KEGG   DRUG: NizatidineHelp
Entry
D00440                      Drug                                   

Name
Nizatidine (JP17/USP/INN);
Acinon (TN);
Axid (TN)
Product
  Generic
NIZATIDINE (A-S Medication Solutions), NIZATIDINE (Actavis Pharma), NIZATIDINE (Amneal Pharmaceuticals LLC), NIZATIDINE (Bryant Ranch Prepack), NIZATIDINE (Bryant Ranch Prepack), NIZATIDINE (Carilion Materials Management), NIZATIDINE (Dispensing Solutions), NIZATIDINE (Dr Reddy's Laboratories Limited), NIZATIDINE (Eon Labs), NIZATIDINE SOLUTION (Gemini Laboratories), NIZATIDINE (Glenmark Generics), NIZATIDINE (H.J. Harkins Company), NIZATIDINE (Lake Erie Medical DBA Quality Care Products LLC), NIZATIDINE (Medsource Pharmaceuticals), NIZATIDINE (Mylan Pharmaceuticals), NIZATIDINE (Preferred Pharmaceuticals), NIZATIDINE (Preferred Pharmaceuticals), NIZATIDINE (Proficient Rx LP), NIZATIDINE (Rebel Distributors Corp), NIZATIDINE (Rebel Distributors Corp), NIZATIDINE (Rebel Distributors Corp), NIZATIDINE (nizatidine)
Formula
C12H21N5O2S2
Exact mass
331.1137
Mol weight
331.4574
Structure
Mol fileKCF fileDB searchJmolKegDraw
Class
Gastrointestinal agent
 DG01481  Histamine receptor H2 antagonist
 DG01975  Agents for peptic ulcer
  DG01481  Histamine receptor H2 antagonist
Remark
Same as: 
Therapeutic category: 
ATC code: 
Activity
Anti-ulcerative, H2 receptor antagonist
Target
HRH2 [HSA:3274] [KO:K04150]
  Pathway
Calcium signaling pathway
Neuroactive ligand-receptor interaction
Gastric acid secretion
Interaction
Drug interaction
Structure map
Antiulcer drugs
Histamine H2/H3 receptor agonists/antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 A ALIMENTARY TRACT AND METABOLISM
  A02 DRUGS FOR ACID RELATED DISORDERS
   A02B DRUGS FOR PEPTIC ULCER AND GASTRO-OESOPHAGEAL REFLUX DISEASE (GORD)
    A02BA H2-receptor antagonists
     A02BA04 Nizatidine
      D00440  Nizatidine (JP17/USP/INN)
USP drug classification [BR:br08302]
 Gastrointestinal Agents
  Histamine2 (H2) receptor Antagonists
   Nizatidine
    D00440  Nizatidine (JP17/USP/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  23  Digestive organ agents
   232  Peptic ulcer agents
    2325  H2 blockers
     D00440  Nizatidine (JP17/USP/INN)
Classification of Japanese OTC drugs [BR:br08313]
 Agents for digestive organs
  09 Histamine H2 receptor blocker containing drugs
   D00440  Nizatidine (JP17/USP/INN)
Risk category of Japanese OTC drugs [BR:br08312]
 First-class OTC drugs
  Inorganic and organic chemicals
   Nizatidine
    D00440  Nizatidine (JP17/USP/INN)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Histamine
    H2-receptor
     Nizatidine
      D00440  Nizatidine (JP17/USP/INN)
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D00440  Nizatidine
  D00440  Nizatidine capsules
Gastrointestinal agents [br08371.html]
 Antiulcer agent
  D00440
Rx-to-OTC switch list in the USA [br08315.html]
 D00440
Rx-to-OTC switch list in Japan [br08314.html]
 D00440
BRITE hierarchy
Other DBs
CAS: 
76963-41-2
PubChem: 
ChEBI: 
ChEMBL: 
DrugBank: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        21
            1   C1b C    21.6127  -25.2508
            2   S2a S    22.8717  -24.5514
            3   C1b C    24.0608  -25.2508
            4   C1b C    25.2498  -24.5514
            5   N1b N    26.5088  -25.2508
            6   C2c C    27.6979  -24.5514
            7   C8y C    20.4236  -24.5514
            8   N5x N    20.4236  -23.1525
            9   C8y C    19.0946  -22.7328
            10  S2x S    18.2553  -23.8519
            11  C8x C    19.0946  -24.9710
            12  C1b C    18.6750  -21.4038
            13  C2b C    28.9569  -25.2508
            14  N1c N    17.3091  -21.1017
            15  C1a C    16.3385  -22.1622
            16  C1a C    16.8910  -19.7792
            17  N2b N    30.1567  -24.5315 #+
            18  O3a O    31.3796  -25.2108
            19  O3a O    30.1338  -23.1526 #-
            20  N1b N    27.7512  -23.1705
            21  C1a C    26.5443  -22.4100
BOND        21
            1     1   2 1
            2     2   3 1
            3     3   4 1
            4     4   5 1
            5     5   6 1
            6     1   7 1
            7     7   8 1
            8     8   9 2
            9     9  10 1
            10   10  11 1
            11    7  11 2
            12    9  12 1
            13    6  13 2
            14   12  14 1
            15   14  15 1
            16   14  16 1
            17   13  17 1
            18   17  18 2
            19   17  19 1
            20    6  20 1
            21   20  21 1

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