KEGG   DRUG: D00341Help
Entry
D00341                      Drug                                   

Name
Hydroxycarbamide (JAN/INN);
Hydroxyurea (USP);
Droxia (TN);
Hydrea (TN)
Product
  Generic
Formula
CH4N2O2
Exact mass
76.0273
Mol weight
76.0547
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Antineoplastic [DS:H00004 H00012 H00229]
Remark
Same as: 
Therapeutic category: 
ATC code: 
Target
ribonucleotide reductase M2 inhibitor [HSA:6241] [KO:K10808]
  Pathway
hsa00230  Purine metabolism
hsa00240  Pyrimidine metabolism
hsa00480  Glutathione metabolism
hsa04115  p53 signaling pathway  
 
Interaction
Drug interaction
Structure map
Antineoplastics - antimetabolic agents
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 L ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
  L01 ANTINEOPLASTIC AGENTS
   L01X OTHER ANTINEOPLASTIC AGENTS
    L01XX Other antineoplastic agents
     L01XX05 Hydroxycarbamide
      D00341  Hydroxycarbamide (JAN/INN); Hydroxyurea (USP)
USP drug classification [BR:br08302]
 Antineoplastics
  Antimetabolites
   Hydroxyurea
    D00341  Hydroxycarbamide (JAN/INN); Hydroxyurea (USP)
Therapeutic category of drugs in Japan [BR:br08301]
 4  Agents affecting cellular function
  42  Antineoplastics
   422  Antimetabolites
    4229  Others
     D00341  Hydroxycarbamide (JAN/INN); Hydroxyurea (USP)
Target-based classification of drugs [BR:br08310]
 Enzymes
  Oxidoreductases
   ribonucleotide reductase M2
    Hydroxycarbamide
     D00341  Hydroxycarbamide (JAN/INN); Hydroxyurea (USP)
Antineoplastics [BR:br08308]
 Miscellaneous agents
  Substitued urea
   Hydroxycarbamide
    D00341  Hydroxycarbamide (JAN/INN); Hydroxyurea (USP)
BRITE hierarchy
Other DBs
CAS: 
127-07-1
PubChem: 
DrugBank: 
PDB-CCD: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        5
            1   C5a C    25.2773  -18.3400
            2   N1b N    26.4812  -19.0436
            3   N1a N    24.0675  -19.0436
            4   O5a O    25.2773  -16.9385
            5   O1b O    27.6967  -18.3400
BOND        4
            1     1   2 1
            2     1   3 1
            3     1   4 2
            4     2   5 1

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