KEGG   DRUG: SimvastatinHelp
Entry
D00434                      Drug                                   

Name
Simvastatin (JP17/USP/INN);
MK-733;
Zocor (TN)
Product
  Generic
SIMVASTATIN (A-S Medication Solutions), SIMVASTATIN (A-S Medication Solutions), SIMVASTATIN (A-S Medication Solutions), SIMVASTATIN (A-S Medication Solutions), SIMVASTATIN (Accord Healthcare), SIMVASTATIN (Aidarex Pharmaceuticals LLC), SIMVASTATIN (Aphena Pharma Solutions - Tennessee), SIMVASTATIN (Aphena Pharma Solutions - Tennessee), SIMVASTATIN (Aurobindo Pharma Limited), SIMVASTATIN (Aurolife Pharma LLC), SIMVASTATIN (AvPAK), SIMVASTATIN (Avera McKennan Hospital), SIMVASTATIN (Biocon Limited), SIMVASTATIN (Blenheim Pharmacal), SIMVASTATIN (Blenheim Pharmacal), SIMVASTATIN (Blu Pharmaceuticals), SIMVASTATIN (Blu Pharmceuticals LLC), SIMVASTATIN (Bryant Ranch Prepack), SIMVASTATIN (Bryant Ranch Prepack), SIMVASTATIN (Bryant Ranch Prepack), SIMVASTATIN (Bryant Ranch Prepack), SIMVASTATIN (Cadila Healthcare Limited), SIMVASTATIN (Camber Pharmaceuticals), SIMVASTATIN (Cardinal Health), SIMVASTATIN (Cardinal Health), SIMVASTATIN (Cardinal Health), SIMVASTATIN (Cardinal Health), SIMVASTATIN (Cardinal Health), SIMVASTATIN (Cardinal Health), SIMVASTATIN (Cardinal Health), SIMVASTATIN (Cardinal Health), SIMVASTATIN (Carilion Materials Management), SIMVASTATIN (Clinical Solutions Wholesale), SIMVASTATIN (Clinical Solutions Wholesale), SIMVASTATIN (Cobalt Laboratories), SIMVASTATIN (Cobalt Laboratories), SIMVASTATIN (Contract Pharmacy Services-PA), SIMVASTATIN (Contract Pharmacy Services-PA), SIMVASTATIN (DIRECT RX), SIMVASTATIN (Direct Rx), SIMVASTATIN (Dr. Reddy's Laboratories Limited), SIMVASTATIN (H.J. Harkins Company), SIMVASTATIN (H.J. Harkins Company), SIMVASTATIN (Ingenus Pharmaceuticals), SIMVASTATIN (International Laboratories), SIMVASTATIN (International Labs), SIMVASTATIN (KAISER FOUNDATION HOSPITALS), SIMVASTATIN (LUCID PHARMA LLC), SIMVASTATIN (LUPIN LIMITED), SIMVASTATIN (Lake Erie Medical & Surgical Supply DBA Quality Care Products LLC), SIMVASTATIN (Lake Erie Medical DBA Quality Care Products LLC), SIMVASTATIN (Lake Erie Medical DBA Quality Care Products LLC), SIMVASTATIN (Lake Erie Medical DBA Quality Care Products LLC), SIMVASTATIN (Legacy Pharmaceutical Packaging), SIMVASTATIN (Legacy Pharmaceutical Packaging), SIMVASTATIN (Legacy Pharmaceutical Packaging), SIMVASTATIN (Legacy Pharmaceutical Packaging), SIMVASTATIN (Life Line Home Care Services), SIMVASTATIN (Lupin Pharmaceuticals), SIMVASTATIN (Major Pharmaceuticals), SIMVASTATIN (McKesson Contract Packaging), SIMVASTATIN (McKesson Contract Packaging), SIMVASTATIN (McKesson Packaging Services a business unit of McKesson Corporation), SIMVASTATIN (McKesson Packaging Services a business unit of McKesson Corporation), SIMVASTATIN (MedVantx), SIMVASTATIN (MedVantx), SIMVASTATIN (MedVantx), SIMVASTATIN (Micro Labs Limited), SIMVASTATIN (Mylan Institutional), SIMVASTATIN (NCS HealthCare of KY), SIMVASTATIN (NCS HealthCare of