KEGG   DRUG: D00359Help
Entry
D00359                      Drug                                   

Name
Lovastatin (USP/INN);
MK-803;
ML-530B;
Mevacor (TN)
Product
  Generic
LOVASTATIN (Actavis), LOVASTATIN (Aidarex Pharmaceuticals LLC), LOVASTATIN (American Health Packaging), LOVASTATIN (Aphena Pharma Solutions - Tennessee), LOVASTATIN (Aphena Pharma Solutions - Tennessee), LOVASTATIN (AvKARE), LOVASTATIN (AvPAK), LOVASTATIN (BluePoint Laboratories), LOVASTATIN (Bryant Ranch Prepack), LOVASTATIN (Cardinal Health), LOVASTATIN (Cardinal Health), LOVASTATIN (Carlsbad Technology), LOVASTATIN (Dispensing Solutions), LOVASTATIN (Eon Labs), LOVASTATIN (Golden State Medical Supply), LOVASTATIN (Golden State Medical Supply), LOVASTATIN (International Labs), LOVASTATIN (International Labs), LOVASTATIN (KAISER FOUNDATION HOSPITALS), LOVASTATIN (Lake Erie Medical DBA Quality Care Products LLC), LOVASTATIN (Lake Erie Medical DBA Quality Care Products LLC), LOVASTATIN (Lake Erie Medical DBA Quality Care Products LLC), LOVASTATIN (Lupin Pharmaceuticals), LOVASTATIN (McKesson Packaging Services Business Unit of McKesson Corporation), LOVASTATIN (Mutual Pharmaceutical Company), LOVASTATIN (Mylan Institutional), LOVASTATIN (Mylan Pharmaceuticals), LOVASTATIN (NCS HealthCare of KY), LOVASTATIN (NCS HealthCare of KY), LOVASTATIN (NCS HealthCare of KY), LOVASTATIN (NCS HealthCare of KY), LOVASTATIN (PD-Rx Pharmaceuticals), LOVASTATIN (PD-Rx Pharmaceuticals), LOVASTATIN (PD-Rx Pharmaceuticals), LOVASTATIN (Physicians Total Care), LOVASTATIN (Preferred Pharmaceuticals), LOVASTATIN (Preferred Pharmaceuticals), LOVASTATIN (Preferred Pharmaceuticals), LOVASTATIN (Preferred Pharmaceuticals), LOVASTATIN (Preferred Pharmaceuticals), LOVASTATIN (Proficient Rx LP), LOVASTATIN (REMEDYREPACK), LOVASTATIN (REMEDYREPACK), LOVASTATIN (REMEDYREPACK), LOVASTATIN (REMEDYREPACK), LOVASTATIN (REMEDYREPACK), LOVASTATIN (REMEDYREPACK), LOVASTATIN (REMEDYREPACK), LOVASTATIN (REMEDYREPACK), LOVASTATIN (REMEDYREPACK), LOVASTATIN (REMEDYREPACK), LOVASTATIN (REMEDYREPACK), LOVASTATIN (REMEDYREPACK), LOVASTATIN (REMEDYREPACK), LOVASTATIN (REMEDYREPACK), LOVASTATIN (REMEDYREPACK), LOVASTATIN (REMEDYREPACK), LOVASTATIN (REMEDYREPACK), LOVASTATIN (REMEDYREPACK), LOVASTATIN (REMEDYREPACK), LOVASTATIN (REMEDYREPACK), LOVASTATIN (REMEDYREPACK), LOVASTATIN (REMEDYREPACK), LOVASTATIN (Rebel Distributors Corp), LOVASTATIN (Rebel Distributors Corp), LOVASTATIN (STAT Rx USA LLC), LOVASTATIN (St Marys Medical Park Pharmacy), LOVASTATIN (St Marys Medical Park Pharmacy), LOVASTATIN (St Marys Medical Park Pharmacy), LOVASTATIN (Teva Pharmaceuticals USA), LOVASTATIN (Unit Dose Services), LOVASTATIN (Unit Dose Services), LOVASTATIN (Unit Dose Services)
Formula
C24H36O5
Exact mass
404.2563
Mol weight
404.5396
Structure
Mol fileKCF fileDB searchJmolKegDraw
Source
Monascus ruber [TAX:89489], Aspergillus terreus [TAX:33178]
Activity
Antihyperlipidemic;
Inhibitor [HMG-CoA reductase]
Remark
Same as: 
ATC code: 
Comment
prodrug
Target
hydroxymethylglutaryl coenzyme A (HMG-CoA) reductase inhibitor [HSA:3156] [KO:K00021]
  Pathway
hsa00900  Terpenoid backbone biosynthesis  
 
