KEGG   DRUG: D00340Help
Entry
D00340                      Drug                                   

Name
Hydrochlorothiazide (JP16/USP/INN);
Esidrix (TN);
Microzide (TN)
Product
  Generic
HYDROCHLOROTHIAZIDE (A-S Medication Solutions LLC), HYDROCHLOROTHIAZIDE (Accord Healthcare), HYDROCHLOROTHIAZIDE (Actavis Elizabeth LLC), HYDROCHLOROTHIAZIDE (Aidarex Pharmaceuticals LLC), HYDROCHLOROTHIAZIDE (Aidarex Pharmaceuticals LLC), HYDROCHLOROTHIAZIDE (American Health Packaging), HYDROCHLOROTHIAZIDE (American Health Packaging), HYDROCHLOROTHIAZIDE (Apotex Corp.), HYDROCHLOROTHIAZIDE (Apotex Corp.), HYDROCHLOROTHIAZIDE (Apotheca), HYDROCHLOROTHIAZIDE (Aurobindo Pharma Limited), HYDROCHLOROTHIAZIDE (Aurobindo Pharma Limited), HYDROCHLOROTHIAZIDE (Blenheim Pharmacal), HYDROCHLOROTHIAZIDE (Blenheim Pharmacal), HYDROCHLOROTHIAZIDE (Bryant Ranch Prepack), HYDROCHLOROTHIAZIDE (Bryant Ranch Prepack), HYDROCHLOROTHIAZIDE (Bryant Ranch Prepack), HYDROCHLOROTHIAZIDE (Cardinal Health), HYDROCHLOROTHIAZIDE (Cardinal Health), HYDROCHLOROTHIAZIDE (Cardinal Health), HYDROCHLOROTHIAZIDE (Cardinal Health), HYDROCHLOROTHIAZIDE (Cardinal Health), HYDROCHLOROTHIAZIDE (Citron Pharma LLC), HYDROCHLOROTHIAZIDE (Clinical Solutions Wholesale), HYDROCHLOROTHIAZIDE (Contract Pharmacy Services-PA), HYDROCHLOROTHIAZIDE (Contract Pharmacy Services-PA), HYDROCHLOROTHIAZIDE (Contract Pharmacy Services-PA), HYDROCHLOROTHIAZIDE (DAVA Pharmaceuticals), HYDROCHLOROTHIAZIDE (Dispensing Solutions), HYDROCHLOROTHIAZIDE (Excellium Pharmaceutical), HYDROCHLOROTHIAZIDE (Greenstone LLC), HYDROCHLOROTHIAZIDE (Greenstone LLC), HYDROCHLOROTHIAZIDE (H.J. Harkins Company), HYDROCHLOROTHIAZIDE (Heritage Pharmaceuticals), HYDROCHLOROTHIAZIDE (Heritage Pharmaceuticals), HYDROCHLOROTHIAZIDE (Heritage Pharmaceuticals), HYDROCHLOROTHIAZIDE (Heritage Pharmaceuticals), HYDROCHLOROTHIAZIDE (IVAX Pharmaceuticals), HYDROCHLOROTHIAZIDE (International Labs), HYDROCHLOROTHIAZIDE (International Labs), HYDROCHLOROTHIAZIDE (JUBILANT CADISTA PHARMACEUTICALS), HYDROCHLOROTHIAZIDE (JUBILANT CADISTA PHARMACEUTICALS), HYDROCHLOROTHIAZIDE (KAISER FOUNDATION HOSPITALS), HYDROCHLOROTHIAZIDE (Lake Erie Medical & Surgical Supply DBA Quality Care Products LLC), HYDROCHLOROTHIAZIDE (Lake Erie Medical & Surgical Supply DBA Quality Care Products LLC), HYDROCHLOROTHIAZIDE (Lake Erie Medical & Surgical Supply DBA Quality Care Products LLC), HYDROCHLOROTHIAZIDE (Lake Erie Medical DBA Quality Care Products LLC), HYDROCHLOROTHIAZIDE (Lake Erie Medical DBA Quality Care Products LLC), HYDROCHLOROTHIAZIDE (Lannett Company), HYDROCHLOROTHIAZIDE (Lannett Company), HYDROCHLOROTHIAZIDE (Legacy Pharmaceutical Packaging), HYDROCHLOROTHIAZIDE (Legacy Pharmaceutical Packaging), HYDROCHLOROTHIAZIDE (Liberty Pharmaceuticals), HYDROCHLOROTHIAZIDE (Life Line Home Care Services), HYDROCHLOROTHIAZIDE (McKesson Contract Packaging), HYDROCHLOROTHIAZIDE (McKesson Contract Packaging), HYDROCHLOROTHIAZIDE (McKesson Packaging Services a business unit of McKesson Corporation), HYDROCHLOROTHIAZIDE (Med-Health Pharma), HYDROCHLOROTHIAZIDE (MedVantx), HYDROCHLOROTHIAZIDE (MedVantx), HYDROCHLOROTHIAZIDE (Mylan Pharmaceuticals), HYDROCHLOROTHIAZIDE (NCS HealthCare of KY), HYDROCHLOROTHIAZIDE (NCS HealthCare of KY), HYDROCHLOROTHIAZIDE (NorthStar RxLLC), HYDROCHLOROTHIAZIDE (PD-Rx Pharmaceuticals), HYDROCHLOROTHIAZIDE (PD-Rx Pharmaceuticals), HYDROCHLOROTHIAZIDE (PD-Rx Pharmaceuticals), HYDROCHLOROTHIAZIDE (PD-Rx Pharmaceuticals), HYDROCHLOROTHIAZIDE (PD-Rx Pharmaceuticals), HYDROCHLOROTHIAZIDE (Physicians Total Care), HYDROCHLOROTHIAZIDE (Physicians Total Care), HYDROCHLOROTHIAZIDE (Preferred Pharmaceuticals), HYDROCHLOROTHIAZIDE (Preferred Pharmaceuticals), HYDROCHLOROTHIAZIDE (Preferred Pharmaceuticals), HYDROCHLOROTHIAZIDE (Qualitest Pharmaceuticals), HYDROCHLOROTHIAZIDE (Qualitest Pharmaceuticals), HYDROCHLOROTHIAZIDE (REMEDYREPACK), HYDROCHLOROTHIAZIDE (REMEDYREPACK), HYDROCHLOROTHIAZIDE (REMEDYREPACK), HYDROCHLOROTHIAZIDE (REMEDYREPACK), HYDROCHLOROTHIAZIDE (REMEDYREPACK), HYDROCHLOROTHIAZIDE (REMEDYREPACK), HYDROCHLOROTHIAZIDE (REMEDYREPACK), HYDROCHLOROTHIAZIDE (REMEDYREPACK), HYDROCHLOROTHIAZIDE (REMEDYREPACK), HYDROCHLOROTHIAZIDE (REMEDYREPACK), HYDROCHLOROTHIAZIDE (REMEDYREPACK), HYDROCHLOROTHIAZIDE (REMEDYREPACK), HYDROCHLOROTHIAZIDE (REMEDYREPACK), HYDROCHLOROTHIAZIDE (REMEDYREPACK), HYDROCHLOROTHIAZIDE (REMEDYREPACK), HYDROCHLOROTHIAZIDE (REMEDYREPACK), HYDROCHLOROTHIAZIDE (REMEDYREPACK), HYDROCHLOROTHIAZIDE (REMEDYREPACK), HYDROCHLOROTHIAZIDE (REMEDYREPACK), HYDROCHLOROTHIAZIDE (REMEDYREPACK), HYDROCHLOROTHIAZIDE (REMEDYREPACK), HYDROCHLOROTHIAZIDE (REMEDYREPACK), HYDROCHLOROTHIAZIDE (Rebel Distributors Corp), HYDROCHLOROTHIAZIDE (Rebel Distributors Corp), HYDROCHLOROTHIAZIDE (Rebel Distributors Corp), HYDROCHLOROTHIAZIDE (Rebel Distributors Corp), HYDROCHLOROTHIAZIDE (RedPharm Drug), HYDROCHLOROTHIAZIDE (STAT RX USA LLC), HYDROCHLOROTHIAZIDE (STAT RX USA LLC), HYDROCHLOROTHIAZIDE (STAT Rx USA LLC), HYDROCHLOROTHIAZIDE (St Marys Medical Park Pharmacy), HYDROCHLOROTHIAZIDE (St Marys Medical Park Pharmacy), HYDROCHLOROTHIAZIDE (St Marys Medical Park Pharmacy), HYDROCHLOROTHIAZIDE (State of Florida DOH Central Pharmacy), HYDROCHLOROTHIAZIDE (State of Florida DOH Central Pharmacy), HYDROCHLOROTHIAZIDE (State of Florida DOH Central Pharmacy), HYDROCHLOROTHIAZIDE (Teva Pharmaceuticals USA), HYDROCHLOROTHIAZIDE (UDL Laboratories), HYDROCHLOROTHIAZIDE (Unichem Pharmaceuticals (USA)), HYDROCHLOROTHIAZIDE (Unichem Pharmaceuticals (USA)), HYDROCHLOROTHIAZIDE (Unit Dose Services), HYDROCHLOROTHIAZIDE (Unit Dose Services), HYDROCHLOROTHIAZIDE (Unit Dose Services), HYDROCHLOROTHIAZIDE (Watson Laboratories), HYDROCHLOROTHIAZIDE (West-ward Pharmaceutical Corp), HYDROCHLOROTHIAZIDE (West-ward Pharmaceutical Corp)
