KEGG   DRUG: RifabutinHelp
Entry
D00424                      Drug                                   

Name
Rifabutin (JAN/USP/INN);
Mycobutin (TN)
Product
  Generic
Formula
C46H62N4O11
Exact mass
846.4415
Mol weight
847.0047
Structure
Mol fileKCF fileDB searchJmolKegDraw
Class
Antibacterial
 DG01598  Rifamycin antibiotic
Cyp substrate
 DG01633  CYP3A substrate
Cyp inducer
 DG01635  CYP3A4 inducer
 DG01897  CYP3A5 inducer
Unclassified
Remark
Same as: 
Therapeutic category: 
ATC code: 
Activity
Antibacterial (antimycobacterial), RNA polymerase inhibitor
Comment
Rifamycin derivative
Target
DNA-dependent RNA polymerase
Metabolism
Enzyme: CYP3A4 [HSA:1576]
Interaction
CYP induction: CYP3A4 [HSA:1576], CYP3A5 [HSA:1577], CYP3A7 [HSA:1551]
Drug interaction
Structure map
Rifamycins
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 J ANTIINFECTIVES FOR SYSTEMIC USE
  J04 ANTIMYCOBACTERIALS
   J04A DRUGS FOR TREATMENT OF TUBERCULOSIS
    J04AB Antibiotics
     J04AB04 Rifabutin
      D00424  Rifabutin (JAN/USP/INN)
USP drug classification [BR:br08302]
 Antimycobacterials
  Antimycobacterials, Other
   Rifabutin
    D00424  Rifabutin (JAN/USP/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 6  Agents against pathologic organisms and parasites
  61  Antibiotics
   616  Acting mainly on acid-fast bacteria
    6169  Others
     D00424  Rifabutin (JAN/USP/INN)
Antiinfectives [BR:br08307]
 Antibacterials
  Nucleic acid synthesis inhibitor
   RNA polymerase inhibitor
    Rifamycins
     Rifabutin
      D00424  Rifabutin (JAN/USP/INN)
Cytochrome P450 interactions [BR:br08309]
 CYP inducers
  CYP2C19
   Rifabutin
    D00424  Rifabutin (JAN/USP/INN)
  CYP3A4
   Rifabutin
    D00424  Rifabutin (JAN/USP/INN)
  CYP3A5
   Rifabutin
    D00424  Rifabutin (JAN/USP/INN)
  CYP3A7
   Rifabutin
    D00424  Rifabutin (JAN/USP/INN)
  CYP3A
   Rifabutin
    D00424  Rifabutin (JAN/USP/INN)
 CYP substrates
  CYP3A4
   Rifabutin
    D00424  Rifabutin (JAN/USP/INN)
Antibacterials [br08350.html]
 D00424
New drug approvals in Japan [br08318.html]
 Drugs with new active ingredients
  D00424
Orphan drugs in the USA [br08355.html]
 Orphan drugs in the USA
  D00424
BRITE hierarchy
Other DBs
CAS: 
72559-06-9
PubChem: 
DrugBank: 
PDB-CCD: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        61
            1   C1c C    21.8400   -4.9000
            2   C1c C    21.8400   -6.3700
            3   O1a O    24.2900   -6.3000
            4   C1c C    24.2900   -4.9000
            5   C1c C    23.0300   -4.2000
            6   C2b C    26.6700   -4.9000
            7   C1c C    25.4800   -4.2000
            8   C5a C    27.9300   -7.0700
            9   C2c C    29.1200   -6.3700
            10  C2b C    29.1200   -4.9000
            11  C2b C    27.9300   -4.2000
            12  C1a C    25.4800   -2.8000
            13  C1a C    23.0300   -2.8000
            14  O1a O    20.6500   -4.2000
            15  C1a C    30.3100   -7.0700
            16  O5a O    26.7400   -6.3700
            17  N1b N    27.9300   -8.7500
            18  C1c C    20.6500   -7.0700
            19  O7a O    19.4600   -6.3700
            20  C1c C    20.6500   -8.7500
            21  C2y C    26.7400   -9.4500
            22  C2y C    26.7400  -10.8500
            23  C5x C    25.4800   -8.7500
            24  C8y C    24.2900   -9.4500
            25  C8y C    24.2900  -10.8500
            26  C2y C    25.4800  -11.5500
            27  C8y C    23.1000   -8.7500
            28  C8y C    21.8400   -9.4500
            29  C8y C    21.8400  -10.8500
            30  C8y C    23.1000  -11.5500
            31  O5x O    25.4800   -7.3500
            32  O1a O    23.1000   -7.3500
            33  C1a C    20.6500   -5.2500
            34  C7a C    18.2000   -5.6700
            35  C1a C    17.0100   -6.3700
            36  O6a O    18.2000   -4.2700
            37  N2x N    25.4800  -12.9500
            38  C1z C    28.0000  -12.9500
            39  N1x N    28.0000  -11.5500
            40  C1x C    28.0000  -14.3500
            41  C1x C    29.2124  -15.0500
            42  N1y N    30.4249  -14.3500
            43  C1x C    30.4249  -12.9500
            44  C1x C    29.2124  -12.2500
            45  C1b C    31.6560  -15.0610
            46  C1c C    32.8612  -14.3653
            47  C1a C    34.0435  -15.0481
            48  C1a C    32.8616  -12.9504
            49  C1c C    19.4376   -9.4500
            50  O2a O    18.2421   -8.7596
            51  C2b C    19.4375  -10.8498
            52  C1a C    19.4376   -7.7700
            53  C1a C    17.0547   -9.4451
            54  C2b C    18.2419  -11.5402
            55  O2a O    18.2419  -12.9402
            56  O2x O    20.6334  -11.5600
            57  C1z C    20.6334  -12.9600
            58  C5x C    23.1000  -12.9500
            59  O5x O    24.0919  -13.9379
            60  C1a C    20.6334  -14.3600
            61  C1a C    21.8400   -8.0500
BOND        66
            1     1   2 1
            2     4   3 1 #Down
            3     4   5 1
            4     1   5 1
            5     6   7 1
            6     4   7 1
            7     8   9 1
            8     9  10 2
            9    10  11 1
            10    6  11 2
            11    7  12 1 #Up
            12    5  13 1 #Down
            13    1  14 1 #Down
            14    9  15 1
            15    8  16 2
            16    8  17 1
            17    2  18 1
            18   18  19 1 #Up
            19   18  20 1
            20   17  21 1
            21   21  22 2
            22   21  23 1
            23   23  24 1
            24   24  25 1
            25   25  26 1
            26   24  27 2
            27   27  28 1
            28   28  29 2
            29   29  30 1
            30   25  30 2
            31   23  31 2
            32   27  32 1
            33    2  33 1 #Up
            34   19  34 1
            35   34  35 1
            36   34  36 2
            37   37  38 1
            38   38  39 1
            39   39  22 1
            40   26  37 2
            41   26  22 1
            42   38  40 1
            43   40  41 1
            44   41  42 1
            45   42  43 1
            46   43  44 1
            47   38  44 1
            48   42  45 1
            49   45  46 1
            50   46  47 1
            51   46  48 1
            52   20  49 1
            53   49  50 1 #Down
            54   49  51 1
            55   20  52 1 #Down
            56   50  53 1
            57   51  54 2
            58   54  55 1
            59   29  56 1
            60   56  57 1
            61   55  57 1
            62   30  58 1
            63   57  58 1
            64   58  59 2
            65   57  60 1 #Down
            66   28  61 1

» Japanese version   » Back

DBGET integrated database retrieval system