| Entry |
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| Name |
Furosemide (JP16/USP/INN);
Frusemide;
Lasix (TN)
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| Product |
FUROSEMIDE (APP Pharmaceuticals), FUROSEMIDE (Cardinal Health), FUROSEMIDE (Contract Pharmacy Services-PA), FUROSEMIDE (DAVA Pharmaceuticals), FUROSEMIDE (General Injectables & Vaccines), FUROSEMIDE (General Injectables & Vaccines), FUROSEMIDE (Hospira), FUROSEMIDE (IVAX Pharmaceuticals), FUROSEMIDE (Major Pharmaceuticals), FUROSEMIDE (McKesson Packaging Services Business unit of McKesson Corporation), FUROSEMIDE (Mylan Pharmaceuticals), FUROSEMIDE (NCS HealthCare of KY), FUROSEMIDE (Preferred Pharmaceuticals), FUROSEMIDE (REMEDYREPACK), FUROSEMIDE (REMEDYREPACK), FUROSEMIDE (REMEDYREPACK), FUROSEMIDE (REMEDYREPACK), FUROSEMIDE (Roxane Laboratories), FUROSEMIDE (Sandoz), LASIX (Sanofi-Aventis U.S. LLC), FUROSEMIDE (State of Florida DOH Central Pharmacy), FUROSEMIDE (UDL Laboratories) |
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| Generic |
FUROSEMIDE (American Health Packaging), FUROSEMIDE (American Regent), FUROSEMIDE (Bryant Ranch Prepack), FUROSEMIDE (Bryant Ranch Prepack), FUROSEMIDE (Bryant Ranch Prepack), FUROSEMIDE (Cardinal Health), FUROSEMIDE (Cardinal Health), FUROSEMIDE (Cardinal Health), FUROSEMIDE (Cardinal Health), FUROSEMIDE (Cardinal Health), FUROSEMIDE (Cardinal Health), FUROSEMIDE (Cardinal Health), FUROSEMIDE (Cardinal Health), FUROSEMIDE (Cardinal Health), FUROSEMIDE (Contract Pharmacy Services-PA), FUROSEMIDE (Contract Pharmacy Services-PA), FUROSEMIDE (Excellium Pharmaceutical), FUROSEMIDE (General Injectables & Vaccines), FUROSEMIDE (General Injectables & Vaccines), FUROSEMIDE (Ingenus Pharmaceuticals), FUROSEMIDE (Lake Erie Medical & Surgical Supply DBA Quality Care Products LLC), FUROSEMIDE (McKesson Contract Packaging), FUROSEMIDE (McKesson Contract Packaging), FUROSEMIDE (McKesson Packaging Services Business Unit of McKesson Corporation), FUROSEMIDE (McKesson Packaging Services a business unit of McKesson Corporation), FUROSEMIDE (MedVantx), FUROSEMIDE (MedVantx), FUROSEMIDE (Morton Grove Pharmaceuticals), FUROSEMIDE (NCS HealthCare of KY), FUROSEMIDE (PD-Rx Pharmaceuticals), FUROSEMIDE (PD-Rx Pharmaceuticals), FUROSEMIDE (PD-Rx Pharmaceuticals), FUROSEMIDE (PD-Rx Pharmaceuticals), FUROSEMIDE (Physicians Total Care), FUROSEMIDE (Physicians Total Care), FUROSEMIDE (Precision Dose), FUROSEMIDE (Precision Dose), FUROSEMIDE (Preferred Pharmaceuticals), FUROSEMIDE (Preferred Pharmaceuticals), FUROSEMIDE (Qualitest Pharmaceuticals), FUROSEMIDE (REMEDYREPACK), FUROSEMIDE (REMEDYREPACK), FUROSEMIDE (REMEDYREPACK), FUROSEMIDE (REMEDYREPACK), FUROSEMIDE (REMEDYREPACK), FUROSEMIDE (REMEDYREPACK), FUROSEMIDE (Ranbaxy Pharmaceuticals), FUROSEMIDE (Rebel Distirbutors Corp), FUROSEMIDE (Rebel Distributors Corp), FUROSEMIDE (RedPharm Drug), FUROSEMIDE (STAT Rx USA LLC), FUROSEMIDE (St Marys Medical Park Pharmacy), FUROSEMIDE (State of Florida DOH Central Pharmacy), FUROSEMIDE (Unit Dose Services), FUROSEMIDE (Unit Dose Services) |
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| Formula |
