KEGG   DRUG: LidocaineHelp
Entry
D00358                      Drug                                   

Name
Lidocaine (JP17/USP/INN);
Dentipatch (TN);
Xylocaine (TN)
Product
  Generic
LIDOCAINE (Actavis Pharma), LIDOCAINE (Aidarex Pharmaceuticals LLC), LIDOCAINE (Aidarex Pharmaceuticals LLC), LIDOCAINE (Amneal Pharmaceuticals LLC), LIDOCAINE (Amneal Pharmaceuticals LLC), LIDOCAINE (Ascend Laboratories), LIDOCAINE (AvKARE), LIDOCAINE (Cardinal Health), LIDOCAINE (Cardinal Health), LIDOCAINE (E. Fougera & Co. a division of Fougera Pharmaceuticals), LIDOCAINE (GSMS), LIDOCAINE (Gemini Laboratories), LIDOCAINE (Glenmark Pharmaceuticals), LIDOCAINE (Hi-Tech Pharmacal), LIDOCAINE (IPG PHARMACEUTICALS), LIDOCAINE (IPG Pharmaceuticals), LIDOCAINE (Ingenus Pharmaceuticals), LIDOCAINE (Lake Erie Medical DBA Quality Care Products LLC), LIDOCAINE (Lake Erie Medical DBA Quality Care Products LLC), LIDOCAINE (Lake Erie Medical DBA Quality Care Products LLC), LIDOCAINE (Lake Erie Medical DBA Quality Care Products LLC), LIDOCAINE (Lake Erie Medical DBA Quality Care Products LLC), LIDOCAINE (Liberty Pharmaceuticals), LIDOCAINE (Mylan Pharmaceuticals), LIDOCAINE (Novocol), LIDOCAINE (Par Pharmaceutical), LIDOCAINE (Pharmaceutica North America), LIDOCAINE (Pharmaceutica North America), LIDOCAINE (Preferred Pharmaceuticals), LIDOCAINE (Preferred Pharmaceuticals), LIDOCAINE (Preferred Pharmaceuticals), LIDOCAINE (Preferred Pharmaceuticals), LIDOCAINE (Preferred Pharmaceuticals), LIDOCAINE (Preferred Pharmaceuticals), LIDOCAINE (Proficient Rx LP), LIDOCAINE (Proficient Rx LP), LIDOCAINE (Proficient Rx LP), LIDOCAINE (PureTek Corporation), LIDOCAINE (REMEDYREPACK), LIDOCAINE (REMEDYREPACK), LIDOCAINE (REMEDYREPACK), LIDOCAINE (Rebel Distributors Corp), LIDOCAINE (Septodont), LIDOPAC (Sterling-Knight Pharmaceuticals), LIDOCAINE (Sterling-Knight Pharmaceuticals), LIDOCAINE (Taro Pharmaceuticals U.S.A.), LIDOCAINE (Taro Pharmaceuticals U.S.A.), LIDOCAINE (Teligent Pharma), LIDOCAINE (Unit Dose Services), LIDOCAINE (Unit Dose Services), LIDOCAINE (VITRUVIAS THERAPEUTICS), LIDOCAINE 5% (KBS Solutions)
  Other
Formula
C14H22N2O
Exact mass
234.1732
Mol weight
234.3373
Structure
Mol fileKCF fileDB searchJmolKegDraw
Simcomp SIMCOMP
Class
Cardiovascular agent
 DG01653  Antiarrhythmics
  DG01652  Class I antiarrhythmic agent
   DG01651  Class Ib antiarrhythmic agent
Neuropsychiatric agent
 DG02030  Anesthetics
  DG01675  Local anesthetic
   DG01673  Amide type local anesthetic
 DG01675  Local anesthetic
  DG01673  Amide type local anesthetic
Cyp substrate
 DG01892  CYP1A2 substrate
 DG01644  CYP2D6 substrate
 DG01633  CYP3A substrate
Remark
Same as: C07073
Therapeutic category: 1214
ATC code: C01BB01 C05AD01 D04AB01 N01BB02 R02AD02 S01HA07 S02DA01
Chemical structure group: DG00196
Product (DG00196): D00358<JP/US> D02086<JP/US> D08127<JP>
Product (mixture): D02740<JP/US> D04881<JP> D04692<JP> D04688<JP> D07742<JP>
Efficacy
Anesthetic (topical), Antiarrhythmic, Sodium channel blocker
Comment
Anilide derivative
Target
SCN1A [HSA:6323] [KO:K04833]
SCN2A [HSA:6326] [KO:K04834]
SCN3A [HSA:6328] [KO:K04836]
SCN4A [HSA:6329] [KO:K04837]
SCN5A [HSA:6331] [KO:K04838]
SCN8A [HSA:6334] [KO:K04840]
SCN9A [HSA:6335] [KO:K04841]
SCN10A [HSA:6336] [KO:K04842]
SCN11A [HSA:11280] [KO:K04843]
  Pathway
hsa04261  Adrenergic signaling in cardiomyocytes
hsa04728  Dopaminergic synapse
Metabolism
Enzyme: CYP1A2 [HSA:1544], CYP3A4 [HSA:1576]
Interaction
Drug interaction
Structure map
map07037  Antiarrhythmic drugs
map07231  Sodium channel blocking drugs
Other map
map00982  Drug metabolism - cytochrome P450
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 C CARDIOVASCULAR SYSTEM
  C01 CARDIAC THERAPY
   C01B ANTIARRHYTHMICS, CLASS I AND III
    C01BB Antiarrhythmics, class Ib
     C01BB01 Lidocaine
      D00358  Lidocaine (JP17/USP/INN)
  C05 VASOPROTECTIVES
   C05A AGENTS FOR TREATMENT OF HEMORRHOIDS AND ANAL FISSURES FOR TOPICAL USE
    C05AD Local anesthetics
     C05AD01 Lidocaine
      D00358  Lidocaine (JP17/USP/INN)
 D DERMATOLOGICALS
  D04 ANTIPRURITICS, INCL. ANTIHISTAMINES, ANESTHETICS, ETC.
   D04A ANTIPRURITICS, INCL. ANTIHISTAMINES, ANESTHETICS, ETC.
    D04AB Anesthetics for topical use
     D04AB01 Lidocaine
      D00358  Lidocaine (JP17/USP/INN)
