KEGG   DRUG: D00367Help
Entry
D00367                      Drug                                   

Name
Mazindol (JAN/USP/INN);
Sanorex (TN)
Formula
C16H13ClN2O
Exact mass
284.0716
Mol weight
284.7402
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Anorexic
Remark
Therapeutic category: 
ATC code: 
Target
noradrenalin transporter inhibitor [HSA:6530] [KO:K05035];
dopamine transporter inhibitor [HSA:6531] [KO:K05036];
serotonin transporter inhibitor [HSA:6532] [KO:K05037]
  Pathway
hsa04726  Serotonergic synapse
hsa04728  Dopaminergic synapse  
 
Interaction
Drug interaction
Structure map
Neurotransmitter transporter inhibitors
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 A ALIMENTARY TRACT AND METABOLISM
  A08 ANTIOBESITY PREPARATIONS, EXCL. DIET PRODUCTS
   A08A ANTIOBESITY PREPARATIONS, EXCL. DIET PRODUCTS
    A08AA Centrally acting antiobesity products
     A08AA05 Mazindol
      D00367  Mazindol (JAN/USP/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  11  Agents affecting central nervous system
   119  Miscellaneous
    1190  Miscellaneous
     D00367  Mazindol (JAN/USP/INN)
Target-based classification of drugs [BR:br08310]
 Transporters
  Solute carrier family
   SLC6
    SLC6A2 (noradrenalin transporter)
     Mazindol
      D00367  Mazindol (JAN/USP/INN)
    SLC6A3 (dopamine transporter)
     Mazindol
      D00367  Mazindol (JAN/USP/INN)
    SLC6A4 (serotonin transporter)
     Mazindol
      D00367  Mazindol (JAN/USP/INN)
BRITE hierarchy
Other DBs
CAS: 
22232-71-9
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        20
            1   C1z C    26.5010  -18.0774
            2   N1y N    27.3416  -16.9509
            3   C8y C    25.1586  -17.6397
            4   C8y C    26.5010  -19.4315
            5   O1a O    27.9369  -18.5735
            6   C2y C    26.5127  -15.7895
            7   C1x C    28.6957  -16.5132
            8   C8y C    25.1645  -16.2272
            9   C8x C    23.9329  -18.3342
            10  C8x C    25.3278  -20.0969
            11  C8x C    27.6742  -20.0969
            12  N2x N    27.3532  -14.6454
            13  C1x C    28.7014  -15.0890
            14  C8x C    23.9387  -15.5151
            15  C8x C    22.7188  -17.6280
            16  C8x C    25.3278  -21.4510
            17  C8x C    27.6742  -21.4510
            18  C8x C    22.7247  -16.2155
            19  C8y C    26.5010  -22.1280
            20  X   Cl   26.5010  -23.5346
BOND        23
            1     1   2 1
            2     1   3 1
            3     1   4 1
            4     1   5 1
            5     2   6 1
            6     2   7 1
            7     3   8 2
            8     3   9 1
            9     4  10 2
            10    4  11 1
            11    6  12 2
            12    7  13 1
            13    8  14 1
            14    9  15 2
            15   10  16 1
            16   11  17 2
            17   14  18 2
            18   16  19 2
            19   19  20 1
            20    6   8 1
            21   12  13 1
            22   15  18 1
            23   17  19 1

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