KEGG   DRUG: D00370Help
Entry
D00370                      Drug                                   

Name
Temazepam (USP/INN);
Restoril (TN)
Product
  Generic
TEMAZEPAM (A-S Medication Solutions LLC), TEMAZEPAM (Actavis Elizabeth LLC), TEMAZEPAM (Aphena Pharma Solutions - Tennessee), TEMAZEPAM (Aphena Pharma Solutions - Tennessee), TEMAZEPAM (Aphena Pharma Solutions - Tennessee), TEMAZEPAM (Aphena Pharma Solutions - Tennessee), TEMAZEPAM (Ascend Laboratories), TEMAZEPAM (Bryant Ranch Prepack), TEMAZEPAM (Bryant Ranch Prepack), TEMAZEPAM (Cardinal Health), TEMAZEPAM (Cardinal Health), TEMAZEPAM (Cardinal Health), TEMAZEPAM (DIRECT RX), TEMAZEPAM (Direct Rx), TEMAZEPAM (Golden State Medical Supply), TEMAZEPAM (H.J. Harkins Company), TEMAZEPAM (KAISER FOUNDATION HOSPITALS), TEMAZEPAM (Lake Erie Medical & Surgical Supply DBA Quality Care Products LLC), TEMAZEPAM (Lake Erie Medical DBA Quality Care Products LLC), TEMAZEPAM (Lake Erie Medical Surgical & Supply DBA Quality Care Products LLC), TEMAZEPAM (McKesson Contract Packaging), TEMAZEPAM (McKesson Packaging Services a business unit of McKesson Corporation), TEMAZEPAM (Mutual Pharmaceutical Company), TEMAZEPAM (Mylan Pharmaceuticals), TEMAZEPAM (Novel Laboratories), TEMAZEPAM (PD-Rx Pharmaceuticals), TEMAZEPAM (Physicians Total Care), TEMAZEPAM (Preferred Pharmaceuticals), TEMAZEPAM (Proficient Rx LP), TEMAZEPAM (REMEDYREPACK), TEMAZEPAM (REMEDYREPACK), TEMAZEPAM (Rebel Distributors Corp), TEMAZEPAM (Rebel Distributors Corp), TEMAZEPAM (RxChange), TEMAZEPAM (STAT Rx USA LLC), TEMAZEPAM (STAT Rx USA LLC), TEMAZEPAM (Sandoz), TEMAZEPAM (TYA Pharmaceuticals), TEMAZEPAM (UDL Laboratories), TEMAZEPAM (Unit Dose Services), TEMAZEPAM (Unit Dose Services), TEMAZEPAM (Unit Dose Services)
Formula
C16H13ClN2O2
Exact mass
300.0666
Mol weight
300.7396
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Tranquilizer [minor]
Remark
Same as: 
ATC code: 
Drug group: 
Comment
Temazepam is metabolite of Diazepam.
Target
GABAA-receptor (benzodiazepine binding site) agonist [HSA:2554 2555 2556 2557 2558 2559 2560 2561 2562 2563 2564 2565 2566 2567 2568 55879] [KO:K05175 K05181 K05184 K05185 K05186 K05189 K05192]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04727  GABAergic synapse  
 
Metabolism
Enzyme: CYP3A4 [HSA:1576]
Interaction
Drug interaction
Structure map
Anxiolytics
Hypnotics
GABA-A receptor agonists/antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N05 PSYCHOLEPTICS
   N05C HYPNOTICS AND SEDATIVES
    N05CD Benzodiazepine derivatives
     N05CD07 Temazepam
      D00370  Temazepam (USP/INN)
USP drug classification [BR:br08302]
 Sleep Disorder Agents
  GABA Receptor Modulators
   Temazepam
    D00370  Temazepam (USP/INN)
Target-based classification of drugs [BR:br08310]
 Ion channels
  Cys-loop superfamily
   GABA-A
    GABAA-receptor (benzodiazepine binding site)
     Temazepam
      D00370  Temazepam (USP/INN)
Cytochrome P450 interactions [BR:br08309]
 Substrates
  CYP3A4
   Temazepam
    D00370  Temazepam (USP/INN)
BRITE hierarchy
Other DBs
CAS: 
846-50-4
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        21
            1   C2y C    17.3534   -8.3394
            2   C8y C    16.5113   -7.2298
            3   C8y C    16.8465   -5.8730
            4   N1y N    18.1075   -5.2949
            5   N2x N    18.7592   -8.3646
            6   C5x C    19.3611   -5.9172
            7   C1y C    19.6476   -7.2859
            8   C8x C    15.8394   -4.9046
            9   C8x C    14.4974   -5.2927
            10  C8y C    14.1622   -6.6495
            11  C8x C    15.1693   -7.6176
            12  O1a O    20.9788   -7.7230
            13  O5x O    20.4052   -4.9828
            14  X   Cl   12.7974   -7.0439
            15  C8y C    16.7189   -9.5891
            16  C8x C    15.3173   -9.5891
            17  C8x C    14.6173  -10.8016
            18  C8x C    15.3173  -12.0140
            19  C8x C    16.7189  -12.0140
            20  C8x C    17.4189  -10.8016
            21  C1a C    18.1075   -3.8949
BOND        23
            1     3   4 1
            2     1   5 2
            3     4   6 1
            4     2   3 1
            5     5   7 1
            6     1   2 1
            7     6   7 1
            8     3   8 2
            9     8   9 1
            10    9  10 2
            11   10  11 1
            12    2  11 2
            13    7  12 1
            14    6  13 2
            15   10  14 1
            16    1  15 1
            17   15  16 1
            18   16  17 2
            19   17  18 1
            20   18  19 2
            21   19  20 1
            22   15  20 2
            23    4  21 1

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