KEGG   DRUG: D00437Help
Entry
D00437                      Drug                                   

Name
Nifedipine (JP16/USP/INN);
Adalat (TN);
Afeditab CR (TN);
Procardia (TN)
Product
  Generic
NIFEDIPINE (A-S Medication Solutions LLC), NIFEDIPINE (Actavis Elizabeth LLC), NIFEDIPINE (Actavis), NIFEDIPINE (Aidarex Pharmaceuticals LLC), NIFEDICALXL (Aidarex Pharmaceuticals LLC), NIFEDICALXL (Aidarex Pharmaceuticals LLC), NIFEDIPINE (Alvogen), NIFEDIPINE (American Health Packaging), NIFEDIPINE (American Health Packaging), NIFEDIPINE (American Health Packaging), AFEDITAB (Aphena Pharma Solutions - Tennessee), NIFEDIPINE (Aphena Pharma Solutions - Tennessee), NIFEDIPINE (AvPAK), NIFEDIPINE (Bryant Ranch Prepack), AFEDITAB (Bryant Ranch Prepack), NIFEDIAC CC (Bryant Ranch Prepack), NIFEDICAL (Bryant Ranch Prepack), NIFEDICAL (Bryant Ranch Prepack), NIFEDICAL (Cardinal Health), NIFEDIPINE (Cardinal Health), NIFEDIPINE (Cardinal Health), NIFEDIPINE (Cardinal Health), AFEDITAB (Carilion Materials Management), NIFEDIPINE (Carilion Materials Management), NIFEDIPINE (Clinical Solutions Wholesale), NIFEDIPINE (Dispensing Solutions), NIFEDIPINE (GAVIS Pharmaceuticals), NIFEDIPINE (Golden State Medical Supply), NIFEDIPINE (Greenstone LLC), NIFEDIPINE (Greenstone LLC), NIFEDIPINE (Heritage Pharmaceuticals), NIFEDIPINE (IVC Industries), NIFEDIPINE (International Labs), NIFEDIPINE (Kremers Urban Pharmaceuticals), NIFEDIPINE (Lake Erie Medical DBA Quality Care Products LLC), NIFEDIPINE (Lake Erie Medical DBA Quality Care Products LLC), NIFEDIPINE (Lake Erie Medical DBA Quality Care Products LLC), NIFEDIPINE (McKesson Packaging Services Business Unit of McKesson Corporation), NIFEDIPINE (McKesson Packaging Servives a business unit of McKesson Corporation), NIFEDIPINE (Mylan Institutional), NIFEDIPINE (Mylan Pharmaceuticals), NIFEDIPINE (Mylan Pharmaceuticals), NIFEDIPINE (NCS HealthCare of KY), NIFEDIPINE (PD-Rx Pharmaceuticals), NIFEDIPINE (PD-Rx Pharmaceuticals), NIFEDIPINE (Par Pharmaceutical), NIFEDIPINE (Par Pharmaceutical), NIFEDIPINE (Par Pharmaceutical), NIFEDIPINE (Physicians Total Care), NIFEDIPINE (Physicians Total Care), NIFEDIPINE (Physicians Total Care), NIFEDIPINE (Preferred Pharmaceuticals), NIFEDIPINE (Preferred Pharmaceuticals), NIFEDIPINE (REMEDYREPACK), NIFEDIPINE (REMEDYREPACK), NIFEDIPINE (REMEDYREPACK), NIFEDIPINE (REMEDYREPACK), NIFEDIPINE (REMEDYREPACK), NIFEDIPINE (Rebel Distributors Corp), NIFEDIPINE (Rebel Distributors Corp), NIFEDIPINE (Rebel Distributors Corp), NIFEDIPINE (Rebel Distributors Corp), NIFEDIPINE (STAT RX USA LLC), NIFEDIPINE (STAT RX USA LLC), NIFEDIPINE (St Marys Medical Park Pharmacy), NIFEDIAC CC (State of Florida DOH Central Pharmacy), NIFEDIPINE (State of Florida DOH Central Pharmacy), NIFEDIPINE (State of Florida DOH Central Pharmacy), NIFEDICAL (State of Florida DOH Central Pharmacy), NIFEDIPINE (State of Florida DOH Central Pharmacy), NIFEDIAC CC (State of Florida DOH Central Pharmacy), NIFEDIPINE (TEVA PHARMACEUTICALS USA), NIFEDIPINE (TEVA PHARMACEUTICALS USA), NIFEDIPINE (TEVA PHARMACEUTICALS USA), NIFEDICAL (Teva Pharmaceuticals USA), NIFEDIPINE (Unit Dose Services), NIFEDIPINE (Unit Dose Services), AFEDITAB (Watson Laboratories), NIFEDIPINE (bryant ranch prepack)
Formula
C17H18N2O6
Exact mass
346.1165
Mol weight
346.3346
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Vasodilator [coronary]
Remark
Same as: 
Therapeutic category: 
ATC code: 
Drug group: 
Comment
Dihydropiridine calcium channel blocker
Target
calcium channel L type blocker [HSA:775 776 778 779] [KO:K04850 K04851 K04853 K04857]
  Pathway
hsa04010  MAPK signaling pathway
hsa04020  Calcium signaling pathway
hsa04260  Cardiac muscle contraction
hsa04270  Vascular smooth muscle contraction  
 
