson Contract Packaging), FUROSEMIDE (McKesson Packaging Services Business Unit of McKesson Corporation), FUROSEMIDE (McKesson Packaging Services a business unit of McKesson Corporation), FUROSEMIDE (MedVantx), FUROSEMIDE (MedVantx), FUROSEMIDE (Morton Grove Pharmaceuticals), FUROSEMIDE (New Horizon Rx Group), FUROSEMIDE (PD-Rx Pharmaceuticals), FUROSEMIDE (PD-Rx Pharmaceuticals), FUROSEMIDE (PD-Rx Pharmaceuticals), FUROSEMIDE (PD-Rx Pharmaceuticals), FUROSEMIDE (Physicians Total Care), FUROSEMIDE (Physicians Total Care), FUROSEMIDE (Precision Dose), FUROSEMIDE (Preferred Pharmaceuticals), FUROSEMIDE (Preferred Pharmaceuticals), FUROSEMIDE (Proficient Rx LP), FUROSEMIDE (Qualitest Pharmaceuticals), FUROSEMIDE (REMEDYREPACK), FUROSEMIDE (REMEDYREPACK), FUROSEMIDE (REMEDYREPACK), FUROSEMIDE (REMEDYREPACK), FUROSEMIDE (REMEDYREPACK), FUROSEMIDE (REMEDYREPACK), FUROSEMIDE (REMEDYREPACK), FUROSEMIDE (Ranbaxy Pharmaceuticals), FUROSEMIDE (ReadyMeds), FUROSEMIDE (Rebel Distirbutors Corp), FUROSEMIDE (Rebel Distributors Corp), FUROSEMIDE (RedPharm Drug), FUROSEMIDE (STAT Rx USA LLC), FUROSEMIDE (St Marys Medical Park Pharmacy), FUROSEMIDE (State of Florida DOH Central Pharmacy), FUROSEMIDE (State of Florida DOH Central Pharmacy), FUROSEMIDE (State of Florida DOH Central Pharmacy), FUROSEMIDE (Unit Dose Services), FUROSEMIDE (Unit Dose Services)
Formula
C12H11ClN2O5S
Exact mass
330.0077
Mol weight
330.7441
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Diuretic
Remark
Same as: 
Therapeutic category: 
ATC code: 
Drug group: 
Comment
Loop diuretic
Target
Na-K-Cl cotransporter 1 inhibitor [HSA:6557] [KO:K14425];
Na-K-Cl cotransporter 2 inhibitor [HSA:6558] [KO:K10951];
GABAA-receptor alpha antagonist [HSA:2554 2555 2556 2557 2558 2559] [KO:K05175]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04727  GABAergic synapse  
 
Metabolism
Transporter: SLC22A6 [HSA:9356], SLC22A8 [HSA:9376], ABCC4 [HSA:10257]
Interaction
Drug interaction
Structure map
Sulfonamide derivatives - diuretics
Sulfonamide derivatives - overview
Ion transporter inhibitors
Other map
Bile secretion
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 C CARDIOVASCULAR SYSTEM
  C03 DIURETICS
   C03C HIGH-CEILING DIURETICS
    C03CA Sulfonamides, plain
     C03CA01 Furosemide
      D00331  Furosemide (JP16/USP/INN)
USP drug classification [BR:br08302]
 Cardiovascular Agents
  Diuretics, Loop
   Furosemide
    D00331  Furosemide (JP16/USP/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  21  Cardiovascular agents
   213  Diuretics
    2139  Others
     D00331  Furosemide (JP16/USP/INN)
Target-based classification of drugs [BR:br08310]
 Ion channels
  Cys-loop superfamily
   GABA-A
    GABAA-receptor alpha
     Furosemide
      D00331  Furosemide (JP16/USP/INN)
 Transporters
  Solute carrier family
   SLC12
    SLC12A1
     Furosemide
      D00331  Furosemide (JP16/USP/INN)
    SLC12A2
     Furosemide
      D00331  Furosemide (JP16/USP/INN)
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D00331  Furosemide
  D00331  Furosemide tablets
  D00331  Furosemide injection
BRITE hierarchy
Other DBs
CAS: 
54-31-9
PubChem: 
DrugBank: 
PDB-CCD: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        21
            1   C8y C    33.0198  -14.5445
            2   C8y C    31.8035  -15.2369
            3   C8x C    34.2301  -15.2545
            4   C6a C    33.0314  -13.1420
            5   C8x C    31.7978  -16.6395
            6   N1b N    30.5932  -14.5270
            7   C8y C    34.2185  -16.6511
            8   O6a O    31.8211  -12.4379
            9   O6a O    34.2477  -12.4553
            10  C8y C    33.0024  -17.3436
            11  C1b C    29.3827  -15.2253
            12  S4a S    35.4290  -17.3552
            13  X   Cl   32.9965  -18.7402
            14  C8y C    28.1781  -14.5153
            15  N1a N    36.6336  -18.0652
            16  O3c O    34.7364  -18.5772
            17  O3c O    36.1506  -16.1623
            18  O2x O    28.1781  -13.1153
            19  C8x C    26.8466  -12.6826
            20  C8x C    26.0237  -13.8153
            21  C8x C    26.8466  -14.9479
BOND        22
            1     1   2 2
            2     1   3 1
            3     1   4 1
            4     2   5 1
            5     2   6 1
            6     3   7 2
            7     4   8 2
            8     4   9 1
            9     5  10 2
            10    6  11 1
            11    7  12 1
            12   10  13 1
            13   11  14 1
            14   12  15 1
            15   12  16 2
            16   12  17 2
            17    7  10 1
            18   14  18 1
            19   18  19 1
            20   19  20 2
            21   20  21 1
            22   14  21 2

» Japanese version   » Back

DBGET integrated database retrieval system