| Entry |
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| Name |
Valproic acid (USP);
Depakene (TN)
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| Product |
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| Generic |
VALPROATE (APP Pharmaceuticals), VALPROIC ACID (Caraco Pharmaceutical Laboratories), VALPROIC ACID (Cardinal Health), VALPROIC (Contract Pharmacy Services-PA), VALPROIC (Contract Pharmacy Services-PA), VALPROIC ACID (Hi-Tech Pharmacal), VALPROIC ACID (McKesson Packaging Services Business Unit of McKesson Corporation), VALPROIC ACID (Morton Grove Pharmaceuticals), VALPROIC ACID (Mylan Institutional), VALPROIC ACID (NCS HealthCare of KY), VALPROIC ACID (Pharmaceutical Associates), VALPROIC (Physicians Total Care), VALPROIC ACID (Pliva), VALPROIC ACID (Precision Dose), VALPROIC ACID (Qualitest Pharmaceuticals), VALPROIC ACID (REMEDYREPACK), VALPROIC ACID (Rebel Distributors Corp), VALPROIC ACID (Sun Pharmaceutical Industries Limited), VALPROIC ACID (Upsher-Smith Laboratories), VALPROIC ACID (Watson Laboratories), VALPROIC (Watson Laboratories) |
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| Formula |
C8H16O2
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| Exact mass |
144.115
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| Mol weight |
144.2114
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| Structure |
     |
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| Activity |
Anticonvulsant
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| Remark |
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| Comment |
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| Target |
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| Pathway |
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| Metabolism |
Enzyme: CYP2C9 [HSA: 1559], CYP3A4 [HSA: 1576]
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| Interaction |
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| Pathway map |
| Drug metabolism - cytochrome P450 |
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| Structure map |
| Anticonvulsants | | Calcium channel blocking drugs | | Antimigraines |
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| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
N NERVOUS SYSTEM
N03 ANTIEPILEPTICS
N03A ANTIEPILEPTICS
N03AG Fatty acid derivatives
N03AG01 Valproic acid
D00399 Valproic acid (USP)
USP drug classification [BR:br08302]
Anticonvulsants
Gamma-aminobutyric Acid (GABA) Augmenting Agents
Valproate
D00399 Valproic acid (USP)
Antimigraine Agents
Prophylactic
Non Beta-adrenergic Blocking Agents
Valproic acid
D00399 Valproic acid (USP)
Bipolar Agents
Mood Stabilizers
Valproic acid
D00399 Valproic acid (USP)
Target-based classification of drugs [BR:br08310]
Ion channels
Voltage-gated cation channels
Ca2+ channel, CACN alpha-1, CaVx.x
calcium channel T type [HSA:8911 8912 8913] [KO:K04856 K04855 K04854]
Valproic acid [ATC:N03AG01]
D00399 Valproic acid (USP)
Enzymes
Transferases
histone acetyltransferase [HSA:203611 253175 9085 9426] [KO:K00653]
Valproic acid [ATC:N03AG01]
D00399 Valproic acid (USP)
GABA transaminase [HSA:18] [KO:K13524]
Valproic acid [ATC:N03AG01]
D00399 Valproic acid (USP)
Hydrolases
histone deacetylase [HSA:3065 3066 8841 9759 10014 10013 51564 55869 9734 83933] [KO:K06067 K11404 K11405 K11406 K11407 K11408 K11409]
Valproic acid [ATC:N03AG01]
D00399 Valproic acid (USP)
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| Other DBs |
CAS: 99-66-1 PubChem: DrugBank: PDB-CCD: LigandBox: NIKKAJI: |
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| KCF data |
ATOM 10
1 C1c C 25.4573 -18.6784
2 C1b C 25.4573 -17.3002
3 C1b C 24.2485 -19.3967
4 C6a C 26.6604 -19.3967
5 C1b C 24.2427 -16.5935
6 C1b C 23.0396 -18.6784
7 O6a O 26.6604 -20.7925
8 O6a O 27.8692 -18.6784
9 C1a C 23.0339 -17.3002
10 C1a C 21.8367 -19.3967
BOND 9
1 1 2 1
2 1 3 1
3 1 4 1
4 2 5 1
5 3 6 1
6 4 7 1
7 4 8 2
8 5 9 1
9 6 10 1
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