Metabolism
Enzyme: CYP3A4 [HSA:1576], CYP3A5 [HSA:1577]
Interaction
Transporter inhibition: ABCB11 (BSEP) [HSA:8647]
Drug interaction
Structure map
Calcium channel blocking drugs
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 C CARDIOVASCULAR SYSTEM
  C08 CALCIUM CHANNEL BLOCKERS
   C08C SELECTIVE CALCIUM CHANNEL BLOCKERS WITH MAINLY VASCULAR EFFECTS
    C08CA Dihydropyridine derivatives
     C08CA05 Nifedipine
      D00437  Nifedipine (JP16/USP/INN)
USP drug classification [BR:br08302]
 Cardiovascular Agents
  Calcium Channel Blocking Agents
   Nifedipine
    D00437  Nifedipine (JP16/USP/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  21  Cardiovascular agents
   217  Vasodilators
    2171  Coronary dilators
     D00437  Nifedipine (JP16/USP/INN)
Target-based classification of drugs [BR:br08310]
 Ion channels
  Voltage-gated cation channels
   Ca2+ channel, CACN alpha-1, CaVx.x
    calcium channel L type
     Nifedipine
      D00437  Nifedipine (JP16/USP/INN)
Cytochrome P450 interactions [BR:br08309]
 Substrates
  CYP3A4
   Nifedipine
    D00437  Nifedipine (JP16/USP/INN)
  CYP3A5
   Nifedipine
    D00437  Nifedipine (JP16/USP/INN)
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D00437  Nifedipine
  D00437  Nifedipine fine granules
  D00437  Nifedipine extended-release capsules
  D00437  Nifedipine enteric fine granules
BRITE hierarchy
Other DBs
CAS: 
21829-25-4
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        25
            1   C1y C    25.0718  -15.8137
            2   C8y C    25.0602  -18.1895
            3   C2y C    23.9336  -15.1657
            4   C2y C    26.2101  -15.1657
            5   C8y C    23.9161  -18.8492
            6   C8x C    26.1927  -18.8492
            7   C2y C    23.9336  -13.8522
            8   C7a C    22.8010  -15.8137
            9   C2y C    26.2101  -13.8522
            10  C7a C    27.3427  -15.8137
            11  C8x C    23.9161  -20.1509
            12  N2b N    22.7953  -18.1895 #+
            13  C8x C    26.1927  -20.1509
            14  N1x N    25.0718  -13.1984
            15  C1a C    22.8010  -13.1984
            16  O7a O    21.6687  -15.1657
            17  O6a O    22.8070  -17.0279
            18  C1a C    27.3427  -13.1984
            19  O7a O    28.4693  -15.1657
            20  O6a O    27.3427  -17.1271
            21  C8x C    25.0602  -20.8163
            22  O3a O    24.2896  -17.2029
            23  O3a O    20.9448  -19.4212 #-
            24  C1a C    20.5362  -15.8137
            25  C1a C    29.6018  -15.8137
BOND        26
            1     1   2 1
            2     1   3 1
            3     1   4 1
            4     2   5 1
            5     2   6 2
            6     3   7 2
            7     3   8 1
            8     4   9 2
            9     4  10 1
            10    5  11 2
            11    5  12 1
            12    6  13 1
            13    7  14 1
            14    7  15 1
            15    8  16 1
            16    8  17 2
            17    9  18 1
            18   10  19 1
            19   10  20 2
            20   11  21 1
            21   12  22 2
            22   12  23 1
            23   16  24 1
            24   19  25 1
            25    9  14 1
            26   13  21 2

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