KEGG   DRUG: D00387Help
Entry
D00387                      Drug                                   

Name
Triazolam (JAN/USP/INN);
Halcion (TN)
Product
  Generic
Formula
C17H12Cl2N4
Exact mass
342.0439
Mol weight
343.21
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Sedative-hypnotic
Remark
Therapeutic category: 
ATC code: 
Comment
Benzodiazepines
Target
GABAA-receptor (benzodiazepine binding site) agonist [HSA:2554 2555 2556 2557 2558 2559 2560 2561 2562 2563 2564 2565 2566 2567 2568 55879] [KO:K05175 K05181 K05184 K05185 K05186 K05189 K05192]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04727  GABAergic synapse  
 
Metabolism
Enzyme: CYP3A4 [HSA:1576]
Interaction
Drug interaction
Structure map
Hypnotics
GABA-A receptor agonists/antagonists
Brite
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  11  Agents affecting central nervous system
   112  Hypnotics and sedatives, anxiolytics
    1124  Benzodiazepins
     D00387  Triazolam (JAN/USP/INN)
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N05 PSYCHOLEPTICS
   N05C HYPNOTICS AND SEDATIVES
    N05CD Benzodiazepine derivatives
     N05CD05 Triazolam
      D00387  Triazolam (JAN/USP/INN)
Target-based classification of drugs [BR:br08310]
 Ion channels
  Cys-loop superfamily
   GABA-A
    GABAA-receptor (benzodiazepine binding site) [HSA:2554 2555 2556 2557 2558 2559 2560 2561 2562 2563 2564 2565 2566 2567 2568 55879] [KO:K05175 K05176 K05177 K05178 K05179 K05180 K05181 K05182 K05183 K05184 K05185 K05186 K05187 K05188 K05189 K05192]
     Triazolam [ATC:N05CD05]
      D00387  Triazolam (JAN/USP/INN)
BRITE hierarchy
Other DBs
CAS: 
28911-01-5
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        23
            1   C2y C    22.2631  -15.9778
            2   C8y C    21.4204  -14.7974
            3   C8y C    21.7559  -13.4397
            4   N4y N    23.0177  -12.8611
            5   N2x N    23.6699  -15.9330
            6   C8y C    24.2722  -13.4839
            7   C1x C    24.5589  -14.8536
            8   C8x C    20.7480  -12.4706
            9   C8x C    19.4051  -12.8589
            10  C8y C    19.0697  -14.2167
            11  C8x C    20.0775  -15.1855
            12  X   Cl   17.7039  -14.6114
            13  C8y C    21.6282  -17.1584
            14  C8x C    20.2256  -17.1584
            15  C8x C    19.5251  -18.3717
            16  C8x C    20.2256  -19.5850
            17  C8x C    21.6282  -19.5850
            18  C8y C    22.3287  -18.3717
            19  X   Cl   23.7406  -18.3718
            20  N5x N    25.2522  -12.4832
            21  N5x N    24.6033  -11.2420
            22  C8y C    23.2224  -11.4756
            23  C1a C    22.2334  -10.5070
BOND        26
            1     3   4 1
            2     1   5 2
            3     4   6 1
            4     2   3 1
            5     5   7 1
            6     1   2 1
            7     6   7 1
            8     3   8 2
            9     8   9 1
            10    9  10 2
            11   10  11 1
            12    2  11 2
            13   10  12 1
            14    1  13 1
            15   13  14 1
            16   14  15 2
            17   15  16 1
            18   16  17 2
            19   17  18 1
            20   13  18 2
            21   18  19 1
            22    6  20 2
            23   20  21 1
            24   21  22 2
            25    4  22 1
            26   22  23 1

» Japanese version   » Back

DBGET integrated database retrieval system