KEGG   DRUG: Valacyclovir hydrochlorideHelp
Entry
D00398                      Drug                                   

Name
Valacyclovir hydrochloride (USAN);
Valaciclovir hydrochloride (JP17);
Valtrex (TN)
Product
  Generic
VALACYCLOVIR (Bryant Ranch Prepack), VALACYCLOVIR (Bryant Ranch Prepack), VALACYCLOVIR (Cadila Healthcare Limited), VALACYCLOVIR (Camber Pharmaceuticals), VALACYCLOVIR (Direct Rx), VALACYCLOVIR (Direct Rx), VALACYCLOVIR (NuCare Pharmaceuticals), VALACYCLOVIR (NuCare Pharmaceuticals), VALACYCLOVIR (NuCare Pharmaceuticals), VALACYCLOVIR (PD-Rx Pharmaceuticals), VALACYCLOVIR (Proficient Rx LP), VALACYCLOVIR (REMEDYREPACK), VALACYCLOVIR (Ranbaxy Pharmaceuticals), VALACYCLOVIR (Teva Pharmaceuticals USA), VALACYCLOVIR (West-Ward Pharmaceuticals Corp.), VALACYCLOVIR (Zydus Pharmaceuticals (USA)), VALACYCLOVIR HYDROCHLORIDE (Actavis Pharma), VALACYCLOVIR HYDROCHLORIDE (Actavis Pharma), VALACYCLOVIR HYDROCHLORIDE (Aidarex Pharmaceuticals LLC), VALACYCLOVIR HYDROCHLORIDE (American Health Packaging), VALACYCLOVIR (Aphena Pharma Solutions - Tennessee), VALACYCLOVIR HYDROCHLORIDE (Aurobindo Pharma Limited), VALACYCLOVIR HYDROCHLORIDE (AvPAK), VALACYCLOVIR HYDROCHLORIDE (Avera McKennan Hospital), VALACYCLOVIR HYDROCHLORIDE (Blenheim Pharmacal), VALACYCLOVIR HYDROCHLORIDE (Bryant Ranch Prepack), VALACYCLOVIR HYDROCHLORIDE (Bryant Ranch Prepack), VALACYCLOVIR HYDROCHLORIDE (Bryant Ranch Prepack), VALACYCLOVIR HYDROCHLORIDE (Bryant Ranch Prepack), VALACYCLOVIR HYDROCHLORIDE (Cardinal Health), VALACYCLOVIR HYDROCHLORIDE (Cipla USA), VALACYCLOVIR HYDROCHLORIDE (Dr. Reddys Laboratories Limited), VALACYCLOVIR HYDROCHLORIDE (H.J. Harkins Company), VALACYCLOVIR HYDROCHLORIDE (Jubilant Cadista Pharmaceuticals), VALACYCLOVIR (LUCID PHARMA LLC), VALACYCLOVIR HYDROCHLORIDE (Lake Erie Medical DBA Quality Care Products LLC), VALACYCLOVIR HYDROCHLORIDE (Lake Erie Medical DBA Quality Care Products LLC), VALACYCLOVIR HYDROCHLORIDE (Life Line Home Care Services), VALACYCLOVIR HYDROCHLORIDE (Major Pharmaceuticals), VALACYCLOVIR HYDROCHLORIDE (McKesson Corporation), VALACYCLOVIR HYDROCHLORIDE (MedVantx), VALACYCLOVIR HYDROCHLORIDE (MedVantx), VALACYCLOVIR HYDROCHLORIDE (Mylan Institutional), VALACYCLOVIR HYDROCHLORIDE (Mylan Pharmaceuticals), VALACYCLOVIR HYDROCHLORIDE (NorthStar Rx LLC), VALACYCLOVIR HYDROCHLORIDE (Northwind Pharmaceuticals), VALACYCLOVIR HYDROCHLORIDE (NuCare Pharmaceuticals), VALACYCLOVIR HYDROCHLORIDE (NuCare Pharmaceuticals), VALACYCLOVIR HYDROCHLORIDE (NuCare Pharmaceuticals), VALACYCLOVIR HYDROCHLORIDE (NuCare Pharmaceuticals), VALACYCLOVIR HYDROCHLORIDE (NuCare Pharmaceuticals), VALACYCLOVIR HYDROCHLORIDE (NuCare Pharmaceuticals), VALACYCLOVIR HYDROCHLORIDE (NuCare Pharmaceuticals), VALACYCLOVIR HYDROCHLORIDE (NuCare Pharmaceuticals), VALACYCLOVIR HYDROCHLORIDE (NuCare Pharmacuticals), VALACYCLOVIR (Ohm Laboratories), VALACYCLOVIR HYDROCHLORIDE (PD-Rx Pharmaceuticals), VALACYCLOVIR HYDROCHLORIDE (PD-Rx Pharmaceuticals), VALACYCLOVIR HYDROCHLORIDE (PD-Rx Pharmaceuticals), VALACYCLOVIR HYDROCHLORIDE (PD-Rx Pharmaceuticals), VALACYCLOVIR HYDROCHLORIDE (PD-Rx Pharmaceuticals), VALACYCLOVIR HYDROCHLORIDE (PD-Rx Pharmaceuticals), VALACYCLOVIR HYDROCHLORIDE (Physicians Total Care), VALACYCLOVIR HYDROCHLORIDE (Preferred Pharmaceuticals), VALACYCLOVIR HYDROCHLORIDE (Preferred Pharmaceuticals), VALACYCLOVIR HYDROCHLORIDE (Preferred Pharmaceuticals), VALACYCLOVIR HYDROCHLORIDE (Preferred Pharmaceuticals), VALACYCLOVIR HYDROCHLORIDE (Preferred Pharmaceuticals), VALACYCLOVIR HYDROCHLORIDE (Preferred Pharmaceuticals), VALACYCLOVIR HYDROCHLORIDE (Proficient Rx LP), VALACYCLOVIR HYDROCHLORIDE (Proficient Rx LP), VALACYCLOVIR HYDROCHLORIDE (Proficient Rx LP), VALACYCLOVIR HYDROCHLORIDE (Proficient Rx LP), VALACYCLOVIR HYDROCHLORIDE (Proficient Rx LP), VALACYCLOVIR HYDROCHLORIDE (REMEDYREPACK), VALACYCLOVIR HYDROCHLORIDE (REMEDYREPACK), VALACYCLOVIR HYDROCHLORIDE (REMEDYREPACK), VALACYCLOVIR HYDROCHLORIDE (RPK Pharmaceuticals), VALACYCLOVIR HYDROCHLORIDE (Rebel Distributors Corp), VALACYCLOVIR HYDROCHLORIDE (Rebel Distributors Corp), VALACYCLOVIR HYDROCHLORIDE (Rising Health), VALACYCLOVIR HYDROCHLORIDE (Sandoz), VALACYCLOVIR HYDROCHLORIDE (State of Florida DOH Central Pharmacy), VALACYCLOVIR HYDROCHLORIDE (Wockhardt Limited), VALACYCLOVIR HYDROCHLORIDE (Wockhardt USA LLC.)
Formula
C13H20N6O4. HCl
Exact mass
360.1313
Mol weight
360.7966
Structure
Mol fileKCF fileDB searchJmolKegDraw
Simcomp SIMCOMP
Class
Antiviral
 DG02840  Herpesvirus DNA polymerase inhibitor
Remark
Same as: C07184
Therapeutic category: 6250
ATC code: J05AB11
Chemical structure group: DG00647
Product (DG00647): D00398<JP/US> D10518<JP>
Efficacy
Antiviral, DNA polymerase inhibitor
  Disease
Herpes labialis [DS:H00365]
Genital herpes [DS:H00365]
Herpes zoster [DS:H00366]
Chickenpox [DS:H00366]
Comment
Active form of prodrug: Aciclovir [DR:D00222]
Target
Herpesvirus DNA polymerase [KO:K18964]
Metabolism
Transporter: SLC15A1 [HSA:6564], SLC15A2 [HSA:6565]
Interaction
Drug interaction
Structure map
map07044  Antiviral agents
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 J ANTIINFECTIVES FOR SYSTEMIC USE
  J05 ANTIVIRALS FOR SYSTEMIC USE
   J05A DIRECT ACTING ANTIVIRALS
    J05AB Nucleosides and nucleotides excl. reverse transcriptase inhibitors
     J05AB11 Valaciclovir
      D00398  Valacyclovir hydrochloride (USAN) <JP/US>
USP drug classification [BR:br08302]
 Antivirals
  Antiherpetic Agents
   Valacyclovir
    D00398  Valacyclovir hydrochloride (USAN)
Therapeutic category of drugs in Japan [BR:br08301]
 6  Agents against pathologic organisms and parasites
  62  Chemotherapeutics
   625  Antivirals
    6250  Antivirals
     D00398  Valacyclovir hydrochloride (USAN); Valaciclovir hydrochloride (JP17)
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D00398  Valaciclovir hydrochloride
  D00398  Valaciclovir hydrochloride tablets
Antiinfectives [br08350.html]
 Antivirals
  D00398
New drug approvals in Japan [br08318.html]
 Drugs with new active ingredients
  D00398
Prodrugs [br08324.html]
 DG00647
BRITE hierarchy
Other DBs
CAS: 124832-27-5
PubChem: 7847464
ChEBI: 9919
ChEMBL: CHEMBL1201110
DrugBank: DB00577
LigandBox: D00398
NIKKAJI: J1.402.670C
KCF data Show

