KEGG   DRUG: NadololHelp
Entry
D00432                      Drug                                   

Name
Nadolol (JP17/USP/INN);
Corgard (TN)
Product
  Generic
Formula
C17H27NO4
Exact mass
309.194
Mol weight
309.4006
Structure
Mol fileKCF fileDB searchJmolKegDraw
Class
Cardiovascular agent
 DG01653  Antiarrhythmics
  DG01806  Class II antiarrhythmic agent
 DG01466  Adrenergic receptor antagonist
  DG01464  beta-Adrenergic receptor antagonist
   DG01461  beta1-Adrenergic receptor antagonist
   DG01462  beta2-Adrenergic receptor antagonist
   DG01463  beta3-Adrenergic receptor antagonist
Remark
Therapeutic category: 
ATC code: 
Activity
Anti-adrenergic [beta-receptor]
Target
beta1-adrenergic receptor antagonist [HSA:153] [KO:K04141];
beta2-adrenergic receptor antagonist [HSA:154] [KO:K04142];
beta3-adrenergic receptor antagonist [HSA:155] [KO:K04143]
  Pathway
Calcium signaling pathway
Neuroactive ligand-receptor interaction
Adrenergic signaling in cardiomyocytes
Salivary secretion
Interaction
Drug interaction
Structure map
Antimigraines
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 C CARDIOVASCULAR SYSTEM
  C07 BETA BLOCKING AGENTS
   C07A BETA BLOCKING AGENTS
    C07AA Beta blocking agents, non-selective
     C07AA12 Nadolol
      D00432  Nadolol (JP17/USP/INN)
USP drug classification [BR:br08302]
 Cardiovascular Agents
  Beta-adrenergic Blocking Agents
   Nadolol
    D00432  Nadolol (JP17/USP/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  21  Cardiovascular agents
   212  Antiarrhythmic agents
    2123  Beta blockers
     D00432  Nadolol (JP17/USP/INN)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Adrenaline
    beta1-adrenergic receptor
     Nadolol
      D00432  Nadolol (JP17/USP/INN)
    beta2-adrenergic receptor
     Nadolol
      D00432  Nadolol (JP17/USP/INN)
    beta3-adrenergic receptor
     Nadolol
      D00432  Nadolol (JP17/USP/INN)
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D00432  Nadolol
Cardiovascular agents [br08364.html]
 Antihypertensives
  D00432
 Antiarrhythmics
  D00432
BRITE hierarchy
Other DBs
CAS: 
42200-33-9
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        22
            1   O2a O    25.1300  -25.3400
            2   C1b C    26.3200  -24.6400
            3   C1c C    27.5800  -25.3400
            4   C1b C    28.7700  -24.6400
            5   O1a O    27.5800  -26.8100
            6   N1b N    29.9600  -25.3400
            7   C1d C    31.2200  -24.6400
            8   C1a C    32.4800  -25.3400
            9   C1a C    31.2200  -23.4500
            10  C1a C    32.4800  -23.9400
            11  C8y C    25.1300  -26.7400
            12  C8y C    23.9400  -27.4400
            13  C8y C    23.9400  -28.8400
            14  C8x C    25.1300  -29.5400
            15  C8x C    26.3200  -28.8400
            16  C8x C    26.3200  -27.4400
            17  C1x C    22.7276  -26.7400
            18  C1y C    21.5151  -27.4400
            19  C1y C    21.5151  -28.8400
            20  C1x C    22.7276  -29.5400
            21  O1a O    20.2840  -26.7290
            22  O1a O    20.2840  -29.5510
BOND        23
            1     1   2 1
            2     2   3 1
            3     3   4 1
            4     3   5 1
            5     4   6 1
            6     6   7 1
            7     7   8 1
            8     7   9 1
            9     7  10 1
            10    1  11 1
            11   11  12 2
            12   12  13 1
            13   13  14 2
            14   14  15 1
            15   15  16 2
            16   11  16 1
            17   12  17 1
            18   17  18 1
            19   18  19 1
            20   19  20 1
            21   13  20 1
            22   18  21 1 #Up
            23   19  22 1 #Up

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