KEGG   DRUG: LidocaineHelp
Entry
D00358                      Drug                                   

Name
Lidocaine (JP17/USP/INN);
Dentipatch (TN);
Xylocaine (TN)
Product
  Generic
LIDOCAINE (Actavis Pharma), LIDOCAINE (Actavis Pharma), LIDOCAINE (Aidarex Pharmaceuticals LLC), LIDOCAINE (Amneal Pharmaceuticals of New York), LIDOCAINE (AvKARE), LIDOCAINE (Bryant Ranch Prepack), LIDOCAINE (Cardinal Health), LIDOCAINE (Clinical Solutions Wholesale), LIDOCAINE (DIRECT RX), LIDOCAINE (E. Fougera & Co. a division of Fougera Pharmaceuticals), LIDOCAINE (Gemini Laboratories), LIDOCAINE (Hi-Tech Pharmacal), LIDOCAINE (Lake Erie Medical DBA Quality Care Products LLC), LIDOCAINE (Mylan Pharmaceuticals), LIDOCAINE (Novocol), LIDOCAINE (Pharmaceutica North America), LIDOCAINE (Pharmaceutica North America), LIDOCAINE (Preferred Pharmaceuticals), LIDOCAINE (Preferred Pharmaceuticals), LIDOCAINE (Preferred Pharmaceuticals), LIDOCAINE (PureTek Corporation), LIDOCAINE (Qualitest Pharmaceuticals), LIDOCAINE (Rebel Distributors Corp), LIDOCAINE (Septodont), LIDOCAINE (Taro Pharmaceuticals U.S.A.), LIDOCAINE (Taro Pharmaceuticals U.S.A.), LIDOCAINE (Teligent Pharma), LIDOCAINE (Unit Dose Services), LIDOCAINE HYDROCHLORIDE (Unit Dose Services), LIDOCAINE (Solubiomix)
  Other
Formula
C14H22N2O
Exact mass
234.1732
Mol weight
234.3373
Structure
Mol fileKCF fileDB searchJmolKegDraw
Class
Cardiovascular agent
 DG01653  Antiarrhythmics
  DG01652  Class I antiarrhythmic agent
   DG01651  Class Ib antiarrhythmic agent
Neuropsychiatric agent
 DG01675  Local anesthetic
  DG01673  Amide type local anesthetic
Cyp substrate
 DG01892  CYP1A2 substrate
 DG01644  CYP2D6 substrate
 DG01633  CYP3A4 substrate
Remark
Same as: 
Therapeutic category: 
ATC code: 
Chemical group: 
Activity
Anesthetic (topical), Antiarrhythmic
Comment
Class I antiarrhythmic agent (Ib)
Target
voltage-gated sodium channel (SCN1A) [HSA:6323] [KO:K04833];
voltage-gated sodium channel (SCN2A) [HSA:6326] [KO:K04834];
voltage-gated sodium channel (SCN3A) [HSA:6328] [KO:K04836];
voltage-gated sodium channel (SCN4A) [HSA:6329] [KO:K04837];
voltage-gated sodium channel (SCN5A) [HSA:6331] [KO:K04838];
voltage-gated sodium channel (SCN8A) [HSA:6334] [KO:K04840];
voltage-gated sodium channel (SCN9A) [HSA:6335] [KO:K04841];
voltage-gated sodium channel (SCN10A) [HSA:6336] [KO:K04842]
Metabolism
Enzyme: CYP1A2 [HSA:1544], CYP3A4 [HSA:1576], CYP2D6 [HSA:1565]
Transporter: SLC22A3 [HSA:6581]
Interaction
Drug interaction
Structure map
Antiarrhythmic drugs
Sodium channel blocking drugs
Other map
Drug metabolism - cytochrome P450
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 C CARDIOVASCULAR SYSTEM
  C01 CARDIAC THERAPY
   C01B ANTIARRHYTHMICS, CLASS I AND III
    C01BB Antiarrhythmics, class Ib
     C01BB01 Lidocaine
      D00358  Lidocaine (JP17/USP/INN)
  C05 VASOPROTECTIVES
   C05A AGENTS FOR TREATMENT OF HEMORRHOIDS AND ANAL FISSURES FOR TOPICAL USE
    C05AD Local anesthetics
     C05AD01 Lidocaine
      D00358  Lidocaine (JP17/USP/INN)
 D DERMATOLOGICALS
  D04 ANTIPRURITICS, INCL. ANTIHISTAMINES, ANESTHETICS, ETC.
   D04A ANTIPRURITICS, INCL. ANTIHISTAMINES, ANESTHETICS, ETC.
