KEGG   DRUG: Valacyclovir hydrochlorideHelp
Entry
D00398                      Drug                                   

Name
Valacyclovir hydrochloride (USAN);
Valaciclovir hydrochloride (JP17);
Valtrex (TN)
Product
  Generic
VALACYCLOVIR (Bryant Ranch Prepack), VALACYCLOVIR (Camber Pharmaceuticals), DIRECT RX (Direct Rx), DIRECT RX (Direct Rx), VALACYCLOVIR (Ranbaxy Pharmaceuticals), VALACYCLOVIR (Teva Pharmaceuticals USA), VALACYCLOVIR (West-Ward Pharmaceuticals Corp.), VALACYCLOVIR HYDROCHLORIDE (A-S Medication Solutions), VALACYCLOVIR HYDROCHLORIDE (A-S Medication Solutions), VALACYCLOVIR HYDROCHLORIDE (A-S Medication Solutions), VALACYCLOVIR HYDROCHLORIDE (Actavis Pharma), VALACYCLOVIR HYDROCHLORIDE (Aidarex Pharmaceuticals LLC), VALACYCLOVIR HYDROCHLORIDE (American Health Packaging), VALACYCLOVIR (Aphena Pharma Solutions - Tennessee), VALACYCLOVIR HYDROCHLORIDE (Aurobindo Pharma Limited), VALACYCLOVIR HYDROCHLORIDE (AvPAK), VALACYCLOVIR HYDROCHLORIDE (Avera McKennan Hospital), VALACYCLOVIR HYDROCHLORIDE (Blenheim Pharmacal), VALACYCLOVIR HYDROCHLORIDE (Bryant Ranch Prepack), VALACYCLOVIR HYDROCHLORIDE (Cardinal Health), VALACYCLOVIR HYDROCHLORIDE (Cardinal Health), VALACYCLOVIR HYDROCHLORIDE (Cardinal Health), VALACYCLOVIR HYDROCHLORIDE (Cipla USA), VALACYCLOVIR HYDROCHLORIDE (Citron Pharma LLC), VALACYCLOVIR HYDROCHLORIDE (Clinical Solutions Wholesale), VALACYCLOVIR HYDROCHLORIDE (Dr. Reddys Laboratories Limited), VALACYCLOVIR HYDROCHLORIDE (H.J. Harkins Company), VALACYCLOVIR HYDROCHLORIDE (Jubilant Cadista Pharmaceuticals), VALACYCLOVIR (LUCID PHARMA LLC), VALACYCLOVIR HYDROCHLORIDE (Lake Erie Medical DBA Quality Care Products LLC), VALACYCLOVIR HYDROCHLORIDE (Lake Erie Medical DBA Quality Care Products LLC), VALACYCLOVIR HYDROCHLORIDE (Life Line Home Care Services), VALACYCLOVIR HYDROCHLORIDE (McKesson Packaging Services a business unit of McKesson Corporation), VALACYCLOVIR HYDROCHLORIDE (MedVantx), VALACYCLOVIR HYDROCHLORIDE (MedVantx), VALACYCLOVIR HYDROCHLORIDE (Mylan Institutional), VALACYCLOVIR HYDROCHLORIDE (Mylan Pharmaceuticals), VALACYCLOVIR HYDROCHLORIDE (NorthStar Rx LLC), VALACYCLOVIR HYDROCHLORIDE (Northwind Pharmaceuticals), VALACYCLOVIR (Ohm Laboratories), VALACYCLOVIR HYDROCHLORIDE (PD-Rx Pharmaceuticals), VALACYCLOVIR HYDROCHLORIDE (PD-Rx Pharmaceuticals), VALACYCLOVIR HYDROCHLORIDE (PD-Rx Pharmaceuticals), VALACYCLOVIR HYDROCHLORIDE (Physicians Total Care), VALACYCLOVIR HYDROCHLORIDE (Preferred Pharmaceuticals), VALACYCLOVIR HYDROCHLORIDE (Preferred Pharmaceuticals), VALACYCLOVIR HYDROCHLORIDE (Preferred Pharmaceuticals), VALACYCLOVIR HYDROCHLORIDE (Preferred Pharmaceuticals), VALACYCLOVIR HYDROCHLORIDE (Proficient Rx LP), VALACYCLOVIR HYDROCHLORIDE (Proficient Rx LP), VALACYCLOVIR HYDROCHLORIDE (Proficient Rx LP), VALACYCLOVIR HYDROCHLORIDE (REMEDYREPACK), VALACYCLOVIR HYDROCHLORIDE (REMEDYREPACK), VALACYCLOVIR HYDROCHLORIDE (REMEDYREPACK), VALACYCLOVIR HYDROCHLORIDE (REMEDYREPACK), VALACYCLOVIR HYDROCHLORIDE (Rebel Distributors Corp), VALACYCLOVIR HYDROCHLORIDE (Rebel Distributors Corp), VALACYCLOVIR HYDROCHLORIDE (Sandoz), VALACYCLOVIR HYDROCHLORIDE (State of Florida DOH Central Pharmacy), VALACYCLOVIR HYDROCHLORIDE (Watson Laboratories), VALACYCLOVIR HYDROCHLORIDE (Wockhardt Limited), VALACYCLOVIR HYDROCHLORIDE (Wockhardt USA LLC.)
