KEGG   DRUG: D00386Help
Entry
D00386                      Drug                                   

Name
Triamterene (JP16/USP/INN);
Dyrenium (TN)
Product
Formula
C12H11N7
Exact mass
253.1076
Mol weight
253.2626
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Diuretic
Remark
Therapeutic category: 
ATC code: 
Comment
potassium-sparing diuretic
Target
Epithelial sodium channel (SCNN) blocker [HSA:6337 6338 6340] [KO:K04824 K04825 K04827]
  Pathway
hsa04742  Taste transduction
hsa04960  Aldosterone-regulated sodium reabsorption  
 
Interaction
Drug interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 C CARDIOVASCULAR SYSTEM
  C03 DIURETICS
   C03D POTASSIUM-SPARING AGENTS
    C03DB Other potassium-sparing agents
     C03DB02 Triamterene
      D00386  Triamterene (JP16/USP/INN)
USP drug classification [BR:br08302]
 Cardiovascular Agents
  Diuretics, Potassium-sparing
   Triamterene
    D00386  Triamterene (JP16/USP/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  21  Cardiovascular agents
   213  Diuretics
    2133  Antialdosterones
     D00386  Triamterene (JP16/USP/INN)
Target-based classification of drugs [BR:br08310]
 Ion channels
  Epithelial and related channels
   Epithelial sodium channel (SCNN)
    renal epithelial Na+ channel (SCNN)
     Triamterene
      D00386  Triamterene (JP16/USP/INN)
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D00386  Triamterene
BRITE hierarchy
Other DBs
CAS: 
396-01-0
PubChem: 
DrugBank: 
PDB-CCD: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        19
            1   C8y C    23.7354  -19.6412
            2   C8y C    23.7354  -18.2292
            3   N5x N    24.9550  -20.3298
            4   N5x N    22.5099  -20.3357
            5   N5x N    24.9374  -17.5347
            6   C8y C    22.5216  -17.5407
            7   C8y C    26.1512  -19.6412
            8   C8y C    21.2962  -19.6412
            9   C8y C    26.1512  -18.2292
            10  N5x N    21.2962  -18.2409
            11  N1a N    22.5216  -16.1459
            12  N1a N    27.3649  -20.3298
            13  N1a N    20.0826  -20.3531
            14  C8y C    27.3532  -17.5114
            15  C8x C    27.3765  -16.1402
            16  C8x C    28.5961  -18.2116
            17  C8x C    28.5904  -15.4399
            18  C8x C    29.8040  -17.5114
            19  C8x C    29.8274  -16.1226
BOND        21
            1     1   2 1
            2     1   3 1
            3     1   4 2
            4     2   5 1
            5     2   6 2
            6     3   7 2
            7     4   8 1
            8     5   9 2
            9     6  10 1
            10    6  11 1
            11    7  12 1
            12    8  13 1
            13    9  14 1
            14   14  15 2
            15   14  16 1
            16   15  17 1
            17   16  18 2
            18   17  19 2
            19    7   9 1
            20    8  10 2
            21   18  19 1

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