KEGG   DRUG: D00356Help
Entry
D00356                      Drug                                   

Name
Latanoprost (JAN/USAN/INN);
Xalatan (TN)
Product
  Generic
Formula
C26H40O5
Exact mass
432.2876
Mol weight
432.5928
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Antiglaucoma agent [DS:H00612]
Remark
Therapeutic category: 
ATC code: 
Target
prostaglandin F receptor agonist [HSA:5737] [KO:K04262]
  Pathway
hsa04020  Calcium signaling pathway
hsa04080  Neuroactive ligand-receptor interaction  
 
Interaction
Drug interaction
Structure map
Prostaglandins
Antiglaucoma agents
Eicosanoid receptor agonists/antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 S SENSORY ORGANS
  S01 OPHTHALMOLOGICALS
   S01E ANTIGLAUCOMA PREPARATIONS AND MIOTICS
    S01EE Prostaglandin analogues
     S01EE01 Latanoprost
      D00356  Latanoprost (JAN/USAN/INN)
USP drug classification [BR:br08302]
 Ophthalmic Agents
  Ophthalmic Prostaglandin and Prostamide Analogs
   Latanoprost
    D00356  Latanoprost (JAN/USAN/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  13  Agents affecting sensory organs
   131  Ophthalmic agents
    1319  Others
     D00356  Latanoprost (JAN/USAN/INN)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Prostaglandin
    prostaglandin F receptor
     Latanoprost
      D00356  Latanoprost (JAN/USAN/INN)
BRITE hierarchy
Other DBs
CAS: 
130209-82-4
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        31
            1   C1y C    18.8346  -20.3048
            2   C1y C    18.8346  -21.7052
            3   C1y C    17.4343  -19.8847
            4   C1b C    20.0249  -19.6046
            5   C1y C    17.5043  -22.1253
            6   C1b C    20.0249  -22.4054
            7   C1x C    16.6641  -21.0050
            8   C2b C    21.2152  -20.3048
            9   O1a O    17.0842  -23.5256
            10  C1b C    21.2152  -21.7052
            11  C1c C    22.4755  -22.4054
            12  C1b C    23.6658  -21.7052
            13  O1a O    22.4755  -23.8057
            14  C1b C    24.9261  -22.4054
            15  C8y C    24.9261  -23.8057
            16  C8x C    26.1164  -24.5059
            17  C8x C    26.1164  -25.9061
            18  C8x C    24.9261  -26.6063
            19  C8x C    23.6658  -25.9061
            20  C8x C    23.6658  -24.5059
            21  O1a O    16.9442  -18.5544
            22  C2b C    22.6156  -20.3048
            23  C1b C    23.8059  -19.6046
            24  C1b C    24.9961  -20.3048
            25  C1b C    26.1864  -19.6046
            26  C7a C    27.3767  -20.3048
            27  O7a O    28.5670  -19.6046
            28  C1c C    29.7573  -20.3048
            29  C1a C    30.9476  -19.6046
            30  O6a O    27.3767  -21.7052
            31  C1a C    29.7573  -21.7052
BOND        32
            1    12  14 1
            2     5   7 1
            3    14  15 1
            4     1   2 1
            5     1   3 1
            6     1   4 1 #Down
            7     2   5 1
            8     2   6 1 #Up
            9    15  16 2
            10   16  17 1
            11   17  18 2
            12   18  19 1
            13   19  20 2
            14   20  15 1
            15    3   7 1
            16    4   8 1
            17    5   9 1 #Down
            18    6  10 1
            19   10  11 1
            20   11  12 1
            21   11  13 1 #Down
            22    3  21 1 #Down
            23    8  22 2
            24   23  24 1
            25   23  22 1
            26   24  25 1
            27   25  26 1
            28   26  27 1
            29   27  28 1
            30   28  29 1
            31   26  30 2
            32   28  31 1

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