KEGG   DRUG: D00365Help
Entry
D00365                      Drug                                   

Name
Lorazepam (JP16/USP/INN);
Ativan (TN)
Product
  Generic
LORAZEPAM (A-S Medication Solutions LLC), LORAZEPAM (A-S Medication Solutions LLC), LORAZEPAM (Actavis Elizabeth LLC), LORAZEPAM (Aidarex Pharmaceuticals LLC), LORAZEPAM (Akorn), LORAZEPAM (American Health Packaging), LORAZEPAM (American Health Packaging), LORAZEPAM (American Health Packaging), LORAZEPAM (Amneal Pharmaceuticals), LORAZEPAM (Aphena Pharma Solutions - Tennessee), LORAZEPAM (Aphena Pharma Solutions - Tennessee), LORAZEPAM (Apotheca), LORAZEPAM (AvPAK), LORAZEPAM (Blenheim Pharmacal), LORAZEPAM (Bryant Ranch Prepack), LORAZEPAM (Bryant Ranch Prepack), LORAZEPAM (Cardinal Health), LORAZEPAM (Cardinal Health), LORAZEPAM (Cardinal Health), LORAZEPAM (Cardinal Health), LORAZEPAM (Cardinal Health), LORAZEPAM (Contract Pharmacy Services-PA), LORAZEPAM (Dispensing Solutions), LORAZEPAM (Dispensing Solutions), LORAZEPAM (Excellium Pharmaceutical), LORAZEPAM (Hi-Tech Pharmacal), LORAZEPAM (Hospira), LORAZEPAM (Hospira), LORAZEPAM (Hospira), LORAZEPAM (International Medication Systems), LORAZEPAM (KAISER FOUNDATION HOSPITALS), LORAZEPAM (KAISER FOUNDATION HOSPITALS), LORAZEPAM (KAISER FOUNDATION HOSPITALS), LORAZEPAM (Lake Erie Medical & Surgical Supply DBA Quality Care Products LLC), LORAZEPAM (Lake Erie Medical DBA Quality Care Products LLC), LORAZEPAM (Lake Erie Medical DBA Quality Care Products LLC), LORAZEPAM (Lake Erie Medical DBA Quality Care Products LLC), LORAZEPAM (Lake Erie Medical DBA Quality Care Products LLC), LORAZEPAM (Lake Erie Medical DBA Quality Care Products LLC), LORAZEPAM (Life Line Home Care Services), LORAZEPAM (Major Pharmaceuticals), LORAZEPAM (Major Pharmaceuticals), LORAZEPAM (McKesson Contract Packaging), LORAZEPAM (McKesson Packaging Services Business Unit of McKesson Corporation), LORAZEPAM (McKesson Packaging Services Business Unit of McKesson Corporation), LORAZEPAM (McKesson Packaging Services a business unit of McKesson Corporation), LORAZEPAM (Mylan Institutional), LORAZEPAM (Mylan Pharmaceuticals), LORAZEPAM (Northwind Pharmaceuticals), LORAZEPAM (PD-Rx Pharmaceuticals), LORAZEPAM (PD-Rx Pharmaceuticals), LORAZEPAM (PD-Rx Pharmaceuticals), LORAZEPAM (PD-Rx Pharmaceuticals), LORAZEPAM (PD-Rx Pharmaceuticals), LORAZEPAM (Paddock Laboratories), LORAZEPAM (Pharmaceutical Associates), LORAZEPAM (Physicians Total Care), LORAZEPAM (Physicians Total Care), LORAZEPAM (Physicians Total Care), LORAZEPAM (Preferred Pharmaceuticals), LORAZEPAM (Preferred Pharmaceuticals), LORAZEPAM (Preferred Pharmaceuticals), LORAZEPAM (Proficient Rx LP), LORAZEPAM (Qualitest Pharmaceuticals), LORAZEPAM (REMEDYREPACK), LORAZEPAM (REMEDYREPACK), LORAZEPAM (REMEDYREPACK), LORAZEPAM (REMEDYREPACK), LORAZEPAM (REMEDYREPACK), LORAZEPAM (REMEDYREPACK), LORAZEPAM (REMEDYREPACK), LORAZEPAM (REMEDYREPACK), LORAZEPAM (REMEDYREPACK), LORAZEPAM (REMEDYREPACK), LORAZEPAM (Ranbaxy Pharmaceuticals), LORAZEPAM (Rebel Distributors Corp), LORAZEPAM (Rebel Distributors Corp), LORAZEPAM (Rebel Distributors Corp), LORAZEPAM (RedPharm Drug), LORAZEPAM (RedPharm Drug), LORAZEPAM (RedPharm), LORAZEPAM (Roxane Laboratories), LORAZEPAM (Rx Pak Division of McKesson Corporation), LORAZEPAM (RxChange), LORAZEPAM (STAT RX USA LLC), LORAZEPAM (STAT Rx USA LLC), LORAZEPAM (Sandoz), LORAZEPAM (Sandoz), LORAZEPAM (TYA Pharmaceuticals), LORAZEPAM (TYA Pharmaceuticals), LORAZEPAM (Teva Pharmaceuticals USA), LORAZEPAM (Unit Dose Services), LORAZEPAM (Unit Dose Services), LORAZEPAM (Unit Dose Services), LORAZEPAM (Upsher-Smith Laboratories), LORAZEPAM (Watson Laboratories), LORAZEPAM (bryant ranch prepack)
Formula
C15H10Cl2N2O2
Exact mass
320.0119
Mol weight
321.1581
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Tranquilizer [minor]
Remark
Therapeutic category: 
ATC code: 
Drug group: 
Comment
Benzodiazepines
Target
GABAA-receptor (benzodiazepine binding site) agonist [HSA:2554 2555 2556 2557 2558 2559 2560 2561 2562 2563 2564 2565 2566 2567 2568 55879] [KO:K05175 K05181 K05184 K05185 K05186 K05189 K05192]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04727  GABAergic synapse  
 
