KEGG   DRUG: D00403Help
Entry
D00403                      Drug                                   

Name
Levomepromazine (USAN/INN);
Methotrimeprazine (USP);
Levoprome (TN)
Formula
C19H24N2OS
Exact mass
328.1609
Mol weight
328.4717
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Analgesic [central nervous system depressant]
Remark
Same as: 
ATC code: 
Target
5-HT2-receptor antagonist [HSA:3356 3357 3358] [KO:K04157];
alpha1-adrenergic receptor antagonist [HSA:146 147 148] [KO:K04137 K04136 K04135];
alpha2-adrenergic receptor antagonist [HSA:150 151 152] [KO:K04138 K04139 K04140];
dopamine D2-receptor antagonist [HSA:1813] [KO:K04145]
  Pathway
hsa04020  Calcium signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04726  Serotonergic synapse
hsa04728  Dopaminergic synapse  
 
Metabolism
Enzyme: CYP2D6 [HSA:1565]
Interaction
CYP inhibition: CYP2D6 [HSA:1565]
Drug interaction
Structure map
Phenothiazines
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N05 PSYCHOLEPTICS
   N05A ANTIPSYCHOTICS
    N05AA Phenothiazines with aliphatic side-chain
     N05AA02 Levomepromazine
      D00403  Levomepromazine (USAN/INN); Methotrimeprazine (USP)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Adrenaline
    alpha1-adrenergic receptor [HSA:146 147 148] [KO:K04137 K04136 K04135]
     Levomepromazine [ATC:N05AA02]
      D00403  Levomepromazine (USAN/INN); Methotrimeprazine (USP)
    alpha2-adrenergic receptor [HSA:150 151 152] [KO:K04138 K04139 K04140]
     Levomepromazine [ATC:N05AA02]
      D00403  Levomepromazine (USAN/INN); Methotrimeprazine (USP)
   Dopamine
    dopamine D2-receptor [HSA:1813] [KO:K04145]
     Levomepromazine [ATC:N05AA02]
      D00403  Levomepromazine (USAN/INN); Methotrimeprazine (USP)
   Serotonin
    5-HT2-receptor [HSA:3356 3357 3358] [KO:K04157]
     Levomepromazine [ATC:N05AA02]
      D00403  Levomepromazine (USAN/INN); Methotrimeprazine (USP)
BRITE hierarchy
Other DBs
CAS: 
60-99-1
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        23
            1   C8x C    20.8420  -21.1249
            2   C8x C    20.8420  -22.5291
            3   C8x C    22.1058  -23.2312
            4   C8x C    22.1058  -20.4228
            5   C8y C    23.2993  -21.1249
            6   C8y C    23.2993  -22.5291
            7   S2x S    24.4929  -23.2312
            8   N1y N    24.4929  -20.4228
            9   C8y C    25.6865  -21.1249
            10  C8y C    25.6865  -22.5291
            11  C8x C    26.8099  -23.2312
            12  C8x C    28.0737  -22.5291
            13  C8y C    28.0737  -21.1249
            14  C8x C    26.8801  -20.4228
            15  C1b C    24.4929  -19.0186
            16  C1c C    25.6865  -18.3165
            17  C1b C    25.6865  -16.9123
            18  C1a C    26.8801  -19.0186
            19  N1c N    26.8801  -16.2102
            20  C1a C    26.8801  -14.8060
            21  C1a C    28.1439  -16.9123
            22  O2a O    29.3374  -20.4228
            23  C1a C    30.5310  -21.1249
BOND        25
            1    14   9 1
            2     2   3 2
            3     5   6 2
            4     6   7 1
            5     8  15 1
            6     7  10 1
            7    15  16 1
            8     9   8 1
            9    16  17 1
            10    8   5 1
            11   16  18 1 #Up
            12    3   6 1
            13   17  19 1
            14    5   4 1
            15   19  20 1
            16    4   1 2
            17   19  21 1
            18    1   2 1
            19    9  10 2
            20   10  11 1
            21   11  12 2
            22   12  13 1
            23   13  14 2
            24   13  22 1
            25   22  23 1

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