KY), SIMVASTATIN (NorthStar Rx LLC), SIMVASTATIN (PD-Rx Pharmaceuticals), SIMVASTATIN (PD-Rx Pharmaceuticals), SIMVASTATIN (PD-Rx Pharmaceuticals), SIMVASTATIN (PD-Rx Pharmaceuticals), SIMVASTATIN (PD-Rx Pharmaceuticals), SIMVASTATIN (PD-Rx Pharmaceuticals), SIMVASTATIN (Physicians Total Care), SIMVASTATIN (Preferred Pharmaceuticals), SIMVASTATIN (Preferred Pharmaceuticals), SIMVASTATIN (Preferred Pharmaceuticals), SIMVASTATIN (Proficient Rx LP), SIMVASTATIN (REMEDYREPACK), SIMVASTATIN (REMEDYREPACK), SIMVASTATIN (REMEDYREPACK), SIMVASTATIN (REMEDYREPACK), SIMVASTATIN (REMEDYREPACK), SIMVASTATIN (REMEDYREPACK), SIMVASTATIN (REMEDYREPACK), SIMVASTATIN (REMEDYREPACK), SIMVASTATIN (REMEDYREPACK), SIMVASTATIN (REMEDYREPACK), SIMVASTATIN (REMEDYREPACK), SIMVASTATIN (REMEDYREPACK), SIMVASTATIN (REMEDYREPACK), SIMVASTATIN (REMEDYREPACK), SIMVASTATIN (REMEDYREPACK), SIMVASTATIN (REMEDYREPACK), SIMVASTATIN (REMEDYREPACK), SIMVASTATIN (REMEDYREPACK), SIMVASTATIN (REMEDYREPACK), SIMVASTATIN (REMEDYREPACK), SIMVASTATIN (REMEDYREPACK), SIMVASTATIN (REMEDYREPACK), SIMVASTATIN (Ranbaxy Pharmaceuticals), SIMVASTATIN (ReadyMeds), SIMVASTATIN (Rebel Distributors Corp), SIMVASTATIN (Rebel Distributors Corp), SIMVASTATIN (RxChange), SIMVASTATIN (RxChange), SIMVASTATIN (Safecor Health), SIMVASTATIN (St Marys Medical Park Pharmacy), SIMVASTATIN (St Marys Medical Park Pharmacy), SIMVASTATIN (State of Florida DOH Central Pharmacy), SIMVASTATIN (State of Florida DOH Central Pharmacy), SIMVASTATIN (State of Florida DOH Central Pharmacy), SIMVASTATIN (State of Florida DOH Central Pharmacy), SIMVASTATIN (State of Florida DOH Central Pharmacy), SIMVASTATIN (State of Florida DOH Central Pharmacy), SIMVASTATIN (Teva Pharmaceuticals USA), SIMVASTATIN (Unit Dose Services), SIMVASTATIN (Unit Dose Services), SIMVASTATIN (Unit Dose Services), SIMVASTATIN (Unit Dose Services), SIMVASTATIN (Unit Dose Services), SIMVASTATIN (Zydus Pharmaceuticals (USA))
Formula
C25H38O5
Exact mass
418.2719
Mol weight
418.5662
Structure
Mol fileKCF fileDB searchJmolKegDraw
Class
Cardiovascular agent
 DG01660  HMG-CoA reductase inhibitor
Cyp substrate
 DG01633  CYP3A4 substrate
Remark
Therapeutic category: 
ATC code: 
Activity
Antihyperlipidemic
Comment
mixture of Juvisync (TN)
prodrug
Target
hydroxymethylglutaryl coenzyme A (HMG-CoA) reductase inhibitor [HSA:3156] [KO:K00021]
  Pathway
Terpenoid backbone biosynthesis
Metabolism
Enzyme: CYP2C9 [HSA:1559], CYP3A4 [HSA:1576]
Interaction
Drug interaction
Structure map
HMG-CoA reductase inhibitors
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 C CARDIOVASCULAR SYSTEM
  C10 LIPID MODIFYING AGENTS
   C10A LIPID MODIFYING AGENTS, PLAIN
    C10AA HMG CoA reductase inhibitors
     C10AA01 Simvastatin
      D00434  Simvastatin (JP17/USP/INN)
USP drug classification [BR:br08302]
 Cardiovascular Agents
  Dyslipidemics, HMG CoA Reductase Inhibitors
   Simvastatin
    D00434  Simvastatin (JP17/USP/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  21  Cardiovascular agents