Interaction
Drug interaction
Structure map
Anxiolytics
GABA-A receptor agonists/antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N05 PSYCHOLEPTICS
   N05B ANXIOLYTICS
    N05BA Benzodiazepine derivatives
     N05BA06 Lorazepam
      D00365  Lorazepam (JP16/USP/INN)
USP drug classification [BR:br08302]
 Anticonvulsants
  Gamma-aminobutyric Acid (GABA) Augmenting Agents
   Lorazepam
    D00365  Lorazepam (JP16/USP/INN)
 Anxiolytics
  Benzodiazepines
   Lorazepam
    D00365  Lorazepam (JP16/USP/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  11  Agents affecting central nervous system
   112  Hypnotics and sedatives, anxiolytics
    1124  Benzodiazepins
     D00365  Lorazepam (JP16/USP/INN)
Target-based classification of drugs [BR:br08310]
 Ion channels
  Cys-loop superfamily
   GABA-A
    GABAA-receptor (benzodiazepine binding site)
     Lorazepam
      D00365  Lorazepam (JP16/USP/INN)
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D00365  Lorazepam
BRITE hierarchy
Other DBs
CAS: 
846-49-1
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        21
            1   C2y C    19.5808  -11.8131
            2   C8y C    18.7361  -10.7001
            3   C8y C    19.0723   -9.3392
            4   N1x N    20.3372   -8.7593
            5   N2x N    20.9909  -11.8384
            6   C5x C    21.5946   -9.3835
            7   C1y C    21.8820  -10.7564
            8   C8x C    18.0621   -8.3678
            9   C8x C    16.7160   -8.7571
            10  C8y C    16.3798  -10.1180
            11  C8x C    17.3900  -11.0891
            12  O1a O    23.2172  -11.1948
            13  O5x O    22.6419   -8.4462
            14  X   Cl   15.0268  -10.5091
            15  C8y C    18.8591  -13.0128
            16  C8x C    17.4591  -13.0128
            17  C8x C    16.7591  -14.2252
            18  C8x C    17.4591  -15.4377
            19  C8x C    18.8591  -15.4377
            20  C8y C    19.5591  -14.2252
            21  X   Cl   20.9299  -14.2249
BOND        23
            1     3   4 1
            2     1   5 2
            3     4   6 1
            4     2   3 1
            5     5   7 1
            6     1   2 1
            7     6   7 1
            8     3   8 2
            9     8   9 1
            10    9  10 2
            11   10  11 1
            12    2  11 2
            13    7  12 1
            14    6  13 2
            15   10  14 1
            16    1  15 1
            17   15  16 1
            18   16  17 2
            19   17  18 1
            20   18  19 2
            21   19  20 1
            22   15  20 2
            23   20  21 1

» Japanese version   » Back

DBGET integrated database retrieval system