KEGG   DRUG: D00358Help
Entry
D00358                      Drug                                   

Name
Lidocaine (JP16/USP/INN);
Dentipatch (TN);
Xylocaine (TN)
Product
  Generic
  Other
Formula
C14H22N2O
Exact mass
234.1732
Mol weight
234.3373
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Anesthetic [topical]
Remark
Same as: 
Therapeutic category: 
ATC code: 
Drug group: 
Comment
Class I antiarrhythmic agent (Ib)
Target
voltage-gated sodium channel (SCN1A) blocker [HSA:6323] [KO:K04833];
voltage-gated sodium channel (SCN2A) blocker [HSA:6326] [KO:K04834];
voltage-gated sodium channel (SCN3A) blocker [HSA:6328] [KO:K04836];
voltage-gated sodium channel (SCN4A) blocker [HSA:6329] [KO:K04837];
voltage-gated sodium channel (SCN5A) blocker [HSA:6331] [KO:K04838];
voltage-gated sodium channel (SCN8A) blocker [HSA:6334] [KO:K04840];
voltage-gated sodium channel (SCN9A) blocker [HSA:6335] [KO:K04841];
voltage-gated sodium channel (SCN10A) blocker [HSA:6336] [KO:K04842]
Metabolism
Enzyme: CYP1A2 [HSA:1544], CYP3A4 [HSA:1576], CYP2D6 [HSA:1565]
Transporter: SLC22A3 [HSA:6581]
Interaction
Drug interaction
Structure map
Antiarrhythmic drugs
Sodium channel blocking drugs
Other map
Drug metabolism - cytochrome P450
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 C CARDIOVASCULAR SYSTEM
  C01 CARDIAC THERAPY
   C01B ANTIARRHYTHMICS, CLASS I AND III
    C01BB Antiarrhythmics, class Ib
     C01BB01 Lidocaine
      D00358  Lidocaine (JP16/USP/INN)
  C05 VASOPROTECTIVES
   C05A AGENTS FOR TREATMENT OF HEMORRHOIDS AND ANAL FISSURES FOR TOPICAL USE
    C05AD Local anesthetics
     C05AD01 Lidocaine
      D00358  Lidocaine (JP16/USP/INN)
 D DERMATOLOGICALS
  D04 ANTIPRURITICS, INCL. ANTIHISTAMINES, ANESTHETICS, ETC.
   D04A ANTIPRURITICS, INCL. ANTIHISTAMINES, ANESTHETICS, ETC.
    D04AB Anesthetics for topical use
     D04AB01 Lidocaine
      D00358  Lidocaine (JP16/USP/INN)
 N NERVOUS SYSTEM
  N01 ANESTHETICS
   N01B ANESTHETICS, LOCAL
    N01BB Amides
     N01BB02 Lidocaine
      D00358  Lidocaine (JP16/USP/INN)
 R RESPIRATORY SYSTEM
  R02 THROAT PREPARATIONS
   R02A THROAT PREPARATIONS
    R02AD Anesthetics, local
     R02AD02 Lidocaine
      D00358  Lidocaine (JP16/USP/INN)
 S SENSORY ORGANS
  S01 OPHTHALMOLOGICALS
   S01H LOCAL ANESTHETICS
    S01HA Local anesthetics
     S01HA07 Lidocaine
      D00358  Lidocaine (JP16/USP/INN)
  S02 OTOLOGICALS
   S02D OTHER OTOLOGICALS
    S02DA Analgesics and anesthetics
     S02DA01 Lidocaine
      D00358  Lidocaine (JP16/USP/INN)
USP drug classification [BR:br08302]
 Anesthetics
  Local Anesthetics
   Lidocaine
    D00358  Lidocaine (JP16/USP/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  12  Agents affecting peripheral nervous system
   121  Local anesthetics
    1214  Xylidines
     D00358  Lidocaine (JP16/USP/INN)
Classification of Japanese OTC drugs [BR:br08313]
 Agents for  urogenital organs and anus
  30 Hemorrhoid drugs for external use
   D00358  Lidocaine (JP16/USP/INN)
  -- Suppository for hemorrhoid
   D00358  Lidocaine (JP16/USP/INN)
  -- Hemorrhoid oinments
   D00358  Lidocaine (JP16/USP/INN)
 Agents for integumentary system
