KEGG   DRUG: D00432Help
Entry
D00432                      Drug                                   

Name
Nadolol (JP16/USP/INN);
Corgard (TN)
Product
  Generic
Formula
C17H27NO4
Exact mass
309.194
Mol weight
309.4006
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Anti-adrenergic [beta-receptor]
Remark
Therapeutic category: 
ATC code: 
Drug group: 
Target
beta1-adrenergic receptor antagonist [HSA:153] [KO:K04141];
beta2-adrenergic receptor antagonist [HSA:154] [KO:K04142];
beta3-adrenergic receptor antagonist [HSA:155] [KO:K04143]
  Pathway
hsa04020  Calcium signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04261  Adrenergic signaling in cardiomyocytes
hsa04970  Salivary secretion  
 
Interaction
Drug interaction
Structure map
Antimigraines
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 C CARDIOVASCULAR SYSTEM
  C07 BETA BLOCKING AGENTS
   C07A BETA BLOCKING AGENTS
    C07AA Beta blocking agents, non-selective
     C07AA12 Nadolol
      D00432  Nadolol (JP16/USP/INN)
USP drug classification [BR:br08302]
 Cardiovascular Agents
  Beta-adrenergic Blocking Agents
   Nadolol
    D00432  Nadolol (JP16/USP/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  21  Cardiovascular agents
   212  Antiarrhythmic agents
    2123  Beta blockers
     D00432  Nadolol (JP16/USP/INN)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Adrenaline
    beta1-adrenergic receptor
     Nadolol
      D00432  Nadolol (JP16/USP/INN)
    beta2-adrenergic receptor
     Nadolol
      D00432  Nadolol (JP16/USP/INN)
    beta3-adrenergic receptor
     Nadolol
      D00432  Nadolol (JP16/USP/INN)
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D00432  Nadolol
BRITE hierarchy
Other DBs
CAS: 
42200-33-9
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        22
            1   O2a O    25.1300  -25.3400
            2   C1b C    26.3200  -24.6400
            3   C1c C    27.5800  -25.3400
            4   C1b C    28.7700  -24.6400
            5   O1a O    27.5800  -26.8100
            6   N1b N    29.9600  -25.3400
            7   C1d C    31.2200  -24.6400
            8   C1a C    32.4800  -25.3400
            9   C1a C    31.2200  -23.4500
            10  C1a C    32.4800  -23.9400
            11  C8y C    25.1300  -26.7400
            12  C8y C    23.9400  -27.4400
            13  C8y C    23.9400  -28.8400
            14  C8x C    25.1300  -29.5400
            15  C8x C    26.3200  -28.8400
            16  C8x C    26.3200  -27.4400
            17  C1x C    22.7276  -26.7400
            18  C1y C    21.5151  -27.4400
            19  C1y C    21.5151  -28.8400
            20  C1x C    22.7276  -29.5400
            21  O1a O    20.2840  -26.7290
            22  O1a O    20.2840  -29.5510
BOND        23
            1     1   2 1
            2     2   3 1
            3     3   4 1
            4     3   5 1
            5     4   6 1
            6     6   7 1
            7     7   8 1
            8     7   9 1
            9     7  10 1
            10    1  11 1
            11   11  12 2
            12   12  13 1
            13   13  14 2
            14   14  15 1
            15   15  16 2
            16   11  16 1
            17   12  17 1
            18   17  18 1
            19   18  19 1
            20   19  20 1
            21   13  20 1
            22   18  21 1 #Up
            23   19  22 1 #Up

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