KEGG   DRUG: D00400Help
Entry
D00400                      Drug                                   

Name
Valsartan (JP16/USAN/INN);
Diovan (TN)
Product
  Generic
Formula
C24H29N5O3
Exact mass
435.227
Mol weight
435.5188
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Antihypertensive
Remark
Therapeutic category: 
ATC code: 
Target
angiotensin II receptor type 1 (AT1) antagonist [HSA:185] [KO:K04166]
  Pathway
hsa04020  Calcium signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04270  Vascular smooth muscle contraction
hsa04614  Renin-angiotensin system  
 
Metabolism
Enzyme: CYP2C9 [HSA:1559]
Transporter: SLCO1B1 [HSA:10599], SLCO1B3 [HSA:28234], ABCC2 [HSA:1244]
Interaction
Drug interaction
Structure map
Angiotensin receptor and endothelin receptor antagonists
Other map
Bile secretion
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 C CARDIOVASCULAR SYSTEM
  C09 AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM
   C09C ANGIOTENSIN II ANTAGONISTS, PLAIN
    C09CA Angiotensin II antagonists, plain
     C09CA03 Valsartan
      D00400  Valsartan (JAN/USAN/INN)
USP drug classification [BR:br08302]
 Cardiovascular Agents
  Angiotensin II Receptor Antagonists
   Valsartan
    D00400  Valsartan (JAN/USAN/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  21  Cardiovascular agents
   214  Antihypertensives
    2149  Others
     D00400  Valsartan (JP16/USAN/INN)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Angiotensin
    angiotensin II stimulates angiotensin subtype 1 (AT1) receptor
     Valsartan
      D00400  Valsartan (JAN/USAN/INN)
Cytochrome P450 interactions [BR:br08309]
 Substrates
  CYP2C9
   Valsartan
    D00400  Valsartan (JP16/USAN/INN)
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D00400  Valsartan
  D00400  Valsartan tablets
BRITE hierarchy
Other DBs
CAS: 
137862-53-4
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        32
            1   C8x C    19.4226  -22.2154
            2   C8x C    19.4226  -23.6234
            3   C8x C    20.6194  -24.3274
            4   C8x C    21.8865  -23.6234
            5   C8y C    21.8865  -22.2154
            6   C8y C    20.6194  -21.5115
            7   C8y C    23.0833  -21.5115
            8   C8x C    24.2801  -22.2154
            9   C8x C    25.5472  -21.5115
            10  C8y C    25.5472  -20.1035
            11  C8x C    24.3504  -19.3995
            12  C8x C    23.0833  -20.1035
            13  C8y C    20.6194  -20.1035
            14  N4x N    21.7457  -19.2587
            15  N5x N    21.3233  -17.9916
            16  N5x N    19.9154  -17.9916
            17  N5x N    19.4930  -19.2587
            18  C1b C    26.7440  -19.3995
            19  N1c N    26.7440  -17.9916
            20  C1c C    27.9407  -17.2876
            21  C5a C    25.5472  -17.2876
            22  O5a O    24.3504  -17.9916
            23  C1b C    25.5472  -15.8797
            24  C1b C    24.3504  -15.1757
            25  C1b C    24.3504  -13.7677
            26  C1a C    23.1537  -13.0637
            27  C6a C    29.1375  -17.9916
            28  O6a O    30.3343  -17.2876
            29  O6a O    29.1375  -19.3995
            30  C1c C    27.9407  -15.8797
            31  C1a C    26.7440  -15.1757
            32  C1a C    29.1375  -15.1757
BOND        34
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     5   7 1
            8     7   8 2
            9     8   9 1
            10    9  10 2
            11   10  11 1
            12   11  12 2
            13    7  12 1
            14    6  13 1
            15   13  14 1
            16   14  15 1
            17   15  16 2
            18   16  17 1
            19   13  17 2
            20   10  18 1
            21   18  19 1
            22   19  20 1
            23   19  21 1
            24   21  22 2
            25   21  23 1
            26   23  24 1
            27   24  25 1
            28   25  26 1
            29   20  27 1
            30   27  28 2
            31   27  29 1
            32   20  30 1 #Up
            33   30  31 1
            34   30  32 1

» Japanese version   » Back

DBGET integrated database retrieval system