Formula
C7H8ClN3O4S2
Exact mass
296.9645
Mol weight
297.7391
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Diuretic
Remark
Same as: 
Therapeutic category: 
ATC code: 
Target
Na+-Cl- symport inhibitor [HSA:6559] [KO:K14426]
Interaction
Drug interaction
Structure map
Sulfonamide derivatives - diuretics
Ion transporter inhibitors
Other map
Bile secretion
Brite
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  21  Cardiovascular agents
   213  Diuretics
    2132  Thiazides
     D00340  Hydrochlorothiazide (JP16/USP/INN)
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 C CARDIOVASCULAR SYSTEM
  C03 DIURETICS
   C03A LOW-CEILING DIURETICS, THIAZIDES
    C03AA Thiazides, plain
     C03AA03 Hydrochlorothiazide
      D00340  Hydrochlorothiazide (JP16/USP/INN)
USP drug classification [BR:br08302]
 Cardiovascular Agents
  Diuretics, Thiazide
   Hydrochlorothiazide
    D00340  Hydrochlorothiazide (JP16/USP/INN)
Target-based classification of drugs [BR:br08310]
 Transporters
  Solute carrier family
   SLC12
    SLC12A3 [HSA:6559] [KO:K14426] [TC:2.A.30.4.2]
     Hydrochlorothiazide [ATC:03AA03]
      D00340  Hydrochlorothiazide (JP16/USP/INN)
BRITE hierarchy
Other DBs
CAS: 
58-93-5
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        17
            1   C8y C    22.4791  -15.9596
            2   C8y C    22.4731  -17.3165
            3   C8x C    23.6605  -15.2870
            4   S2x S    21.3034  -15.2811
            5   C8x C    23.6430  -18.0010
            6   N1x N    21.3034  -17.9950
            7   C8y C    24.8304  -15.9713
            8   N1x N    20.1278  -15.9596
            9   O3c O    19.9933  -14.4564
            10  O3c O    22.5376  -14.4564
            11  C8y C    24.8244  -17.3282
            12  C1x C    20.1278  -17.3165
            13  S4a S    26.0118  -15.2987
            14  X   Cl   26.0003  -18.0127
            15  N1a N    27.2636  -14.4623
            16  O3c O    27.1349  -16.3164
            17  O3c O    24.9357  -14.2516
BOND        18
            1     1   2 2
            2     1   3 1
            3     1   4 1
            4     2   5 1
            5     2   6 1
            6     3   7 2
            7     4   8 1
            8     4   9 2
            9     4  10 2
            10    5  11 2
            11    6  12 1
            12    7  13 1
            13   11  14 1
            14   13  15 1
            15   13  16 2
            16   13  17 2
            17    7  11 1
            18    8  12 1

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