KEGG   DRUG: D00440Help
Entry
D00440                      Drug                                   

Name
Nizatidine (JP16/USP/INN);
Acinon (TN);
Axid (TN)
Product
  Generic
Formula
C12H21N5O2S2
Exact mass
331.1137
Mol weight
331.4574
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Anti-ulcerative
Remark
Same as: 
Therapeutic category: 
ATC code: 
Target
H2-receptor antagonist [HSA:3274] [KO:K04150]
  Pathway
hsa04020  Calcium signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04971  Gastric acid secretion  
 
Interaction
Drug interaction
Structure map
Antiulcer drugs
Histamine H2/H3 receptor agonists/antagonists
Brite
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  23  Digestive organ agents
   232  Peptic ulcer agents
    2325  H2 blockers
     D00440  Nizatidine (JP16/USP/INN)
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 A ALIMENTARY TRACT AND METABOLISM
  A02 DRUGS FOR ACID RELATED DISORDERS
   A02B DRUGS FOR PEPTIC ULCER AND GASTRO-OESOPHAGEAL REFLUX DISEASE (GORD)
    A02BA H2-receptor antagonists
     A02BA04 Nizatidine
      D00440  Nizatidine (JP16/USP/INN)
USP drug classification [BR:br08302]
 Gastrointestinal Agents
  Histamine2 (H2) receptor Antagonists
   Nizatidine
    D00440  Nizatidine (JP16/USP/INN)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Histamine
    H2-receptor [HSA:3274] [KO:K04150]
     Nizatidine [ATC:A02BA04]
      D00440  Nizatidine (JP16/USP/INN)
BRITE hierarchy
Other DBs
CAS: 
76963-41-2
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        21
            1   C1b C    21.6127  -25.2508
            2   S2a S    22.8717  -24.5514
            3   C1b C    24.0608  -25.2508
            4   C1b C    25.2498  -24.5514
            5   N1b N    26.5088  -25.2508
            6   C2c C    27.6979  -24.5514
            7   C8y C    20.4236  -24.5514
            8   N5x N    20.4236  -23.1525
            9   C8y C    19.0946  -22.7328
            10  S2x S    18.2553  -23.8519
            11  C8x C    19.0946  -24.9710
            12  C1b C    18.6750  -21.4038
            13  C2b C    28.9569  -25.2508
            14  N1c N    17.3091  -21.1017
            15  C1a C    16.3385  -22.1622
            16  C1a C    16.8910  -19.7792
            17  N2b N    30.1567  -24.5315 #+
            18  O3a O    31.3796  -25.2108
            19  O3a O    30.1338  -23.1526 #-
            20  N1b N    27.7512  -23.1705
            21  C1a C    26.5443  -22.4100
BOND        21
            1     1   2 1
            2     2   3 1
            3     3   4 1
            4     4   5 1
            5     5   6 1
            6     1   7 1
            7     7   8 1
            8     8   9 2
            9     9  10 1
            10   10  11 1
            11    7  11 2
            12    9  12 1
            13    6  13 2
            14   12  14 1
            15   14  15 1
            16   14  16 1
            17   13  17 1
            18   17  18 2
            19   17  19 1
            20    6  20 1
            21   20  21 1

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