KEGG   DRUG: D00401Help
Entry
D00401                      Drug                                   

Name
Thiamazole (JP16/INN);
Methimazole (USP);
Tapazole (TN)
Product
  Generic
Formula
C4H6N2S
Exact mass
114.0252
Mol weight
114.1688
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Thyroid inhibitor [DS:H00082]
Remark
Same as: 
Therapeutic category: 
ATC code: 
Target
thyroid peroxidase inhibitor [HSA:7173] [KO:K00431]
  Pathway
hsa00350  Tyrosine metabolism
hsa04060  Cytokine-cytokine receptor interaction
hsa04630  Jak-STAT signaling pathway
hsa05320  Autoimmune thyroid disease  
 
Interaction
Drug interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 H SYSTEMIC HORMONAL PREPARATIONS, EXCL. SEX HORMONES AND INSULINS
  H03 THYROID THERAPY
   H03B ANTITHYROID PREPARATIONS
    H03BB Sulfur-containing imidazole derivatives
     H03BB02 Thiamazole
      D00401  Thiamazole (JP16/INN); Methimazole (USP)
USP drug classification [BR:br08302]
 Hormonal Agents, Suppressant (Thyroid)
  Antithyroid Agents
   Methimazole
    D00401  Thiamazole (JP16/INN); Methimazole (USP)
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  24  Hormones
   243  Thyroid and parathyroid hormone preparations
    2432  Antithyroid hormones
     D00401  Thiamazole (JP16/INN); Methimazole (USP)
Target-based classification of drugs [BR:br08310]
 Enzymes
  Oxidoreductases
   thyroid peroxidase
    Thiamazole
     D00401  Thiamazole (JP16/INN); Methimazole (USP)
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D00401  Thiamazole
  D00401  Thiamazole tablets
BRITE hierarchy
Other DBs
CAS: 
60-56-0
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        7
            1   C8y C    26.1871  -18.2805
            2   N4y N    25.7487  -19.6075
            3   N4x N    25.0529  -17.4502
            4   S0  S    27.5142  -17.8478
            5   C8x C    24.3513  -19.6075
            6   C1a C    26.5730  -20.7418
            7   C8x C    23.9186  -18.2805
BOND        7
            1     1   2 1
            2     1   3 1
            3     1   4 2
            4     2   5 1
            5     2   6 1
            6     3   7 1
            7     5   7 2

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