KEGG   DRUG: D00415Help
Entry
D00415                      Drug                                   

Name
Zolmitriptan (JAN/USAN/INN);
Zomig (TN)
Product
  Generic
Formula
C16H21N3O2
Exact mass
287.1634
Mol weight
287.3568
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Antimigraine
Remark
Same as: 
Therapeutic category: 
ATC code: 
Target
5-HT1B-receptor agonist [HSA:3351] [KO:K04153];
5-HT1D-receptor agonist [HSA:3352] [KO:K04153]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04726  Serotonergic synapse  
 
Metabolism
Enzyme: CYP1A2 [HSA:1544], MAOA [HSA:4128]
Interaction
Drug interaction
Structure map
Antimigraines
Serotonin receptor agonists/antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N02 ANALGESICS
   N02C ANTIMIGRAINE PREPARATIONS
    N02CC Selective serotonin (5HT1) agonists
     N02CC03 Zolmitriptan
      D00415  Zolmitriptan (JAN/USAN/INN)
USP drug classification [BR:br08302]
 Antimigraine Agents
  Serotonin (5-HT) 1b/1d Receptor Agonists
   Zolmitriptan
    D00415  Zolmitriptan (JAN/USAN/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  21  Cardiovascular agents
   216  Vasoconstrictors
    2160  Vasoconstrictors
     D00415  Zolmitriptan (JAN/USAN/INN)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Serotonin
    5-HT1B-receptor
     Zolmitriptan
      D00415  Zolmitriptan (JAN/USAN/INN)
    5-HT1D-receptor
     Zolmitriptan
      D00415  Zolmitriptan (JAN/USAN/INN)
Cytochrome P450 interactions [BR:br08309]
 Substrates
  CYP1A2
   Zolmitriptan
    D00415  Zolmitriptan (JAN/USAN/INN)
BRITE hierarchy
Other DBs
CAS: 
139264-17-8
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        21
            1   C8y C    24.7800  -23.1700
            2   C8y C    24.7800  -24.5700
            3   C8y C    26.1800  -22.7500
            4   C8x C    23.5900  -22.4700
            5   N4x N    26.1800  -25.0600
            6   C8x C    23.5900  -25.2700
            7   C8x C    26.9500  -23.8700
            8   C1b C    26.6000  -21.4900
            9   C8y C    22.4000  -23.1700
            10  C8x C    22.4000  -24.6400
            11  C1b C    28.0000  -21.2100
            12  C1b C    21.1400  -22.4000
            13  N1c N    28.4200  -19.8800
            14  C1y C    19.9500  -23.1700
            15  C1a C    27.5800  -18.8300
            16  C1a C    29.8200  -19.6000
            17  N1x N    19.9500  -24.5000
            18  C1x C    18.6200  -22.6800
            19  C7x C    18.5500  -24.9200
            20  O7x O    17.7800  -23.8000
            21  O6a O    18.0600  -26.2500
BOND        23
            1     1   2 2
            2     1   3 1
            3     1   4 1
            4     2   5 1
            5     2   6 1
            6     3   7 2
            7     3   8 1
            8     4   9 2
            9     6  10 2
            10    8  11 1
            11    9  12 1
            12   11  13 1
            13   14  12 1 #Down
            14   13  15 1
            15   13  16 1
            16   14  17 1
            17   14  18 1
            18   17  19 1
            19   18  20 1
            20   19  21 2
            21    5   7 1
            22    9  10 1
            23   19  20 1

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