ATOM        24
            1   X   Cl   33.8079  -15.4658
            2   N4y N    26.2500  -17.2200
            3   C8y C    27.5100  -16.7300
            4   C8y C    27.5100  -15.3300
            5   N5x N    26.1800  -14.9100
            6   C8x C    25.4100  -16.1000
            7   N5x N    28.7700  -17.4300
            8   C8y C    29.9600  -16.7300
            9   N4x N    29.9600  -15.3300
            10  C8y C    28.7000  -14.5600
            11  O5x O    28.7000  -13.1600
            12  N1a N    31.2200  -17.3600
            13  C1b C    26.2500  -18.6200
            14  O2a O    24.9900  -19.3200
            15  C1b C    23.8000  -18.6200
            16  C1b C    22.5400  -19.3200
            17  O7a O    21.3500  -18.6200
            18  C7a C    20.0900  -19.2500
            19  C1c C    18.9000  -18.6200
            20  C1c C    17.7100  -19.2500
            21  C1a C    16.5200  -18.5500
            22  C1a C    17.7100  -20.7200
            23  O6a O    20.0900  -20.7200
            24  N1a N    18.9000  -17.2200
BOND        24
            1     2   3 1
            2     3   4 2
            3     4   5 1
            4     5   6 2
            5     2   6 1
            6     3   7 1
            7     7   8 2
            8     8   9 1
            9     9  10 1
            10    4  10 1
            11   10  11 2
            12    8  12 1
            13    2  13 1
            14   13  14 1
            15   14  15 1
            16   15  16 1
            17   16  17 1
            18   17  18 1
            19   18  19 1
            20   19  20 1
            21   20  21 1
            22   20  22 1
            23   18  23 2
            24   19  24 1 #Down

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