KEGG   DRUG: ZolmitriptanHelp
Entry
D00415                      Drug                                   

Name
Zolmitriptan (JAN/USAN/INN);
Zomig (TN)
Product
  Generic
ZOLMITRIPTAN (APPCO PHARMA LLC), ZOLMITRIPTAN (Ajanta Pharma Limited), ZOLMITRIPTAN (Alembic Pharmaceuticals Limited), ZOLMITRIPTAN (Alembic Pharmaceuticals Limited), ZOLMITRIPTAN (Apotex Corp), ZOLMITRIPTAN (Aurobindo Pharma Limited), ZOLMITRIPTAN (BluePoint Laboratories), ZOLMITRIPTAN (Cadila Healthcare Limited), ZOLMITRIPTAN (Camber Pharmaceuticals), ZOLMITRIPTAN (Cipla USA), ZOLMITRIPTAN (Glenmark Pharmaceuticals), ZOLMIPTRIPTAN (Glenmark Pharmaceuticals), ZOLMITRIPTAN (Jubilant Cadista Pharmaceuticals), ZOLMITRIPTAN OD (Jubilant Cadista Pharmaceuticals), ZOLMITRIPTAN (Macleods Pharmaceuticals Limited), ZOLMITRIPTAN (Mylan Pharmaceuticals), ZOLMITRIPTAN (PLD Acquisitions LLC DBA Avema Pharma Solutions), ZOLMITRIPTAN (Rising Pharmaceuticals), ZOLMITRIPTAN (Rising Pharmaceuticals), ZOLMITRIPTAN (Zydus Pharmaceuticals (USA))
Formula
C16H21N3O2
Exact mass
287.1634
Mol weight
287.3568
Structure
Mol fileKCF fileDB searchJmolKegDraw
Simcomp SIMCOMP
Class
Analgesic
 DG01484  5-HT1B-receptor agonist
 DG01485  5-HT1D-receptor agonist
 DG01518  5-HT1B/1D-receptor agonist
 DG01943  Triptan
Cyp substrate
 DG01892  CYP1A2 substrate
Remark
Same as: C07218
Therapeutic category: 2160
ATC code: N02CC03
Product: D00415<JP/US>
Efficacy
Antimigraine, Vasoconstrictor, Serotonin receptor agonist
Comment
Sumatriptan derivative
Target
HTR1B [HSA:3351] [KO:K04153]
HTR1D [HSA:3352] [KO:K04153]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04726  Serotonergic synapse
Metabolism
Enzyme: CYP1A2 [HSA:1544], MAOA [HSA:4128]
Interaction
Drug interaction
Structure map
map07048  Antimigraines
map07211  Serotonin receptor agonists/antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N02 ANALGESICS
   N02C ANTIMIGRAINE PREPARATIONS
    N02CC Selective serotonin (5HT1) agonists
     N02CC03 Zolmitriptan
      D00415  Zolmitriptan (JAN/USAN/INN) <JP/US>
USP drug classification [BR:br08302]
 Antimigraine Agents
  Serotonin (5-HT) 1b/1d Receptor Agonists
   Zolmitriptan
    D00415  Zolmitriptan (JAN/USAN/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  21  Cardiovascular agents
   216  Vasoconstrictors
    2160  Vasoconstrictors
     D00415  Zolmitriptan (JAN/USAN/INN)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Serotonin
    HTR1B
     D00415  Zolmitriptan (JAN/USAN/INN) <JP/US>
    HTR1D
     D00415  Zolmitriptan (JAN/USAN/INN) <JP/US>
Drug classes of therapeutic agents [br08360.html]
 Anesthetics, analgesics and anti-inflammatory drugs
  D00415
New drug approvals in Japan [br08318.html]
 Drugs with new active ingredients
  D00415
BRITE hierarchy
Other DBs
CAS: 139264-17-8
PubChem: 7847481
ChEBI: 10124
ChEMBL: CHEMBL1185
DrugBank: DB00315
LigandBox: D00415
NIKKAJI: J694.097H
KCF data Show

ATOM        21
            1   C8y C    24.7800  -23.1700
            2   C8y C    24.7800  -24.5700
            3   C8y C    26.1800  -22.7500
            4   C8x C    23.5900  -22.4700
            5   N4x N    26.1800  -25.0600
            6   C8x C    23.5900  -25.2700
            7   C8x C    26.9500  -23.8700
            8   C1b C    26.6000  -21.4900
            9   C8y C    22.4000  -23.1700
            10  C8x C    22.4000  -24.6400
            11  C1b C    28.0000  -21.2100
            12  C1b C    21.1400  -22.4000
            13  N1c N    28.4200  -19.8800
            14  C1y C    19.9500  -23.1700
            15  C1a C    27.5800  -18.8300
            16  C1a C    29.8200  -19.6000
            17  N1x N    19.9500  -24.5000
            18  C1x C    18.6200  -22.6800
            19  C7x C    18.5500  -24.9200
            20  O7x O    17.7800  -23.8000
            21  O6a O    18.0600  -26.2500
BOND        23
            1     1   2 2
            2     1   3 1
            3     1   4 1
            4     2   5 1
            5     2   6 1
            6     3   7 2
            7     3   8 1
            8     4   9 2
            9     6  10 2
            10    8  11 1
            11    9  12 1
            12   11  13 1
            13   14  12 1 #Down
            14   13  15 1
            15   13  16 1
            16   14  17 1
            17   14  18 1
            18   17  19 1
            19   18  20 1
            20   19  21 2
            21    5   7 1
            22    9  10 1
            23   19  20 1

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