KEGG   DRUG: D00354Help
Entry
D00354                      Drug                                   

Name
Lamotrigine (JAN/USAN/INN);
Lamictal (TN)
Product
  Generic
LAMOTRIGINE (Aidarex Pharmaceuticals LLC), LAMOTRIGINE (Aidarex Pharmaceuticals LLC), LAMOTRIGINE (American Health Packaging), LAMOTRIGINE (American Health Packaging), LAMOTRIGINE (Apotex Corp), LAMOTRIGINE (Ascend Laboratories), LAMOTRIGINE (Aurobindo Pharma Limited), LAMOTRIGINE (Aurobindo Pharma Limited), LAMOTRIGINE (AvKARE), LAMOTRIGINE (Bryant Ranch Prepack), LAMOTRIGINE (Bryant Ranch Prepack), LAMOTRIGINE (Bryant Ranch Prepack), LAMOTRIGINE (Bryant Ranch Prepack), LAMOTRIGINE (Cadila Healthcare Limited), LAMOTRIGINE (Cardinal Health), LAMOTRIGINE (Cardinal Health), LAMOTRIGINE (Cardinal Health), LAMOTRIGINE (Carilion Materials Management), LAMOTRIGINE (Cipla Limited), LAMOTRIGINE (Clinical Solutions Wholesale), LAMOTRIGINE (Cobalt Laboratories), LAMOTRIGINE (Dr. Reddy's Laboratories Limited), LAMOTRIGINE (Dr.Reddy's Laboratories Limited), LAMOTRIGINE (Dr.Reddy's Laboratories Limited), LAMOTRIGINE (Glenmark Generics), LAMOTRIGINE (Glenmark Generics), LAMOTRIGINE (Hikma Pharmaceutical), LAMOTRIGINE (JUBILANT CADISTA PHARMACEUTICALS), LAMOTRIGINE (Jubilant Cadista Pharmaceuticals), LAMOTRIGINE (Lake Erie Medical & Surgical Supply DBA Quality Care Products LLC), LAMOTRIGINE (McKesson Contract Packaging), LAMOTRIGINE (McKesson Packaging Services Business Unit of McKesson Corporation), LAMOTRIGINE (McKesson Packaging Services a buisness unit of McKesson Corporation), LAMOTRIGINE (McKesson Packaging Sevices a business unit of McKesson Corporation), LAMOTRIGINE (Mylan Institutional), LAMOTRIGINE (Mylan Pharmaceuticals), LAMOTRIGINE (Mylan Pharmaceuticals), LAMOTRIGINE (NCS HealthCare of KY), LAMOTRIGINE (NorthStar RxLLC), LAMOTRIGINE (PD-Rx Pharmaceuticals), LAMOTRIGINE (PD-Rx Pharmaceuticals), LAMOTRIGINE (PD-Rx Pharmaceuticals), LAMOTRIGINE (PD-Rx Pharmaceuticals), LAMOTRIGINE (Physicians Total Care), LAMOTRIGINE (Preferred Pharmaceuticals), LAMOTRIGINE (REMEDYREPACK), LAMOTRIGINE (REMEDYREPACK), LAMOTRIGINE (REMEDYREPACK), LAMOTRIGINE (REMEDYREPACK), LAMOTRIGINE (REMEDYREPACK), LAMOTRIGINE (REMEDYREPACK), LAMOTRIGINE (REMEDYREPACK), LAMOTRIGINE (REMEDYREPACK), LAMOTRIGINE (REMEDYREPACK), LAMOTRIGINE (REMEDYREPACK), LAMOTRIGINE (REMEDYREPACK), LAMOTRIGINE (REMEDYREPACK), LAMOTRIGINE (REMEDYREPACK), LAMOTRIGINE (REMEDYREPACK), LAMOTRIGINE (REMEDYREPACK), LAMOTRIGINE (REMEDYREPACK), LAMOTRIGINE (REMEDYREPACK), LAMOTRIGINE (REMEDYREPACK), LAMOTRIGINE (REMEDYREPACK), LAMOTRIGINE (REMEDYREPACK), LAMOTRIGINE (REMEDYREPACK), LAMOTRIGINE (REMEDYREPACK), LAMOTRIGINE (STAT RX USA LLC), LAMOTRIGINE (Sandoz), LAMOTRIGINE (TYA Pharmaceuticals), LAMOTRIGINE (Taro Pharmaceuticals U.S.A.), LAMOTRIGINE (Taro Pharmaceuticals U.S.A.), LAMOTRIGINE (Teva Pharmaceuticals USA), LAMOTRIGINE (Teva Pharmaceuticals USA), LAMOTRIGINE (Torrent Pharmaceuticals Limited), LAMOTRIGINE (Torrent Pharmaceuticals Limited), LAMOTRIGINE (Unichem Pharmaceuticals (USA)), LAMOTRIGINE (Unit Dose Services), LAMOTRIGINE (Unit Dose Services), LAMOTRIGINE (Upsher-Smith Laboratories), LAMOTRIGINE (Upsher-Smith Laboratories), LAMOTRIGINE (West-ward Pharmaceutical Corp), LAMOTRIGINE (Wilshire Pharmaceuticals), LAMOTRIGINE (Wockhardt Limited), LAMOTRIGINE (Wockhardt USA LLC.), LAMOTRIGINE (Zydus Pharmaceuticals (USA)), LAMOTRIGINE EXTENDED RELEASE (Par Pharmaceutical)
Formula
C9H7Cl2N5
Exact mass
255.0079