C12H11ClN2O5S
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| Exact mass |
330.0077
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| Mol weight |
330.7441
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| Structure |
     |
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| Activity |
Diuretic
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| Remark |
Same as: Therapeutic category: ATC code: |
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| Comment |
Loop diuretic
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| Target |
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| Pathway |
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| Metabolism |
Transporter: SLC22A6 [HSA: 9356], SLC22A8 [HSA: 9376], ABCC4 [HSA: 10257]
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| Interaction |
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| Pathway map |
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| Structure map |
| Sulfonamide derivatives - diuretics | | Ion transporter inhibitors |
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| Brite |
Therapeutic category of drugs in Japan [BR:br08301]
2 Agents affecting individual organs
21 Cardiovascular agents
213 Diuretics
2139 Others
D00331 Furosemide (JP16/USP/INN)
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
C CARDIOVASCULAR SYSTEM
C03 DIURETICS
C03C HIGH-CEILING DIURETICS
C03CA Sulfonamides, plain
C03CA01 Furosemide
D00331 Furosemide (JP16/USP/INN)
USP drug classification [BR:br08302]
Cardiovascular Agents
Diuretics, Loop
Furosemide
D00331 Furosemide (JP16/USP/INN)
Target-based classification of drugs [BR:br08310]
Ion channels
Cys-loop superfamily
GABA-A
GABAA-receptor alpha [HSA:2554 2555 2556 2557 2558 2559] [KO:K05175 K05176 K05177 K05178 K05179 K05180]
Furosemide [ATC:C03CA01]
D00331 Furosemide (JP16/USP/INN)
Transporters
Solute carrier family
SLC12
SLC12A1 [HSA:6557] [KO:K14425]
Furosemide [ATC:C03CA01]
D00331 Furosemide (JP16/USP/INN)
SLC12A2 [HSA:6558] [KO:K10951] [TC:2.A.30.3.1]
Furosemide [ATC:C03CA01]
D00331 Furosemide (JP16/USP/INN)
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| Other DBs |
CAS: 54-31-9 PubChem: DrugBank: PDB-CCD: LigandBox: NIKKAJI: |
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| KCF data |
ATOM 21
1 C8y C 33.0198 -14.5445
2 C8y C 31.8035 -15.2369
3 C8x C 34.2301 -15.2545
4 C6a C 33.0314 -13.1420
5 C8x C 31.7978 -16.6395
6 N1b N 30.5932 -14.5270
7 C8y C 34.2185 -16.6511
8 O6a O 31.8211 -12.4379
9 O6a O 34.2477 -12.4553
10 C8y C 33.0024 -17.3436
11 C1b C 29.3827 -15.2253
12 S4a S 35.4290 -17.3552
13 X Cl 32.9965 -18.7402
14 C8y C 28.1781 -14.5153
15 N1a N 36.6336 -18.0652
16 O3c O 34.7364 -18.5772
17 O3c O 36.1506 -16.1623
18 O2x O 28.1781 -13.1153
19 C8x C 26.8466 -12.6826
20 C8x C 26.0237 -13.8153
21 C8x C 26.8466 -14.9479
BOND 22
1 1 2 2
2 1 3 1
3 1 4 1
4 2 5 1
5 2 6 1
6 3 7 2
7 4 8 2
8 4 9 1
9 5 10 2
10 6 11 1
11 7 12 1
12 10 13 1
13 11 14 1
14 12 15 1
15 12 16 2
16 12 17 2
17 7 10 1
18 14 18 1
19 18 19 1
20 19 20 2
21 20 21 1
22 14 21 2
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