KEGG   DRUG: D00401Help
Entry
D00401                      Drug                                   

Name
Thiamazole (JP16/INN);
Methimazole (USP);
Tapazole (TN)
Product
  Generic
METHIMAZOLE (American Health Packaging), METHIMAZOLE (Boca Pharmacal), METHIMAZOLE (Bryant Ranch Prepack), METHIMAZOLE (Dispensing Solutions), METHIMAZOLE (Eon Labs), METHIMAZOLE (Exact-Rx), METHIMAZOLE (Golden State Medical Supply), METHIMAZOLE (Heritage Pharmaceuticals), METHIMAZOLE (NCS HealthCare of KY), METHIMAZOLE (Par Pharmaceutical), TAPAZOLE (Pfizer Laboratories Div Pfizer), METHIMAZOLE (Physicians Total Care), METHIMAZOLE (Preferred Pharmaceuticals), METHIMAZOLE (REMEDYREPACK), TAPAZOLE (REMEDYREPACK), TAPAZOLE (REMEDYREPACK), METHIMAZOLE (REMEDYREPACK), METHIMAZOLE (REMEDYREPACK), METHIMAZOLE (REMEDYREPACK), METHIMAZOLE (Rebel Distributors Corp.), METHIMAZOLE (State of Florida DOH Central Pharmacy), METHIMAZOLE (State of Florida DOH Central Pharmacy), METHIMAZOLE (State of Florida DOH Central Pharmacy), METHIMAZOLE (Unit Dose Services)
Formula
C4H6N2S
Exact mass
114.0252
Mol weight
114.1688
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Thyroid inhibitor [DS:H00082]
Remark
Same as: 
Therapeutic category: 
ATC code: 
Target
thyroid peroxidase inhibitor [HSA:7173] [KO:K00431]
  Pathway
hsa00350  Tyrosine metabolism
hsa04060  Cytokine-cytokine receptor interaction
hsa04630  Jak-STAT signaling pathway
hsa05320  Autoimmune thyroid disease  
 
Interaction
Drug interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 H SYSTEMIC HORMONAL PREPARATIONS, EXCL. SEX HORMONES AND INSULINS
  H03 THYROID THERAPY
   H03B ANTITHYROID PREPARATIONS
    H03BB Sulfur-containing imidazole derivatives
     H03BB02 Thiamazole
      D00401  Thiamazole (JP16/INN); Methimazole (USP)
USP drug classification [BR:br08302]
 Hormonal Agents, Suppressant (Thyroid)
  Antithyroid Agents
   Methimazole
    D00401  Thiamazole (JP16/INN); Methimazole (USP)
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  24  Hormones
   243  Thyroid and parathyroid hormone preparations
    2432  Antithyroid hormones
     D00401  Thiamazole (JP16/INN); Methimazole (USP)
Target-based classification of drugs [BR:br08310]
 Enzymes
  Oxidoreductases
   thyroid peroxidase
    Thiamazole
     D00401  Thiamazole (JP16/INN); Methimazole (USP)
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D00401  Thiamazole
  D00401  Thiamazole tablets
BRITE hierarchy
Other DBs
CAS: 
60-56-0
PubChem: 
DrugBank: 
PDB-CCD: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        7
            1   C8y C    26.1871  -18.2805
            2   N4y N    25.7487  -19.6075
            3   N4x N    25.0529  -17.4502
            4   S0  S    27.5142  -17.8478
            5   C8x C    24.3513  -19.6075
            6   C1a C    26.5730  -20.7418
            7   C8x C    23.9186  -18.2805
BOND        7
            1     1   2 1
            2     1   3 1
            3     1   4 2
            4     2   5 1
            5     2   6 1
            6     3   7 1
            7     5   7 2

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