KEGG   DRUG: ValsartanHelp
Entry
D00400                      Drug                                   

Name
Valsartan (JP17/USAN/INN);
Diovan (TN)
Product
  Generic
VALSARTAN (Actavis Pharma), VALSARTAN (Alembic Pharmaceuticals), VALSARTAN (Alembic Pharmaceuticals Limited), VALSARTAN (American Health Packaging), VALSARTAN (Amneal Pharmaceuticals of New York), VALSARTAN (Aphena Pharma Solutions - Tennessee), VALSARTAN (Aphena Pharma Solutions - Tennessee), VALSARTAN (Aurobindo Pharma Limited), VALSARTAN (AvKARE), VALSARTAN (AvKARE), VALSARTAN (AvPAK), VALSARTAN (Avera McKennan Hospital), VALSARTAN (Camber Pharmaceuticals), VALSARTAN (Cardinal Health), VALSARTAN (Jubilant Cadista Pharmaceuticals), VALSARTAN (Lake Erie Medical DBA Quality Care Products LLC), VALSARTAN (Lupin Pharmaceuticals), VALSARTAN (Mylan Pharmaceuticals), VALSARTAN (Northwind Pharmaceuticals), VALSARTAN (Northwind Pharmaceuticals), VALSARTAN (Ohm Laboratories), VALSARTAN (Physicians Total Care), VALSARTAN (Proficient Rx LP), VALSARTAN (Qualitest Pharmaceuticals), VALSARTAN (REMEDYREPACK), VALSARTAN (REMEDYREPACK), VALSARTAN (REMEDYREPACK), VALSARTAN (Sandoz), VALSARTAN (Solco Healthcare US), VALSARTAN (Teva Pharmaceuticals USA), VALSARTAN (Torrent Pharmaceuticals Limited)
Formula
C24H29N5O3
Exact mass
435.227
Mol weight
435.5188
Structure
Mol fileKCF fileDB searchJmolKegDraw
Class
Cardiovascular agent
 DG01495  Angiotensin II receptor antagonist
Unclassified
 DG01925  Renin-angiotensin system inhibitor
  DG01495  Angiotensin II receptor antagonist
Remark
Therapeutic category: 
ATC code: 
Activity
Antihypertensive, Angiotensin II receptor antagonist
Target
angiotensin II receptor type 1 (AT1) [HSA:185] [KO:K04166]
  Pathway
Calcium signaling pathway
Neuroactive ligand-receptor interaction
Vascular smooth muscle contraction
Renin-angiotensin system
Metabolism
Enzyme: CYP2C9 [HSA:1559]
Transporter: SLCO1B1 [HSA:10599], SLCO1B3 [HSA:28234], ABCC2 [HSA:1244]
Interaction
Drug interaction
Structure map
Angiotensin receptor and endothelin receptor antagonists
Other map
Bile secretion
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 C CARDIOVASCULAR SYSTEM
  C09 AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM
   C09C ANGIOTENSIN II ANTAGONISTS, PLAIN
    C09CA Angiotensin II antagonists, plain
     C09CA03 Valsartan
      D00400  Valsartan (JP17/USAN/INN)
USP drug classification [BR:br08302]
 Cardiovascular Agents
  Angiotensin II Receptor Antagonists
   Valsartan
    D00400  Valsartan (JP17/USAN/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  21  Cardiovascular agents
   214  Antihypertensives
    2149  Others
     D00400  Valsartan (JP17/USAN/INN)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Angiotensin
    angiotensin II stimulates angiotensin subtype 1 (AT1) receptor
     Valsartan
      D00400  Valsartan (JP17/USAN/INN)
Cytochrome P450 interactions [BR:br08309]
 CYP inhbitors
  CYP3A
   Valsartan
    D00400  Valsartan (JP17/USAN/INN)
 CYP substrates
  CYP2C9
   Valsartan
    D00400  Valsartan (JP17/USAN/INN)
 Transporter substrates
  ABCC2
   Valsartan
    D00400  Valsartan (JP17/USAN/INN)
  SLCO1B1
   Valsartan
    D00400  Valsartan (JP17/USAN/INN)
  SLCO1B3
   Valsartan
    D00400  Valsartan (JP17/USAN/INN)
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D00400  Valsartan
  D00400  Valsartan tablets
Cardiovascular agents [br08364.html]
 Antihypertensives
  D00400
BRITE hierarchy
Other DBs
CAS: 
137862-53-4
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        32
            1   C8x C    19.4226  -22.2154
            2   C8x C    19.4226  -23.6234
            3   C8x C    20.6194  -24.3274
            4   C8x C    21.8865  -23.6234
            5   C8y C    21.8865  -22.2154
            6   C8y C    20.6194  -21.5115
            7   C8y C    23.0833  -21.5115
            8   C8x C    24.2801  -22.2154
            9   C8x C    25.5472  -21.5115
            10  C8y C    25.5472  -20.1035
            11  C8x C    24.3504  -19.3995
            12  C8x C    23.0833  -20.1035
            13  C8y C    20.6194  -20.1035
            14  N4x N    21.7457  -19.2587
            15  N5x N    21.3233  -17.9916
            16  N5x N    19.9154  -17.9916
            17  N5x N    19.4930  -19.2587
            18  C1b C    26.7440  -19.3995
            19  N1c N    26.7440  -17.9916
            20  C1c C    27.9407  -17.2876
            21  C5a C    25.5472  -17.2876
            22  O5a O    24.3504  -17.9916
            23  C1b C    25.5472  -15.8797
            24  C1b C    24.3504  -15.1757
            25  C1b C    24.3504  -13.7677
            26  C1a C    23.1537  -13.0637
            27  C6a C    29.1375  -17.9916
            28  O6a O    30.3343  -17.2876
            29  O6a O    29.1375  -19.3995
            30  C1c C    27.9407  -15.8797
            31  C1a C    26.7440  -15.1757
            32  C1a C    29.1375  -15.1757
BOND        34
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     5   7 1
            8     7   8 2
            9     8   9 1
            10    9  10 2
            11   10  11 1
            12   11  12 2
            13    7  12 1
            14    6  13 1
            15   13  14 1
            16   14  15 1
            17   15  16 2
            18   16  17 1
            19   13  17 2
            20   10  18 1
            21   18  19 1
            22   19  20 1
            23   19  21 1
            24   21  22 2
            25   21  23 1
            26   23  24 1
            27   24  25 1
            28   25  26 1
            29   20  27 1
            30   27  28 2
            31   27  29 1
            32   20  30 1 #Up
            33   30  31 1
            34   30  32 1

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