KEGG   DRUG: Mitotane
Entry
D00420                      Drug                                   
Name
Mitotane (JAN/USP/INN);
Lysodren (TN)
Product
LYSODREN (HRA Pharma Rare Diseases)
Formula
C14H10Cl4
Exact mass
317.9537
Mol weight
320.0412
Structure
Simcomp
Remark
Therapeutic category: 2499
ATC code: L01XX23
Product: D00420<JP/US>
Efficacy
Antineoplastic, Steroid biosynthesis inhibitor
  Disease
Adrenal cortical carcinoma [DS:H00033]
Target
CYP17A1 [HSA:1586] [KO:K00512]
  Pathway
hsa00140  Steroid hormone biosynthesis
hsa04934  Cushing syndrome
  Network
nt06310  CRH-ACTH-cortisol signaling
Interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 L ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
  L01 ANTINEOPLASTIC AGENTS
   L01X OTHER ANTINEOPLASTIC AGENTS
    L01XX Other antineoplastic agents
     L01XX23 Mitotane
      D00420  Mitotane (JAN/USP/INN) <JP/US>
USP drug classification [BR:br08302]
 Antineoplastics
  Antineoplastics, Other
   Mitotane
    D00420  Mitotane (JAN/USP/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  24  Hormones
   249  Miscellaneous
    2499  Others
     D00420  Mitotane (JAN/USP/INN)
Target-based classification of drugs [BR:br08310]
 Enzymes
  Oxidoreductases (EC1)
   Cytochrome P450
    CYP17A1
     D00420  Mitotane (JAN/USP/INN) <JP/US>
New drug approvals in Europe [br08329.html]
 European public assessment reports (EPAR) authorised medicine
  D00420
Other DBs
CAS: 53-19-0
PubChem: 7847486
ChEBI: 6954
LigandBox: D00420
NIKKAJI: J1.366H
KCF data

ATOM        18
            1   C8x C     8.6800  -15.2600
            2   C8x C     8.6800  -16.6600
            3   C8x C     9.8924  -17.3600
            4   C8x C    11.1049  -16.6600
            5   C8y C    11.1049  -15.2600
            6   C8y C     9.8924  -14.5600
            7   C8x C    13.5297  -16.6600
            8   C8y C    13.5297  -15.2600
            9   C1c C    12.3173  -14.5600
            10  C8x C    14.7422  -17.3600
            11  C8y C    15.9546  -16.6600
            12  C8x C    15.9546  -15.2600
            13  C8x C    14.7422  -14.5600
            14  X   Cl    9.8924  -13.1602
            15  C1c C    12.3173  -13.1600
            16  X   Cl   13.5318  -12.4588
            17  X   Cl   11.1069  -12.4612
            18  X   Cl   17.1711  -17.3623
BOND        19
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     7   8 1
            8     8   9 1
            9     5   9 1
            10    7  10 2
            11   10  11 1
            12   11  12 2
            13   12  13 1
            14    8  13 2
            15    6  14 1
            16    9  15 1
            17   15  16 1
            18   15  17 1
            19   11  18 1

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Ontology (5)   
   KEGG BRITE (5)   
Disease (2)   
   KEGG DISEASE (2)   
Drug (2)   
   LigandBox (1)   
   SIDER (1)   
Chemical substance (5)   
   PubChem (1)   
   ChEBI (1)   
   HMDB (1)   
   HSDB (1)   
   NIKKAJI (1)   
Gene (2)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (1)   
All databases (16)   

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