KEGG   DRUG: D00375Help
Entry
D00375                      Drug                                   

Name
Mephenytoin (USP/INN);
Mesantoin (TN)
Formula
C12H14N2O2
Exact mass
218.1055
Mol weight
218.2518
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Anticonvulsant
Remark
ATC code: 
Comment
Hydantoins
Target
voltage-gated sodium channel (SCN1A) blocker [HSA:6323] [KO:K04833];
voltage-gated sodium channel (SCN2A) blocker [HSA:6326] [KO:K04834];
voltage-gated sodium channel (SCN3A) blocker [HSA:6328] [KO:K04836];
voltage-gated sodium channel (SCN4A) blocker [HSA:6329] [KO:K04837];
voltage-gated sodium channel (SCN5A) blocker [HSA:6331] [KO:K04838];
voltage-gated sodium channel (SCN8A) blocker [HSA:6334] [KO:K04840];
voltage-gated sodium channel (SCN9A) blocker [HSA:6335] [KO:K04841]
Metabolism
Enzyme: CYP2C19 [HSA:1557]
Interaction
Drug interaction
Structure map
Anticonvulsants
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N03 ANTIEPILEPTICS
   N03A ANTIEPILEPTICS
    N03AB Hydantoin derivatives
     N03AB04 Mephenytoin
      D00375  Mephenytoin (USP/INN)
Target-based classification of drugs [BR:br08310]
 Ion channels
  Voltage-gated cation channels
   Na+ channel, SCN alpha, NaV1.x
    voltage-gated sodium channel (SCN1A)
     Mephenytoin
      D00375  Mephenytoin (USP/INN)
    voltage-gated sodium channel (SCN2A)
     Mephenytoin
      D00375  Mephenytoin (USP/INN)
    voltage-gated sodium channel (SCN3A)
     Mephenytoin
      D00375  Mephenytoin (USP/INN)
    voltage-gated sodium channel (SCN4A)
     Mephenytoin
      D00375  Mephenytoin (USP/INN)
    voltage-gated sodium channel (SCN5A)
     Mephenytoin
      D00375  Mephenytoin (USP/INN)
    voltage-gated sodium channel (SCN8A)
     Mephenytoin
      D00375  Mephenytoin (USP/INN)
    voltage-gated sodium channel (SCN9A)
     Mephenytoin
      D00375  Mephenytoin (USP/INN)
Cytochrome P450 interactions [BR:br08309]
 Substrates
  CYP2C19
   Mephenytoin
    D00375  Mephenytoin (USP/INN)
BRITE hierarchy
Other DBs
CAS: 
50-12-4
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        16
            1   C1z C    20.8941  -17.2706
            2   C5x C    19.4767  -17.2762
            3   N1x N    21.3729  -15.9550
            4   N1y N    19.1015  -15.9329
            5   O5x O    18.6308  -18.4135
            6   C5x C    20.2356  -15.1090
            7   C1a C    17.7859  -15.4541
            8   O5x O    20.2300  -13.6917
            9   C8y C    22.2941  -17.2706
            10  C8x C    22.9937  -18.4823
            11  C8x C    24.3937  -18.4824
            12  C8x C    25.0937  -17.2699
            13  C8x C    24.3941  -16.0582
            14  C8x C    22.9941  -16.0581
            15  C1b C    20.8941  -18.6706
            16  C1a C    19.6477  -19.3902
BOND        17
            1     1   2 1
            2     1   3 1
            3     2   4 1
            4     2   5 2
            5     3   6 1
            6     4   7 1
            7     6   8 2
            8     4   6 1
            9     1   9 1
            10    9  10 2
            11   10  11 1
            12   11  12 2
            13   12  13 1
            14   13  14 2
            15    9  14 1
            16    1  15 1
            17   15  16 1

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