KEGG   DRUG: D00357Help
Entry
D00357                      Drug                                   

Name
Losartan potassium (JP16/USAN);
Cozaar (TN)
Product
  Generic
LOSORTAN POTASSIUM (Aidarex Pharmaceuticals LLC), LOSORTAN POTASSIUM (American Health Packaging), LOSARTAN POTASSIUM (Apotex Corp), LOSARTAN POTASSIUM (Aurobindo Pharma Limited), LOSARTAN POTASSIUM (AvPAK), LOSORTAN POTASSIUM (Bryant Ranch Prepack), LOSARTAN POTASSIUM (Bryant Ranch Prepack), LOSORTAN POTASSIUM (Bryant Ranch Prepack), LOSARTAN POTASSIUM (Cadila Healthcare Limited), LOSORTAN POTASSIUM (Cardinal Health), LOSARTAN POTASSIUM (Cardinal Health), LOSARTAN POTASSIUM (Clinical Solutions Wholesale), LOSARTAN POTASSIUM (Clinical Solutions Wholesale), LOSARTAN POTASSIUM (Dispensing Solutions), LOSARTAN POTASSIUM (Endo Pharmaceuticals Inc. DBA Endo Generic Products), LOSARTAN POTASSIUM (Golden State Medical Supply), LOSARTAN POTASSIUM (Jubilant Cadista Pharmaceuticals), LOSORTAN POTASSIUM (Lake Erie Medical DBA Quality Care Products LLC), LOSARTAN POTASSIUM (Lake Erie Medical DBA Quality Care Products LLC), LOSARTAN POTASSIUM (Legacy Pharmaceutical Packaging), LOSARTAN POTASSIUM (Legacy Pharmaceutical Packaging), LOSARTAN POTASSIUM (Life Line Home Care Services), LOSARTAN POTASSIUM (Lupin Pharmaceuticals), LOSARTAN POTASSIUM (Macleods Pharmaceuticals Limited), LOSARTAN POTASSIUM (Major Pharmaceuticals), LOSARTAN POTASSIUM (McKesson Contract Packaging), LOSARTAN POTASSIUM (McKesson Packaging Services a business unit of McKesson Corporation), LOSARTAN POTASSIUM (MedVantx), LOSARTAN POTASSIUM (MedVantx), LOSARTAN POTASSIUM (Micro Labs Limited), LOSARTAN POTASSIUM (Mylan Pharmaceuticals), LOSARTAN POTASSIUM (NCS HealthCare of KY), LOSARTAN POTASSIUM (NorthStar Rx LLC), LOSARTAN POTASSIUM (PD-Rx Pharmaceuticals), LOSORTAN POTASSIUM (PD-Rx Pharmaceuticals), LOSARTAN POTASSIUM (PD-Rx Pharmaceuticals), LOSARTAN POTASSIUM (PD-Rx Pharmaceuticals), LOSARTAN POTASSIUM (Pack Pharmaceuticals), LOSARTAN POTASSIUM (Physicians Total Care), LOSARTAN POTASSIUM (Preferred Pharmaceuticals), LOSARTAN POTASSIUM (Preferred Pharmaceuticals), LOSARTAN POTASSIUM (Preferred Pharmaceuticals), LOSORTAN POTASSIUM (Proficient Rx LP), LOSARTAN POTASSIUM (Qualitest Pharmaceuticals), LOSARTAN POTASSIUM (REMEDYREPACK), LOSARTAN POTASSIUM (REMEDYREPACK), LOSARTAN POTASSIUM (REMEDYREPACK), LOSARTAN POTASSIUM (REMEDYREPACK), LOSARTAN POTASSIUM (REMEDYREPACK), LOSARTAN POTASSIUM (REMEDYREPACK), LOSORTAN POTASSIUM (REMEDYREPACK), LOSORTAN POTASSIUM (REMEDYREPACK), LOSARTAN POTASSIUM (REMEDYREPACK), LOSARTAN POTASSIUM (REMEDYREPACK), LOSARTAN POTASSIUM (REMEDYREPACK), LOSORTAN POTASSIUM (Rebel Distributors Corp), LOSORTAN POTASSIUM (Rebel Distributors Corp), LOSARTAN POTASSIUM (Roxane Laboratories), LOSARTAN POTASSIUM (STAT Rx USA LLC), LOSARTAN POTASSIUM (Sandoz), LOSARTAN POTASSIUM (St Marys Medical Park Pharmacy), LOSARTAN POTASSIUM (St Marys Medical Park Pharmacy), LOSARTAN POTASSIUM (State of Florida DOH Central Pharmacy), LOSARTAN POTASSIUM (Teva Pharmaceuticals USA), LOSARTAN POTASSIUM (Torrent Pharmaceuticals Limited), LOSARTAN POTASSIUM (Unit Dose Services), LOSARTAN POTASSIUM (Unit Dose Services), LOSARTAN POTASSIUM (Unit Dose Services), LOSARTAN POTASSIUM (Virtus Pharmaceuticals LLC), LOSARTAN POTASSIUM (Watson Laboratories), LOSORTAN POTASSIUM (Zydus Pharmaceuticals (USA)), LOSARTAN POTATSSIUM (New Horizon Rx Group)
Formula
C22H22ClN6O. K
Exact mass
460.1181
Mol weight
461.001
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Antihypertensive
Remark
Therapeutic category: 
ATC code: 
Drug group: 
Target
angiotensin II receptor type 1 (AT1) antagonist [HSA:185] [KO:K04166]
  Pathway
hsa04020  Calcium signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04270  Vascular smooth muscle contraction
hsa04614  Renin-angiotensin system  
 
