KEGG   DRUG: D00431Help
Entry
D00431                      Drug                                   

Name
Metolazone (JAN/USP/INN);
Zaroxolyn (TN)
Product
  Generic
Formula
C16H16ClN3O3S
Exact mass
365.0601
Mol weight
365.8345
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Diuretic;
Antihypertensive
Remark
ATC code: 
Target
Na+-Cl- symport inhibitor [HSA:6559] [KO:K14426]
Interaction
Drug interaction
Structure map
Sulfonamide derivatives - diuretics
Ion transporter inhibitors
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 C CARDIOVASCULAR SYSTEM
  C03 DIURETICS
   C03B LOW-CEILING DIURETICS, EXCL. THIAZIDES
    C03BA Sulfonamides, plain
     C03BA08 Metolazone
      D00431  Metolazone (JAN/USP/INN)
USP drug classification [BR:br08302]
 Cardiovascular Agents
  Diuretics, Thiazide
   Metolazone
    D00431  Metolazone (JAN/USP/INN)
Target-based classification of drugs [BR:br08310]
 Transporters
  Solute carrier family
   SLC12
    SLC12A3
     Metolazone
      D00431  Metolazone (JAN/USP/INN)
BRITE hierarchy
Other DBs
CAS: 
17560-51-9
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        24
            1   C8y C    22.2608  -17.1556
            2   C8y C    22.2434  -18.5423
            3   C5x C    23.4727  -16.4797
            4   C8x C    21.0664  -16.4448
            5   N1x N    23.4319  -19.2532
            6   C8x C    21.0256  -19.2299
            7   N1y N    24.6613  -17.1906
            8   O5x O    23.4260  -15.0871
            9   C8y C    19.7786  -17.1206
            10  C1y C    24.6439  -18.5773
            11  C8y C    19.8312  -18.5190
            12  C8y C    25.8791  -16.5147
            13  S4a S    18.6542  -16.4040
            14  C1a C    25.8384  -19.2939
            15  X   Cl   18.6134  -19.1949
            16  C8y C    25.8908  -15.1221
            17  C8x C    27.0676  -17.2313
            18  N1a N    17.5123  -15.6699
            19  O3c O    19.4933  -15.2444
            20  O3c O    17.7220  -17.7091
            21  C8x C    27.1085  -14.4462
            22  C1a C    24.6904  -14.4112
            23  C8x C    28.2854  -16.5554
            24  C8x C    28.3087  -15.1570
BOND        26
            1     1   2 2
            2     1   3 1
            3     1   4 1
            4     2   5 1
            5     2   6 1
            6     3   7 1
            7     3   8 2
            8     4   9 2
            9     5  10 1
            10    6  11 2
            11    7  12 1
            12    9  13 1
            13   10  14 1
            14   11  15 1
            15   12  16 1
            16   12  17 2
            17   13  18 1
            18   13  19 2
            19   13  20 2
            20   16  21 2
            21   16  22 1
            22   17  23 1
            23   21  24 1
            24    7  10 1
            25    9  11 1
            26   23  24 2

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