KEGG   DRUG: D00346Help
Entry
D00346                      Drug                                   

Name
Isoniazid (JP16/USP/INN);
Laniazid (TN)
Product
  Generic
ISONIAZID (A-S Medication Solutions LLC), ISONIAZID (A-S Medication Solutions LLC), ISONIAZID (Barr Laboratories), ISONIAZID (Blenheim Pharmacal), ISONIAZID (Bryant Ranch Prepack), ISONIAZID (Bryant Ranch Prepack), ISONIAZID (Bryant Ranch Prepack), ISONIAZID (Carolina Medical Products Company), ISONIAZID (Clinical Solutions Wholesale), ISONIAZID (Contract Pharmacy Services-PA), ISONIAZID (H.J. Harkins Company), ISONIAZID (Lannett Company), ISONIAZID (Liberty Pharmaceuticals), ISONIAZID (Liberty Pharmaceuticals), ISONIAZID (Major Pharmaceuticals), ISONIAZID (PD-Rx Pharmaceuticals), ISONIAZID (PD-Rx Pharmaceuticals), ISONIAZID (PD-Rx Pharmaceuticals), ISONIAZID (Physicians Total Care), ISONIAZID (Preferred Pharmaceuticals), ISONIAZID (REMEDYREPACK), ISONIAZID (REMEDYREPACK), ISONIAZID (REMEDYREPACK), ISONIAZID (REMEDYREPACK), ISONIAZID (REMEDYREPACK), ISONIAZID (REMEDYREPACK), ISONIAZID (REMEDYREPACK), ISONIAZID (Rebel Distributors Corp), ISONIAZID (STAT RX USA LLC), ISONIAZID (Sandoz), ISONIAZID (UDL Laboratories), ISONIAZID (VersaPharm Incorporated), ISONIAZID (West-ward Pharmaceutical Corp)
Formula
C6H7N3O
Exact mass
137.0589
Mol weight
137.1393
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Antibacterial [tuberculostatic] [DS:H00342]
Remark
Same as: 
Therapeutic category: 
ATC code: 
Drug group: 
Target
enoyl-[acyl-carrier-protein] reductase (NADH) [KO:K11611];
monoamine oxidase (MAO) inhibitor [HSA:4128 4129] [KO:K00274]
Interaction
CYP induction: CYP2E1 [HSA:1571]
CYP inhibition: CYP2C9 [HSA:1559], CYP3A [HSA:1576 1577 1551]
Drug interaction
Structure map
Catecholamine transferase inhibitors
Other map
Drug metabolism - other enzymes
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 J ANTIINFECTIVES FOR SYSTEMIC USE
  J04 ANTIMYCOBACTERIALS
   J04A DRUGS FOR TREATMENT OF TUBERCULOSIS
    J04AC Hydrazides
     J04AC01 Isoniazid
      D00346  Isoniazid (JP16/USP/INN)
USP drug classification [BR:br08302]
 Antimycobacterials
  Antituberculars
   Isoniazid
    D00346  Isoniazid (JP16/USP/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 6  Agents against pathologic organisms and parasites
  62  Chemotherapeutics
   622  Tuberculosis preparations
    6222  Isoniazids
     D00346  Isoniazid (JP16/USP/INN)
Target-based classification of drugs [BR:br08310]
 Enzymes
  Oxidoreductases
   monoamine oxidase (MAO)
    Isoniazid
     D00346  Isoniazid (JP16/USP/INN)
Antiinfectives [BR:br08307]
 Antibacterials
  Cell wall biosynthesis inhibitor
   Others
    enoyl-[acyl-carrier-protein] reductase (NADH) inhibitor
     Isoniazid
      D00346  Isoniazid (JP16/USP/INN)
Cytochrome P450 interactions [BR:br08309]
 Inhbitors
  CYP2C9
   Isoniazid
    D00346  Isoniazid (JP16/USP/INN)
  CYP3A
   Isoniazid
    D00346  Isoniazid (JP16/USP/INN)
 Inducers
  CYP2E1
   Isoniazid
    D00346  Isoniazid (JP16/USP/INN)
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D00346  Isoniazid
  D00346  Isoniazid tablets
  D00346  Isoniazid injection
BRITE hierarchy
Other DBs
CAS: 
54-85-3
PubChem: 
DrugBank: 
PDB-CCD: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        10
            1   C8y C    22.4877  -16.7300
            2   C5a C    23.6995  -17.4291
            3   C8x C    21.2816  -17.4291
            4   C8x C    22.4877  -15.3316
            5   N1b N    24.9115  -16.7300
            6   O5a O    23.6995  -18.8275
            7   C8x C    20.0638  -16.7300
            8   C8x C    21.2816  -14.6266
            9   N1a N    26.1293  -17.4291
            10  N5x N    20.0638  -15.3316
BOND        10
            1     1   2 1
            2     1   3 2
            3     1   4 1
            4     2   5 1
            5     2   6 2
            6     3   7 1
            7     4   8 2
            8     5   9 1
            9     7  10 2
            10    8  10 1

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