 N NERVOUS SYSTEM
  N01 ANESTHETICS
   N01B ANESTHETICS, LOCAL
    N01BB Amides
     N01BB02 Lidocaine
      D00358  Lidocaine (JP17/USP/INN)
 R RESPIRATORY SYSTEM
  R02 THROAT PREPARATIONS
   R02A THROAT PREPARATIONS
    R02AD Anesthetics, local
     R02AD02 Lidocaine
      D00358  Lidocaine (JP17/USP/INN)
 S SENSORY ORGANS
  S01 OPHTHALMOLOGICALS
   S01H LOCAL ANESTHETICS
    S01HA Local anesthetics
     S01HA07 Lidocaine
      D00358  Lidocaine (JP17/USP/INN)
  S02 OTOLOGICALS
   S02D OTHER OTOLOGICALS
    S02DA Analgesics and anesthetics
     S02DA01 Lidocaine
      D00358  Lidocaine (JP17/USP/INN)
USP drug classification [BR:br08302]
 Anesthetics
  Local Anesthetics
   Lidocaine
    D00358  Lidocaine (JP17/USP/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  12  Agents affecting peripheral nervous system
   121  Local anesthetics
    1214  Xylidines
     D00358  Lidocaine (JP17/USP/INN)
Classification of Japanese OTC drugs [BR:br08313]
 Agents for  urogenital organs and anus
  30 Hemorrhoid drugs for external use
   D00358  Lidocaine (JP17/USP/INN)
 Agents for integumentary system
  57 Analgesic, antipruritic, astringent, and anti-inflammatory remedies (incl. gel patches)
   D00358  Lidocaine (JP17/USP/INN)
Risk category of Japanese OTC drugs [BR:br08312]
 Second-class OTC drugs
  Inorganic and organic chemicals
   Lidocaine
    D00358  Lidocaine (JP17/USP/INN)
Pharmaceutical additives in Japan [BR:br08316]
 Soothing agent
  D00358  [001667] Lidocaine
 Solubilizer
  D00358  [001667] Lidocaine
 Solubilization agent
  D00358  [001667] Lidocaine
 Solvent
  D00358  [001667] Lidocaine
Target-based classification of drugs [BR:br08310]
 Ion channels
  Voltage-gated cation channels
   Na+ channel, SCN alpha, NaV1.x
    voltage-gated sodium channel (SCN1A)
     Lidocaine
      D00358  Lidocaine (JP17/USP/INN)
    voltage-gated sodium channel (SCN2A)
     Lidocaine
      D00358  Lidocaine (JP17/USP/INN)
    voltage-gated sodium channel (SCN3A)
     Lidocaine
      D00358  Lidocaine (JP17/USP/INN)
    voltage-gated sodium channel (SCN4A)
     Lidocaine
      D00358  Lidocaine (JP17/USP/INN)
    voltage-gated sodium channel (SCN5A)
     Lidocaine
      D00358  Lidocaine (JP17/USP/INN)
    voltage-gated sodium channel (SCN8A)
     Lidocaine
      D00358  Lidocaine (JP17/USP/INN)
    voltage-gated sodium channel (SCN9A)
     Lidocaine
      D00358  Lidocaine (JP17/USP/INN)
    voltage-gated sodium channel (SCN10A)
     Lidocaine
      D00358  Lidocaine (JP17/USP/INN)
    voltage-gated sodium channel (SCN11A)
     Lidocaine
      D00358  Lidocaine (JP17/USP/INN)
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D00358  Lidocaine
  D00358  Lidocaine injection
Drug classes of therapeutic agents [br08360.html]
 Anesthetics, analgesics and anti-inflammatory drugs
  D00358
BRITE hierarchy
Other DBs
CAS: 137-58-6
PubChem: 7847424
ChEBI: 6456
ChEMBL: CHEMBL79
DrugBank: DB00281
PDB-CCD: LQZ[PDBj]
LigandBox: D00358
NIKKAJI: J5.631F
KCF data Show

ATOM        17
            1   C8y C    23.2602  -19.0646
            2   N1b N    24.4935  -19.7778
            3   C8y C    22.0325  -19.7836
            4   C8y C    23.2602  -17.6441
            5   C5a C    25.7213  -19.0587
            6   C8x C    20.8049  -19.0646
            7   C1a C    22.0384  -21.1983
            8   C8x C    22.0325  -16.9367
            9   C1a C    24.4818  -16.9367
            10  C1b C    26.9488  -19.7778
            11  O5a O    25.7096  -17.6332
            12  C8x C    20.8049  -17.6441
            13  N1c N    28.1823  -19.0587
            14  C1b C    29.4158  -19.7778
            15  C1b C    28.1823  -17.6441
            16  C1a C    30.6317  -19.0587
            17  C1a C    29.4158  -16.9309
BOND        17
            1     1   2 1
            2     1   3 2
            3     1   4 1
            4     2   5 1
            5     3   6 1
            6     3   7 1
            7     4   8 2
            8     4   9 1
            9     5  10 1
            10    5  11 2
            11    6  12 2
            12   10  13 1
            13   13  14 1
            14   13  15 1
            15   14  16 1
            16   15  17 1
            17    8  12 1

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