Mol weight
256.0914
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Anticonvulsant [DS:H00063 H00808]
Remark
Therapeutic category: 
ATC code: 
Target
voltage-gated sodium channel (SCN1A) blocker [HSA:6323] [KO:K04833];
voltage-gated sodium channel (SCN2A) blocker [HSA:6326] [KO:K04834];
voltage-gated sodium channel (SCN3A) blocker [HSA:6328] [KO:K04836];
voltage-gated sodium channel (SCN4A) blocker [HSA:6329] [KO:K04837];
voltage-gated sodium channel (SCN5A) blocker [HSA:6331] [KO:K04838];
voltage-gated sodium channel (SCN8A) blocker [HSA:6334] [KO:K04840];
voltage-gated sodium channel (SCN9A) blocker [HSA:6335] [KO:K04841]
Metabolism
Enzyme: UGT1A4 [HSA:54657]
Interaction
Drug interaction
Structure map
Anticonvulsants
Sodium channel blocking drugs
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N03 ANTIEPILEPTICS
   N03A ANTIEPILEPTICS
    N03AX Other antiepileptics
     N03AX09 Lamotrigine
      D00354  Lamotrigine (JAN/USAN/INN)
USP drug classification [BR:br08302]
 Anticonvulsants
  Glutamate Reducing Agents
   Lamotrigine
    D00354  Lamotrigine (JAN/USAN/INN)
 Bipolar Agents
  Mood Stabilizers
   Lamotrigine
    D00354  Lamotrigine (JAN/USAN/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  11  Agents affecting central nervous system
   113  Antiepileptics
    1139  Others
     D00354  Lamotrigine (JAN/USAN/INN)
Target-based classification of drugs [BR:br08310]
 Ion channels
  Voltage-gated cation channels
   Na+ channel, SCN alpha, NaV1.x
    voltage-gated sodium channel (SCN1A)
     Lamotrigine
      D00354  Lamotrigine (JAN/USAN/INN)
    voltage-gated sodium channel (SCN2A)
     Lamotrigine
      D00354  Lamotrigine (JAN/USAN/INN)
    voltage-gated sodium channel (SCN3A)
     Lamotrigine
      D00354  Lamotrigine (JAN/USAN/INN)
    voltage-gated sodium channel (SCN4A)
     Lamotrigine
      D00354  Lamotrigine (JAN/USAN/INN)
    voltage-gated sodium channel (SCN5A)
     Lamotrigine
      D00354  Lamotrigine (JAN/USAN/INN)
    voltage-gated sodium channel (SCN8A)
     Lamotrigine
      D00354  Lamotrigine (JAN/USAN/INN)
    voltage-gated sodium channel (SCN9A)
     Lamotrigine
      D00354  Lamotrigine (JAN/USAN/INN)
BRITE hierarchy
Other DBs
CAS: 
84057-84-1
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        16
            1   C8y C    21.7344  -17.9428
            2   C8y C    20.5227  -17.2321
            3   C8y C    21.7285  -19.3408
            4   N5x N    22.9459  -17.2378
            5   C8y C    20.5286  -15.8341
            6   C8x C    19.3053  -17.9311
            7   N5x N    22.9343  -20.0398
            8   N1a N    20.5111  -20.0281
            9   N5x N    24.1576  -17.9485
            10  C8y C    19.3169  -15.1350
            11  X   Cl   21.7461  -15.1467
            12  C8x C    18.0995  -17.2262
            13  C8y C    24.1517  -19.3465
            14  C8x C    18.0995  -15.8281
            15  X   Cl   19.3228  -13.7313
            16  N1a N    25.3633  -20.0513
BOND        17
            1     1   2 1
            2     1   3 2
            3     1   4 1
            4     2   5 2
            5     2   6 1
            6     3   7 1
            7     3   8 1
            8     4   9 2
            9     5  10 1
            10    5  11 1
            11    6  12 2
            12    7  13 2
            13   10  14 2
            14   10  15 1
            15   13  16 1
            16    9  13 1
            17   12  14 1

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