KEGG   DRUG: MephenytoinHelp
Entry
D00375                      Drug                                   

Name
Mephenytoin (USP/INN);
Mesantoin (TN)
Formula
C12H14N2O2
Exact mass
218.1055
Mol weight
218.2518
Structure
Mol fileKCF fileDB searchJmolKegDraw
Simcomp SIMCOMP
Class
Neuropsychiatric agent
 DG02031  Hydantoin antiepileptics
Cyp substrate
 DG01639  CYP2C19 substrate
Remark
ATC code: 
Activity
Anticonvulsant
Comment
Hydantoin derivative
Target
SCN1A [HSA:6323] [KO:K04833];
SCN2A [HSA:6326] [KO:K04834];
SCN3A [HSA:6328] [KO:K04836];
SCN4A [HSA:6329] [KO:K04837];
SCN5A [HSA:6331] [KO:K04838];
SCN8A [HSA:6334] [KO:K04840];
SCN9A [HSA:6335] [KO:K04841]
Metabolism
Enzyme: CYP2C19 [HSA:1557]
Interaction
Drug interaction
Structure map
Anticonvulsants
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N03 ANTIEPILEPTICS
   N03A ANTIEPILEPTICS
    N03AB Hydantoin derivatives
     N03AB04 Mephenytoin
      D00375  Mephenytoin (USP/INN)
Target-based classification of drugs [BR:br08310]
 Ion channels
  Voltage-gated cation channels
   Na+ channel, SCN alpha, NaV1.x
    voltage-gated sodium channel (SCN1A)
     Mephenytoin
      D00375  Mephenytoin (USP/INN)
    voltage-gated sodium channel (SCN2A)
     Mephenytoin
      D00375  Mephenytoin (USP/INN)
    voltage-gated sodium channel (SCN3A)
     Mephenytoin
      D00375  Mephenytoin (USP/INN)
    voltage-gated sodium channel (SCN4A)
     Mephenytoin
      D00375  Mephenytoin (USP/INN)
    voltage-gated sodium channel (SCN5A)
     Mephenytoin
      D00375  Mephenytoin (USP/INN)
    voltage-gated sodium channel (SCN8A)
     Mephenytoin
      D00375  Mephenytoin (USP/INN)
    voltage-gated sodium channel (SCN9A)
     Mephenytoin
      D00375  Mephenytoin (USP/INN)
Cytochrome P450 interactions [BR:br08309]
 CYP substrates
  CYP2C19
   Mephenytoin
    D00375  Mephenytoin (USP/INN)
BRITE hierarchy
Other DBs
CAS: 
50-12-4
PubChem: 
ChEBI: 
ChEMBL: 
DrugBank: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        16
            1   C1z C    20.8941  -17.2706
            2   C5x C    19.4767  -17.2762
            3   N1x N    21.3729  -15.9550
            4   N1y N    19.1015  -15.9329
            5   O5x O    18.6308  -18.4135
            6   C5x C    20.2356  -15.1090
            7   C1a C    17.7859  -15.4541
            8   O5x O    20.2300  -13.6917
            9   C8y C    22.2941  -17.2706
            10  C8x C    22.9937  -18.4823
            11  C8x C    24.3937  -18.4824
            12  C8x C    25.0937  -17.2699
            13  C8x C    24.3941  -16.0582
            14  C8x C    22.9941  -16.0581
            15  C1b C    20.8941  -18.6706
            16  C1a C    19.6477  -19.3902
BOND        17
            1     1   2 1
            2     1   3 1
            3     2   4 1
            4     2   5 2
            5     3   6 1
            6     4   7 1
            7     6   8 2
            8     4   6 1
            9     1   9 1
            10    9  10 2
            11   10  11 1
            12   11  12 2
            13   12  13 1
            14   13  14 2
            15    9  14 1
            16    1  15 1
            17   15  16 1

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