KEGG   DRUG: ZidovudineHelp
Entry
D00413                      Drug                                   

Name
Zidovudine (JP17/USP/INN);
Retrovir (TN)
Product
  Generic
ZIDOVUDINE (A-S Medication Solutions), ZIDOVUDINE (American Health Packaging), ZIDOVUDINE (American Health Packaging), ZIDOVUDINE (Aurobindo Pharma Limited), ZIDOVUDINE (Aurobindo Pharma Limited), ZIDOVUDINE (Aurobindo Pharma Limited), ZIDOVUDINE (Boca Pharmacal), ZIDOVUDINE (Boca Pharmacal), ZIDOVUDINE (Bryant Ranch Prepack), ZIDOVUDINE (Camber Pharmaceuticals), ZIDOVUDINE (Cipla), ZIDOVUDINE (Cipla), ZIDOVUDINE (Cipla), ZIDOVUDINE (Citron Pharma LLC), ZIDOVUDINE (Edenbridge Pharmaceuticals), ZIDOVUDINE (Edenbridge Pharmaceuticals), ZIDOVUDINE (LUCID PHARMA LLC), ZIDOVUDINE (LUCID PHARMA LLC), ZIDOVUDINE (Lannett Company), ZIDOVUDINE (Mylan Pharmaceuticals), ZIDOVUDINE (REMEDYREPACK), ZIDOVUDINE (REMEDYREPACK), ZIDOVUDINE (REMEDYREPACK), ZIDOVUDINE (REMEDYREPACK), ZIDOVUDINE (REMEDYREPACK), ZIDOVUDINE (REMEDYREPACK), ZIDOVUDINE (REMEDYREPACK), ZIDOVUDINE (REMEDYREPACK), ZIDOVUDINE (REMEDYREPACK), ZIDOVUDINE (REMEDYREPACK), ZIDOVUDINE (Rebel Distributors Corp), ZIDOVUDINE (Roxane Laboratories), ZIDOVUDINE (State of Florida DOH Central Pharmacy)
Formula
C10H13N5O4
Exact mass
267.0968
Mol weight
267.2413
Structure
Mol fileKCF fileDB searchJmolKegDraw
Class
Antiviral
 DG01890  Nucleoside reverse transcriptase inhibitor
 DG01656  HIV reverse transcriptase inhibitor
Remark
Same as: 
Therapeutic category: 
ATC code: 
Activity
Antiviral, Reverse transcriptase inhibitor
  Disease
HIV infection [DS:H01563]
Comment
Nucleoside reverse transcriptase inhibitor (NRTI)
Zidovudine type
Target
RNA-directed DNA polymerase
Metabolism
Enzyme: UGT2B7 [HSA:7364]
Transporter: SLC22A6 [HSA:9356], SLC22A8 [HSA:9376]
Interaction
Drug interaction
Structure map
Antiviral agents
Anti-HIV agents
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 J ANTIINFECTIVES FOR SYSTEMIC USE
  J05 ANTIVIRALS FOR SYSTEMIC USE
   J05A DIRECT ACTING ANTIVIRALS
    J05AF Nucleoside and nucleotide reverse transcriptase inhibitors
     J05AF01 Zidovudine
      D00413  Zidovudine (JP17/USP/INN)
USP drug classification [BR:br08302]
 Antivirals
  Anti-HIV Agents, Nucleoside and Nucleotide Reverse Transcriptase Inhibitors (NRTI)v
   Zidovudine
    D00413  Zidovudine (JP17/USP/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 6  Agents against pathologic organisms and parasites
  62  Chemotherapeutics
   625  Antivirals
    6250  Antivirals
     D00413  Zidovudine (JP17/USP/INN)
Antiinfectives [BR:br08307]
 Antivirals
  Anti-HIV agents
   Reverse transcriptase inhibitor (RTI)
    Nucleoside and nucleotide reverse transcriptase inhibitor (NRTIs)
     Zidovudine
      D00413  Zidovudine (JP17/USP/INN)
Cytochrome P450 interactions [BR:br08309]
 Transporter substrates
  OAT1
   Zidovudine
    D00413  Zidovudine (JP17/USP/INN)
  OAT3
   Zidovudine
    D00413  Zidovudine (JP17/USP/INN)
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D00413  Zidovudine
Antivirals [br08351.html]
 D00413
Orphan drugs in the USA [br08355.html]
 Orphan drugs in the USA
  D00413
BRITE hierarchy
Other DBs
CAS: 
30516-87-1
PubChem: 
DrugBank: 
PDB-CCD: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        19
            1   C1y C    21.8892  -16.1997
            2   N4y N    23.5794  -15.4271
            3   C1x C    21.4499  -17.5090
            4   O2x O    20.7758  -15.3833
            5   C8y C    24.7119  -14.7808
            6   C8x C    22.3375  -14.8245
            7   C1y C    20.0762  -17.5044
            8   C1y C    19.6569  -16.1923
            9   N4x N    24.7212  -13.3441
            10  O5x O    25.9172  -15.4428
            11  C8y C    22.3030  -13.4511
            12  N2b N    19.2710  -18.6180
            13  C1b C    18.3417  -15.7702
            14  C8y C    23.4879  -12.7321
            15  C1a C    21.0666  -12.8501
            16  O1a O    17.3143  -16.6825
            17  O5x O    23.5292  -11.3605
            18  N0  N    18.3631  -19.6938 #+
            19  N2a N    17.3740  -20.8595 #-
BOND        20
            1     1   2 1 #Up
            2     1   3 1
            3     1   4 1
            4     2   5 1
            5     2   6 1
            6     3   7 1
            7     4   8 1
            8     5   9 1
            9     5  10 2
            10    6  11 2
            11    7  12 1 #Down
            12    8  13 1 #Up
            13    9  14 1
            14   11  15 1
            15   13  16 1
            16   14  17 2
            17    7   8 1
            18   11  14 1
            19   12  18 2
            20   18  19 2

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