KEGG   DRUG: D00398Help
Entry
D00398                      Drug                                   

Name
Valaciclovir hydrochloride (JAN);
Valacyclovir hydrochloride (USAN);
Valtrex (TN)
Product
  Generic
VALACYCLOVIR (Ranbaxy Pharmaceuticals), VALACYCLOVIR HYDROCHLORIDE (Actavis), VALACYCLOVIR HYDROCHLORIDE (Aidarex Pharmaceuticals LLC), VALACYCLOVIR HYDROCHLORIDE (American Health Packaging), VALACYCLOVIR HYDROCHLORIDE (American Health Packaging), VALACYCLOVIR HYDROCHLORIDE (American Health Packaging), VALACYCLOVIR HYDROCHLORIDE (Aurobindo Pharma Limited), VALACYCLOVIR HYDROCHLORIDE (AvKARE), VALACYCLOVIR HYDROCHLORIDE (Bryant Ranch Prepack), VALACYCLOVIR HYDROCHLORIDE (Cardinal Health), VALACYCLOVIR HYDROCHLORIDE (Cardinal Health), VALACYCLOVIR HYDROCHLORIDE (Citron Pharma LLC), VALACYCLOVIR HYDROCHLORIDE (Clinical Solutions Wholesale), VALACYCLOVIR HYDROCHLORIDE (Dr. Reddys Laboratories Limited), VALACYCLOVIR (Gen-Source Rx), VALACYCLOVIR HYDROCHLORIDE (Greenstone LLC), VALACYCLOVIR HYDROCHLORIDE (H.J. Harkins Company), VALACYCLOVIR HYDROCHLORIDE (Jubilant Cadista Pharmaceuticals), VALACYCLOVIR HYDROCHLORIDE (Life Line Home Care Services), VALACYCLOVIR HYDROCHLORIDE (McKesson Packaging Services a business unit of McKesson Corporation), VALACYCLOVIR HYDROCHLORIDE (MedVantx), VALACYCLOVIR HYDROCHLORIDE (MedVantx), VALACYCLOVIR HYDROCHLORIDE (Mylan Institutional), VALACYCLOVIR HYDROCHLORIDE (Mylan Pharmaceuticals), VALACYCLOVIR HYDROCHLORIDE (NorthStar Rx LLC), VALACYCLOVIR (Ohm Laboratories), VALACYCLOVIR HYDROCHLORIDE (PD-Rx Pharmaceuticals), VALACYCLOVIR HYDROCHLORIDE (PD-Rx Pharmaceuticals), VALACYCLOVIR HYDROCHLORIDE (Physicians Total Care), VALACYCLOVIR HYDROCHLORIDE (Preferred Pharmaceuticals), VALACYCLOVIR HYDROCHLORIDE (REMEDYREPACK), VALACYCLOVIR HYDROCHLORIDE (REMEDYREPACK), VALACYCLOVIR HYDROCHLORIDE (REMEDYREPACK), VALACYCLOVIR HYDROCHLORIDE (Rebel Distributors Corp), VALACYCLOVIR HYDROCHLORIDE (Rebel Distributors Corp), VALACYCLOVIR HYDROCHLORIDE (Roxane Laboratories), VALACYCLOVIR HYDROCHLORIDE (Sandoz), VALACYCLOVIR HYDROCHLORIDE (Teva Pharmaceuticals USA), VALACYCLOVIR HYDROCHLORIDE (Watson Laboratories), VALACYCLOVIR HYDROCHLORIDE (Wockhardt Limited), VALACYCLOVIR HYDROCHLORIDE (Wockhardt USA LLC.)
Formula
C13H20N6O4. HCl
Exact mass
360.1313
Mol weight
360.7966
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Antiviral [DS:H00365]
Remark
Same as: 
Therapeutic category: 
ATC code: 
Comment
prodrug, active substance: Aciclovir [DR:D00222]
Target
DNA polymerase inhibitor
Metabolism
Transporter: SLC15A1 [HSA:6564], SCL15A2 [HSA:6565]
Interaction
Drug interaction
Structure map
Antiviral agents
Brite
Therapeutic category of drugs in Japan [BR:br08301]
 6  Agents against pathologic organisms and parasites
  62  Chemotherapeutics
   625  Antivirals
    6250  Antivirals
     D00398  Valaciclovir hydrochloride (JAN); Valacyclovir hydrochloride (USAN)
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 J ANTIINFECTIVES FOR SYSTEMIC USE
  J05 ANTIVIRALS FOR SYSTEMIC USE
   J05A DIRECT ACTING ANTIVIRALS
    J05AB Nucleosides and nucleotides excl. reverse transcriptase inhibitors
     J05AB11 Valaciclovir
      D00398  Valaciclovir hydrochloride (JAN); Valacyclovir hydrochloride (USAN)
USP drug classification [BR:br08302]
 Antivirals
  Antiherpetic Agents
   Valacyclovir
    D00398  Valaciclovir hydrochloride (JAN); Valacyclovir hydrochloride (USAN)
Antiinfectives [BR:br08307]
 Antivirals
  Anti-HSV agent
   DNA polymerase inhibitor
    Purine analogue
     Valacyclovir [ATC:J05AB11]
      D00398  Valaciclovir hydrochloride (JAN); Valacyclovir hydrochloride (USAN)
BRITE hierarchy
Other DBs
CAS: 
124832-27-5
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        24
            1   X   Cl   33.8079  -15.4658
            2   N4y N    26.2500  -17.2200
            3   C8y C    27.5100  -16.7300
            4   C8y C    27.5100  -15.3300
            5   N5x N    26.1800  -14.9100
            6   C8x C    25.4100  -16.1000
            7   N5x N    28.7700  -17.4300
            8   C8y C    29.9600  -16.7300
            9   N4x N    29.9600  -15.3300
            10  C8y C    28.7000  -14.5600
            11  O5x O    28.7000  -13.1600
            12  N1a N    31.2200  -17.3600
            13  C1b C    26.2500  -18.6200
            14  O2a O    24.9900  -19.3200
            15  C1b C    23.8000  -18.6200
            16  C1b C    22.5400  -19.3200
            17  O7a O    21.3500  -18.6200
            18  C7a C    20.0900  -19.2500
            19  C1c C    18.9000  -18.6200
            20  C1c C    17.7100  -19.2500
            21  C1a C    16.5200  -18.5500
            22  C1a C    17.7100  -20.7200
            23  O6a O    20.0900  -20.7200
            24  N1a N    18.9000  -17.2200
BOND        24
            1     2   3 1
            2     3   4 2
            3     4   5 1
            4     5   6 2
            5     2   6 1
            6     3   7 1
            7     7   8 2
            8     8   9 1
            9     9  10 1
            10    4  10 1
            11   10  11 2
            12    8  12 1
            13    2  13 1
            14   13  14 1
            15   14  15 1
            16   15  16 1
            17   16  17 1
            18   17  18 1
            19   18  19 1
            20   19  20 1
            21   20  21 1
            22   20  22 1
            23   18  23 2
            24   19  24 1 #Down

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