Metabolism
Enzyme: CYP2C9 [HSA:1559], CYP3A4 [HSA:1576]
Interaction
Transporter inhibition: URAT1 [HSA:116085], ABCB11 (BSEP) [HSA:8647]
Drug interaction
Structure map
Angiotensin receptor and endothelin receptor antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 C CARDIOVASCULAR SYSTEM
  C09 AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM
   C09C ANGIOTENSIN II ANTAGONISTS, PLAIN
    C09CA Angiotensin II antagonists, plain
     C09CA01 Losartan
      D00357  Losartan potassium (JP16/USAN)
USP drug classification [BR:br08302]
 Cardiovascular Agents
  Angiotensin II Receptor Antagonists
   Losartan
    D00357  Losartan potassium (JP16/USAN)
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  21  Cardiovascular agents
   214  Antihypertensives
    2149  Others
     D00357  Losartan potassium (JP16/USAN)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Angiotensin
    angiotensin II stimulates angiotensin subtype 1 (AT1) receptor
     Losartan
      D00357  Losartan potassium (JP16/USAN)
Cytochrome P450 interactions [BR:br08309]
 Substrates
  CYP2C9
   Losartan
    D00357  Losartan potassium (JP16/USAN)
  CYP3A4
   Losartan
    D00357  Losartan potassium (JP16/USAN)
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D00357  Losartan potassium
  D00357  Losartan potassium tablets
BRITE hierarchy
Other DBs
CAS: 
124750-99-8
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        31
            1   N4y N    22.4920  -11.1792
            2   C8y C    22.9128  -12.4884
            3   C8y C    23.6142  -10.3376
            4   C1b C    21.2763  -10.4778
            5   N5x N    24.3155  -12.4884
            6   C1b C    22.0712  -13.6573
            7   C8y C    24.7363  -11.1792
            8   C1b C    23.6142   -8.9349
            9   C8y C    20.0607  -11.2260
            10  C1b C    22.6790  -14.9197
            11  X   Cl   26.0922  -10.7584
            12  O1a O    24.8298   -8.2335
            13  C8x C    20.0607  -12.6286
            14  C8x C    18.8451  -10.5246
            15  C1b C    21.8374  -16.0418
            16  C8x C    18.8917  -13.3300
            17  C8x C    17.6761  -11.3194
            18  C1a C    22.3984  -17.3509
            19  C8y C    17.6761  -12.6754
            20  C8y C    16.4605  -13.3768
            21  C8y C    15.2448  -12.6754
            22  C8x C    16.4605  -14.7794
            23  C8y C    15.2448  -11.2727
            24  C8x C    14.0292  -13.4235
            25  C8x C    15.2916  -15.4808
            26  N4x N    14.1226  -10.4778 #-
            27  N5x N    16.3669  -10.4311
            28  C8x C    14.0292  -14.8729
            29  N5x N    14.5435   -9.1219
            30  N5x N    15.8994   -9.1219
            31  Z   K    11.0368  -10.5714 #+
BOND        33
            1     1   2 1
            2     1   3 1
            3     1   4 1
            4     2   5 2
            5     2   6 1
            6     3   7 2
            7     3   8 1
            8     4   9 1
            9     6  10 1
            10    7  11 1
            11    8  12 1
            12    9  13 2
            13    9  14 1
            14   10  15 1
            15   13  16 1
            16   14  17 2
            17   15  18 1
            18   16  19 2
            19   19  20 1
            20   20  21 1
            21   20  22 2
            22   21  23 1
            23   21  24 2
            24   22  25 1
            25   23  26 1
            26   23  27 2
            27   24  28 1
            28   26  29 1
            29   27  30 1
            30    5   7 1
            31   17  19 1
            32   25  28 2
            33   29  30 2

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