Formula
C13H20N6O4. HCl
Exact mass
360.1313
Mol weight
360.7966
Structure
Mol fileKCF fileDB searchJmolKegDraw
Remark
Same as: 
Therapeutic category: 
ATC code: 
Chemical group: 
Activity
Antiviral, DNA polymerase inhibitor
Comment
Active form of prodrug: Aciclovir [DR:D00222]
Acyclovir type
Target
DNA polymerase
Metabolism
Transporter: SLC15A1 [HSA:6564], SCL15A2 [HSA:6565]
Interaction
Drug interaction
Structure map
Antiviral agents
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 J ANTIINFECTIVES FOR SYSTEMIC USE
  J05 ANTIVIRALS FOR SYSTEMIC USE
   J05A DIRECT ACTING ANTIVIRALS
    J05AB Nucleosides and nucleotides excl. reverse transcriptase inhibitors
     J05AB11 Valaciclovir
      D00398  Valacyclovir hydrochloride (USAN)
USP drug classification [BR:br08302]
 Antivirals
  Antiherpetic Agents
   Valacyclovir
    D00398  Valacyclovir hydrochloride (USAN)
Therapeutic category of drugs in Japan [BR:br08301]
 6  Agents against pathologic organisms and parasites
  62  Chemotherapeutics
   625  Antivirals
    6250  Antivirals
     D00398  Valacyclovir hydrochloride (USAN); Valaciclovir hydrochloride (JP17)
Antiinfectives [BR:br08307]
 Antivirals
  Anti-HSV agents
   DNA polymerase inhibitor
    Purine analogue
     Valacyclovir
      D00398  Valacyclovir hydrochloride (USAN)
Cytochrome P450 interactions [BR:br08309]
 Transporter substrates
  SLC15A1
   Valaciclovir
    D00398  Valacyclovir hydrochloride (USAN)
  SCL15A2
   Valaciclovir
    D00398  Valacyclovir hydrochloride (USAN)
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D00398  Valaciclovir hydrochloride
  D00398  Valaciclovir hydrochloride tablets
Antivirals [br08351.html]
 D00398
BRITE hierarchy
Other DBs
CAS: 
124832-27-5
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        24
            1   X   Cl   33.8079  -15.4658
            2   N4y N    26.2500  -17.2200
            3   C8y C    27.5100  -16.7300
            4   C8y C    27.5100  -15.3300
            5   N5x N    26.1800  -14.9100
            6   C8x C    25.4100  -16.1000
            7   N5x N    28.7700  -17.4300
            8   C8y C    29.9600  -16.7300
            9   N4x N    29.9600  -15.3300
            10  C8y C    28.7000  -14.5600
            11  O5x O    28.7000  -13.1600
            12  N1a N    31.2200  -17.3600
            13  C1b C    26.2500  -18.6200
            14  O2a O    24.9900  -19.3200
            15  C1b C    23.8000  -18.6200
            16  C1b C    22.5400  -19.3200
            17  O7a O    21.3500  -18.6200
            18  C7a C    20.0900  -19.2500
            19  C1c C    18.9000  -18.6200
            20  C1c C    17.7100  -19.2500
            21  C1a C    16.5200  -18.5500
            22  C1a C    17.7100  -20.7200
            23  O6a O    20.0900  -20.7200
            24  N1a N    18.9000  -17.2200
BOND        24
            1     2   3 1
            2     3   4 2
            3     4   5 1
            4     5   6 2
            5     2   6 1
            6     3   7 1
            7     7   8 2
            8     8   9 1
            9     9  10 1
            10    4  10 1
            11   10  11 2
            12    8  12 1
            13    2  13 1
            14   13  14 1
            15   14  15 1
            16   15  16 1
            17   16  17 1
            18   17  18 1
            19   18  19 1
            20   19  20 1
            21   20  21 1
            22   20  22 1
            23   18  23 2
            24   19  24 1 #Down

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