  57 Analgesic, antipruritic, astringent, and anti-inflammatory remedies (incl. gel patches)
   D00358  Lidocaine (JP16/USP/INN)
  -- Eczematous and dermatitis remedies
   D00358  Lidocaine (JP16/USP/INN)
  -- Antipruritic and insect sting remedies
   D00358  Lidocaine (JP16/USP/INN)
Risk category of Japanese OTC drugs [BR:br08312]
 Category 2
  Inorganic and organic chemicals
   Lidocaine
    D00358  Lidocaine (JP16/USP/INN)
Pharmaceutical additives [BR:br08316]
 Soothing agent
  D00358  [001667] Lidocaine
 Solubilizer
  D00358  [001667] Lidocaine
 Solubilization agent
  D00358  [001667] Lidocaine
 Solvent
  D00358  [001667] Lidocaine
Target-based classification of drugs [BR:br08310]
 Ion channels
  Voltage-gated cation channels
   Na+ channel, SCN alpha, NaV1.x
    voltage-gated sodium channel (SCN1A)
     Lidocaine
      D00358  Lidocaine (JP16/USP/INN)
    voltage-gated sodium channel (SCN2A)
     Lidocaine
      D00358  Lidocaine (JP16/USP/INN)
    voltage-gated sodium channel (SCN3A)
     Lidocaine
      D00358  Lidocaine (JP16/USP/INN)
    voltage-gated sodium channel (SCN4A)
     Lidocaine
      D00358  Lidocaine (JP16/USP/INN)
    voltage-gated sodium channel (SCN5A)
     Lidocaine
      D00358  Lidocaine (JP16/USP/INN)
    voltage-gated sodium channel (SCN8A)
     Lidocaine
      D00358  Lidocaine (JP16/USP/INN)
    voltage-gated sodium channel (SCN9A)
     Lidocaine
      D00358  Lidocaine (JP16/USP/INN)
    voltage-gated sodium channel (SCN10A)
     Lidocaine
      D00358  Lidocaine (JP16/USP/INN)
Cytochrome P450 interactions [BR:br08309]
 Substrates
  CYP1A2
   Lidocaine
    D00358  Lidocaine (JP16/USP/INN)
  CYP2D6
   Lidocaine
    D00358  Lidocaine (JP16/USP/INN)
  CYP3A4
   Lidocaine
    D00358  Lidocaine (JP16/USP/INN)
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D00358  Lidocaine
  D00358  Lidocaine injection
BRITE hierarchy
Other DBs
CAS: 
137-58-6
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        17
            1   C8y C    23.2602  -19.0646
            2   N1b N    24.4935  -19.7778
            3   C8y C    22.0325  -19.7836
            4   C8y C    23.2602  -17.6441
            5   C5a C    25.7213  -19.0587
            6   C8x C    20.8049  -19.0646
            7   C1a C    22.0384  -21.1983
            8   C8x C    22.0325  -16.9367
            9   C1a C    24.4818  -16.9367
            10  C1b C    26.9488  -19.7778
            11  O5a O    25.7096  -17.6332
            12  C8x C    20.8049  -17.6441
            13  N1c N    28.1823  -19.0587
            14  C1b C    29.4158  -19.7778
            15  C1b C    28.1823  -17.6441
            16  C1a C    30.6317  -19.0587
            17  C1a C    29.4158  -16.9309
BOND        17
            1     1   2 1
            2     1   3 2
            3     1   4 1
            4     2   5 1
            5     3   6 1
            6     3   7 1
            7     4   8 2
            8     4   9 1
            9     5  10 1
            10    5  11 2
            11    6  12 2
            12   10  13 1
            13   13  14 1
            14   13  15 1
            15   14  16 1
            16   15  17 1
            17    8  12 1

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