   218  Hyperlipidemia agents
    2189  Others
     D00434  Simvastatin (JP17/USP/INN)
Target-based classification of drugs [BR:br08310]
 Enzymes
  Oxidoreductases
   hydroxymethylglutaryl coenzyme A (HMG-CoA) reductase
    Simvastatin
     D00434  Simvastatin (JP17/USP/INN)
Cytochrome P450 interactions [BR:br08309]
 CYP substrates
  CYP2C9
   Simvastatin
    D00434  Simvastatin (JP17/USP/INN)
  CYP3A4
   Simvastatin
    D00434  Simvastatin (JP17/USP/INN)
  CYP3A
   Simvastatin
    D00434  Simvastatin (JP17/USP/INN)
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D00434  Simvastatin
  D00434  Simvastatin tablets
Hypolipidemic agents [br08365.html]
 D00434
BRITE hierarchy
Other DBs
CAS: 
79902-63-9
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        30
            1   C1y C    24.2376  -19.6357
            2   C1y C    23.0064  -18.9220
            3   C2y C    24.2317  -21.0573
            4   C1y C    25.4689  -18.9280
            5   O7a O    23.0064  -17.5005
            6   C1x C    21.7692  -19.6357
            7   C2x C    25.4569  -21.7772
            8   C2x C    23.0064  -21.7711
            9   C1b C    25.4749  -17.5063
            10  C1y C    26.7001  -19.6477
            11  C7a C    21.7751  -16.7867
            12  C1y C    21.7692  -21.0573
            13  C2x C    26.6943  -21.0693
            14  C1d C    20.5438  -17.5005
            15  O6a O    21.7811  -15.3649
            16  C1a C    20.5379  -21.7711
            17  C1b C    19.3125  -16.7867
            18  C1a C    21.0138  -18.4580
            19  C1a C    19.7985  -18.5280
            20  C1a C    18.0813  -17.4945
            21  C1a C    27.9276  -18.9468
            22  C1b C    26.6943  -16.8117
            23  C1y C    26.7328  -15.4070
            24  O7x O    27.9518  -14.6937
            25  C7x C    27.9436  -13.2891
            26  C1x C    26.7230  -12.5940
            27  C1y C    25.5509  -13.3074
            28  C1x C    25.5590  -14.7119
            29  O1a O    24.3194  -12.5926
            30  O6a O    29.1624  -12.5756
BOND        32
            1     1   2 1
            2     1   3 1
            3     1   4 1
            4     2   5 1 #Down
            5     2   6 1
            6     3   7 1
            7     3   8 2
            8     4   9 1 #Up
            9     4  10 1
            10    5  11 1
            11    6  12 1
            12    7  13 2
            13   11  14 1
            14   11  15 2
            15   12  16 1 #Down
            16   14  17 1
            17   14  18 1 #Down
            18   14  19 1 #Up
            19   17  20 1
            20    8  12 1
            21   10  13 1
            22   10  21 1 #Up
            23    9  22 1
            24   23  22 1 #Down
            25   23  24 1
            26   24  25 1
            27   25  26 1
            28   26  27 1
            29   27  28 1
            30   23  28 1
            31   27  29 1 #Up
            32   25  30 2

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