    D04AB Anesthetics for topical use
     D04AB01 Lidocaine
      D00358  Lidocaine (JP17/USP/INN)
 N NERVOUS SYSTEM
  N01 ANESTHETICS
   N01B ANESTHETICS, LOCAL
    N01BB Amides
     N01BB02 Lidocaine
      D00358  Lidocaine (JP17/USP/INN)
 R RESPIRATORY SYSTEM
  R02 THROAT PREPARATIONS
   R02A THROAT PREPARATIONS
    R02AD Anesthetics, local
     R02AD02 Lidocaine
      D00358  Lidocaine (JP17/USP/INN)
 S SENSORY ORGANS
  S01 OPHTHALMOLOGICALS
   S01H LOCAL ANESTHETICS
    S01HA Local anesthetics
     S01HA07 Lidocaine
      D00358  Lidocaine (JP17/USP/INN)
  S02 OTOLOGICALS
   S02D OTHER OTOLOGICALS
    S02DA Analgesics and anesthetics
     S02DA01 Lidocaine
      D00358  Lidocaine (JP17/USP/INN)
USP drug classification [BR:br08302]
 Anesthetics
  Local Anesthetics
   Lidocaine
    D00358  Lidocaine (JP17/USP/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  12  Agents affecting peripheral nervous system
   121  Local anesthetics
    1214  Xylidines
     D00358  Lidocaine (JP17/USP/INN)
Classification of Japanese OTC drugs [BR:br08313]
 Agents for  urogenital organs and anus
  30 Hemorrhoid drugs for external use
   D00358  Lidocaine (JP17/USP/INN)
 Agents for integumentary system
  57 Analgesic, antipruritic, astringent, and anti-inflammatory remedies (incl. gel patches)
   D00358  Lidocaine (JP17/USP/INN)
Risk category of Japanese OTC drugs [BR:br08312]
 Second-class OTC drugs
  Inorganic and organic chemicals
   Lidocaine
    D00358  Lidocaine (JP17/USP/INN)
Pharmaceutical additives [BR:br08316]
 Soothing agent
  D00358  [001667] Lidocaine
 Solubilizer
  D00358  [001667] Lidocaine
 Solubilization agent
  D00358  [001667] Lidocaine
 Solvent
  D00358  [001667] Lidocaine
Target-based classification of drugs [BR:br08310]
 Ion channels
  Voltage-gated cation channels
   Na+ channel, SCN alpha, NaV1.x
    voltage-gated sodium channel (SCN1A)
     Lidocaine
      D00358  Lidocaine (JP17/USP/INN)
    voltage-gated sodium channel (SCN2A)
     Lidocaine
      D00358  Lidocaine (JP17/USP/INN)
    voltage-gated sodium channel (SCN3A)
     Lidocaine
      D00358  Lidocaine (JP17/USP/INN)
    voltage-gated sodium channel (SCN4A)
     Lidocaine
      D00358  Lidocaine (JP17/USP/INN)
    voltage-gated sodium channel (SCN5A)
     Lidocaine
      D00358  Lidocaine (JP17/USP/INN)
    voltage-gated sodium channel (SCN8A)
     Lidocaine
      D00358  Lidocaine (JP17/USP/INN)
    voltage-gated sodium channel (SCN9A)
     Lidocaine
      D00358  Lidocaine (JP17/USP/INN)
    voltage-gated sodium channel (SCN10A)
     Lidocaine
      D00358  Lidocaine (JP17/USP/INN)
Cytochrome P450 interactions [BR:br08309]
 CYP substrates
  CYP1A2
   Lidocaine
    D00358  Lidocaine (JP17/USP/INN)
  CYP2D6
   Lidocaine
    D00358  Lidocaine (JP17/USP/INN)
  CYP3A4
   Lidocaine
    D00358  Lidocaine (JP17/USP/INN)
 Transporter substrates
  SLC22A3
   Lidocaine
    D00358  Lidocaine (JP17/USP/INN)
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D00358  Lidocaine
  D00358  Lidocaine injection
Anesthetics and analgesics [br08369.html]
 Anesthetics
  D00358
Orphan drugs in the USA [br08355.html]
 Orphan drugs in the USA
  D00358
BRITE hierarchy
Other DBs
CAS: 
137-58-6
PubChem: 
DrugBank: 
PDB-CCD: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        17
            1   C8y C    23.2602  -19.0646
            2   N1b N    24.4935  -19.7778
            3   C8y C    22.0325  -19.7836
            4   C8y C    23.2602  -17.6441
            5   C5a C    25.7213  -19.0587
            6   C8x C    20.8049  -19.0646
            7   C1a C    22.0384  -21.1983
            8   C8x C    22.0325  -16.9367
            9   C1a C    24.4818  -16.9367
            10  C1b C    26.9488  -19.7778
            11  O5a O    25.7096  -17.6332
            12  C8x C    20.8049  -17.6441
            13  N1c N    28.1823  -19.0587
            14  C1b C    29.4158  -19.7778
            15  C1b C    28.1823  -17.6441
            16  C1a C    30.6317  -19.0587
            17  C1a C    29.4158  -16.9309
BOND        17
            1     1   2 1
            2     1   3 2
            3     1   4 1
            4     2   5 1
            5     3   6 1
            6     3   7 1
            7     4   8 2
            8     4   9 1
            9     5  10 1
            10    5  11 2
            11    6  12 2
            12   10  13 1
            13   13  14 1
            14   13  15 1
            15   14  16 1
            16   15  17 1
            17    8  12 1

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