Metabolism
Enzyme: CYP3A4 [HSA:1576], CYP3A5 [HSA:1577], CYP3A7 [HSA:1551]
Transpoter: SLCO1B1 [HSA:10599], ABCG2 (BCRP) [HSA:9429]
Interaction
CYP inhibition: CYP2C9 [HSA:1559]
Drug interaction
Structure map
HMG-CoA reductase inhibitors
Other map
Bile secretion
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 C CARDIOVASCULAR SYSTEM
  C10 LIPID MODIFYING AGENTS
   C10A LIPID MODIFYING AGENTS, PLAIN
    C10AA HMG CoA reductase inhibitors
     C10AA02 Lovastatin
      D00359  Lovastatin (USP/INN)
USP drug classification [BR:br08302]
 Cardiovascular Agents
  Dyslipidemics, HMG CoA Reductase Inhibitors
   Lovastatin
    D00359  Lovastatin (USP/INN)
Target-based classification of drugs [BR:br08310]
 Enzymes
  Oxidoreductases
   hydroxymethylglutaryl coenzyme A (HMG-CoA) reductase
    Lovastatin
     D00359  Lovastatin (USP/INN)
Cytochrome P450 interactions [BR:br08309]
 Substrates
  CYP3A4
   Lovastatin
    D00359  Lovastatin (USP/INN)
  CYP3A5
   Lovastatin
    D00359  Lovastatin (USP/INN)
  CYP3A7
   Lovastatin
    D00359  Lovastatin (USP/INN)
 Inhbitors
  CYP2C9
   Lovastatin
    D00359  Lovastatin (USP/INN)
BRITE hierarchy
Other DBs
CAS: 
75330-75-5
PubChem: 
DrugBank: 
PDB-CCD: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        29
            1   C1y C    26.2681  -21.4649
            2   C1y C    25.0617  -20.7655
            3   C2y C    26.2624  -22.8577
            4   C1y C    27.4745  -20.7713
            5   O7a O    25.0617  -19.3726
            6   C1x C    23.8497  -21.4649
            7   C2x C    27.4628  -23.5627
            8   C2x C    25.0617  -23.5570
            9   C1b C    27.4803  -19.3785
            10  C1y C    28.6808  -21.4766
            11  C7a C    23.8555  -18.6733
            12  C1y C    23.8497  -22.8577
            13  C2x C    28.6750  -22.8694
            14  C1c C    22.6491  -19.3726
            15  O6a O    23.8613  -17.2805
            16  C1a C    22.6433  -23.5570
            17  C1b C    21.4427  -18.6733
            18  C1a C    22.6491  -20.7655
            19  C1a C    20.2364  -19.3669
            20  C1a C    29.8734  -20.7959
            21  C1b C    28.7139  -18.6619
            22  C1y C    28.7173  -17.2654
            23  O7x O    29.9266  -16.5712
            24  C7x C    29.9300  -15.1747
            25  C1x C    28.7223  -14.4735
            26  C1y C    27.5132  -15.1677
            27  C1x C    27.5097  -16.5641
            28  O6a O    31.1392  -14.4805
            29  O1a O    26.2978  -14.4619
BOND        31
            1     1   2 1
            2     1   3 1
            3     1   4 1
            4     2   5 1 #Down
            5     2   6 1
            6     3   7 1
            7     3   8 2
            8     4   9 1 #Up
            9     4  10 1
            10    5  11 1
            11    6  12 1
            12    7  13 2
            13   11  14 1
            14   11  15 2
            15   12  16 1 #Down
            16   14  17 1
            17   14  18 1 #Up
            18   17  19 1
            19    8  12 1
            20   10  13 1
            21   10  20 1 #Up
            22    9  21 1
            23   22  21 1 #Down
            24   22  23 1
            25   23  24 1
            26   24  25 1
            27   25  26 1
            28   26  27 1
            29   22  27 1
            30   24  28 2
            31   26  29 1 #Up

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