KEGG   DRUG: NevirapineHelp
Entry
D00435                      Drug                                   

Name
Nevirapine (JAN/USP/INN);
Viramune (TN)
Product
  Generic
NEVIRAPINE (Alvogen), NEVIRAPINE EXTENDED RELEASE (Alvogen), NEVIRAPINE (Amneal Pharmaceuticals of New York), NEVIRAPINE (Amneal-Agila), NEVIRAPINE (Apotex Corp), NEVIRAPINE (Aurobindo Pharma Limited), NEVIRAPINE (Aurobindo Pharma Limited), NEVIRAPINE (Aurobindo Pharma Limited), NEVIRAPINE (Aurobindo Pharma Limited), NEVIRAPINE (Breckenridge Pharmaceutical), NEVIRAPINE (Camber Pharmaceuticals), NEVIRAPINE (Carlsbad Technology), NEVIRAPINE (Cipla), NEVIRAPINE (Cipla USA), NEVIRAPINE (Golden State Medical Supply), NEVIRAPINE (Micro Labs Limited), NEVIRAPINE (Mylan Pharmaceuticals), NEVIRAPINE (Mylan Pharmaceuticals), NEVIRAPINE (Mylan Pharmaceuticals), NEVIRAPINE (Roxane Laboratories), NEVIRAPINE (Sandoz), NEVIRAPINE (State of Florida DOH Central Pharmacy), NEVIRAPINE (State of Florida DOH Central Pharmacy), NEVIRAPINE (Strides Shasun Limited)
Formula
C15H14N4O
Exact mass
266.1168
Mol weight
266.2979
Structure
Mol fileKCF fileDB searchJmolKegDraw
Simcomp SIMCOMP
Class
Antiviral
 DG01656  HIV reverse transcriptase inhibitor
Antineoplastic
 DG01889  Non-nucleoside reverse transcriptase inhibitor
Cyp inducer
 DG01635  CYP3A4 inducer
 DG01897  CYP3A5 inducer
Remark
Same as: 
Therapeutic category: 
ATC code: 
Efficacy
Antiviral, Reverse transcriptase inhibitor
  Disease
HIV-1 infection [DS:H01563]
Comment
Non-nucleoside reverse transcriptase inhibitor (NNRTI)
Target
RNA-directed DNA polymerase
Metabolism
Enzyme: CYP3A4 [HSA:1576], CYP2B6 [HSA:1555], CYP2D6 [HSA:1565]
Interaction
CYP induction: CYP3A4 [HSA:1576], CYP3A5 [HSA:1577], CYP3A7 [HSA:1551], CYP2B6 [HSA:1555]
Drug interaction
Structure map
Anti-HIV agents
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 J ANTIINFECTIVES FOR SYSTEMIC USE
  J05 ANTIVIRALS FOR SYSTEMIC USE
   J05A DIRECT ACTING ANTIVIRALS
    J05AG Non-nucleoside reverse transcriptase inhibitors
     J05AG01 Nevirapine
      D00435  Nevirapine (JAN/USP/INN)
USP drug classification [BR:br08302]
 Antivirals
  Anti-HIV Agents, Non-nucleoside Reverse Transcriptase Inhibitors (NNRTI)
   Nevirapine
    D00435  Nevirapine (JAN/USP/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 6  Agents against pathologic organisms and parasites
  62  Chemotherapeutics
   625  Antivirals
    6250  Antivirals
     D00435  Nevirapine (JAN/USP/INN)
Antiinfectives [BR:br08307]
 Antivirals
  Anti-HIV agents
   Reverse transcriptase inhibitor (RTI)
    Non-nucleoside reverse transcriptase inhibitor (NNRTIs)
     Nevirapine
      D00435  Nevirapine (JAN/USP/INN)
Cytochrome P450 interactions [BR:br08309]
 CYP inducers
  CYP2B6
   Nevirapine
    D00435  Nevirapine (JAN/USP/INN)
  CYP3A4
   Nevirapine
    D00435  Nevirapine (JAN/USP/INN)
  CYP3A5
   Nevirapine
    D00435  Nevirapine (JAN/USP/INN)
  CYP3A7
   Nevirapine
    D00435  Nevirapine (JAN/USP/INN)
Antivirals [br08351.html]
 D00435
New drug approvals in Europe [br08329.html]
 European public assessment reports (EPAR) authorised medicine
  D00435
BRITE hierarchy
Other DBs
CAS: 
129618-40-2
PubChem: 
ChEBI: 
ChEMBL: 
DrugBank: 
PDB-CCD: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        20
            1   C5x C    16.4500  -10.0100
            2   C8y C    15.6100   -8.8900
            3   C8y C    15.9600   -7.5600
            4   N1y N    17.2200   -7.0000
            5   N1x N    17.8500  -10.0100
            6   C8y C    18.4800   -7.6300
            7   C8y C    18.7600   -8.9600
            8   N5x N    14.9100   -6.5800
            9   C8x C    13.5800   -7.0000
            10  C8x C    13.2300   -8.3300
            11  C8x C    14.2800   -9.3100
            12  C8y C    20.0900   -9.3800
            13  C8x C    21.1400   -8.4700
            14  C8x C    20.8600   -7.0700
            15  N5x N    19.5300   -6.6500
            16  O5x O    15.8200  -11.2700
            17  C1y C    17.2200   -5.6000
            18  C1a C    20.3700  -10.7800
            19  C1x C    17.9200   -4.4100
            20  C1x C    16.5200   -4.4100
BOND        23
            1     3   4 1
            2     1   5 1
            3     4   6 1
            4     2   3 1
            5     5   7 1
            6     1   2 1
            7     6   7 1
            8     3   8 2
            9     8   9 1
            10    9  10 2
            11   10  11 1
            12    2  11 2
            13    7  12 2
            14   12  13 1
            15   13  14 2
            16   14  15 1
            17    6  15 2
            18    1  16 2
            19    4  17 1
            20   12  18 1
            21   19  20 1
            22   20  17 1
            23   17  19 1

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