KEGG   DRUG: D00443Help
Entry
D00443                      Drug                                   

Name
Spironolactone (JP16/USP/INN);
Aldactone (TN)
Product
  Generic
SPIRONOLACTONE (A-S Medication Solutions LLC), SPIRONOLACTONE (Actavis Elizabeth LLC), SPIRONOLACTONE (Aidarex Pharmaceuticals LLC), SPIRONOLACTONE (American Health Packaging), SPIRONOLACTONE (Amneal Pharmaceuticals), SPIRONOLACTONE (Amneal Pharmaceuticals), SPIRONOLACTONE (AvPAK), SPIRONOLACTONE (Bryant Ranch Prepack), SPIRONOLACTONE (Bryant Ranch Prepack), SPIRONOLACTONE (Bryant Ranch Prepack), SPIRONOLACTONE (Cardinal Health), SPIRONOLACTONE (Cardinal Health), SPIRONOLACTONE (Cardinal Health), SPIRONOLACTONE (Dispensing Solutions), SPIRONOLACTONE (Greenstone LLC), SPIRONOLACTONE (Jubilant Cadista Pharmaceuticals), SPIRONOLACTONE (Lake Erie Medical DBA Quality Care Products LLC), SPIRONOLACTONE (Lake Erie Medical DBA Quality Care Products LLC), SPIRONOLACTONE (Major Pharmaceuticals), SPIRONOLACTONE (McKesson Contract Packaging), SPIRONOLACTONE (McKesson Packaging Services Business Unit of McKesson Corporation), SPIRONOLACTONE (McKesson Packaging Services a business unit of McKesson Corporation), SPIRONOLACTONE (Mutual Pharmaceutical Company), SPIRONOLACTONE (Mylan Pharmaceuticals), SPIRONOLACTONE (NCS HealthCare of KY), SPIRONOLACTONE (PD-Rx Pharmaceuticals), SPIRONOLACTONE (PD-Rx Pharmaceuticals), SPIRONOLACTONE (PD-Rx Pharmaceuticals), SPIRONOLACTONE (Physicians Total Care), SPIRONOLACTONE (Preferred Pharmaceuticals), SPIRONOLACTONE (Preferred Pharmaceuticals), SPIRONOLACTONE (Qualitest Pharmaceuticals), SPIRONOLACTONE (REMEDYREPACK), SPIRONOLACTONE (REMEDYREPACK), SPIRONOLACTONE (REMEDYREPACK), SPIRONOLACTONE (REMEDYREPACK), SPIRONOLACTONE (REMEDYREPACK), SPIRONOLACTONE (REMEDYREPACK), SPIRONOLACTONE (REMEDYREPACK), SPIRONOLACTONE (REMEDYREPACK), SPIRONOLACTONE (Rebel Distributors Corp), SPIRONOLACTONE (Rebel Distributors Corp), SPIRONOLACTONE (Rebel Distributors Corp), SPIRONOLACTONE (Sandoz), SPIRONOLACTONE (St Marys Medical Park Pharmacy), SPIRONOLACTONE (State of Florida DOH Central Pharmacy), SPIRONOLACTONE (State of Florida DOH Central Pharmacy), SPIRONOLACTONE (State of Florida DOH Central Pharmacy), SPIRONOLACTONE (UDL Laboratories), SPIRONOLACTONE (Unit Dose Services), SPIRONOLACTONE (Unit Dose Services), SPIRONOLACTONE (Unit Dose Services)
Formula
C24H32O4S
Exact mass
416.2021
Mol weight
416.5735
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Aldosterone antagonist;
Diuretic
Remark
Same as: 
Therapeutic category: 
ATC code: 
Target
mineralocorticoid receptor antagonist [HSA:4306] [KO:K08555]
  Pathway
hsa04960  Aldosterone-regulated sodium reabsorption  
 
Interaction
Drug interaction
Structure map
Glucocorticoid and meneralocorticoid receptor agonists/antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 C CARDIOVASCULAR SYSTEM
  C03 DIURETICS
   C03D POTASSIUM-SPARING AGENTS
    C03DA Aldosterone antagonists
     C03DA01 Spironolactone
      D00443  Spironolactone (JP16/USP/INN)
USP drug classification [BR:br08302]
 Cardiovascular Agents
  Diuretics, Potassium-sparing
   Spironolactone
    D00443  Spironolactone (JP16/USP/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  21  Cardiovascular agents
   213  Diuretics
    2133  Antialdosterones
     D00443  Spironolactone (JP16/USP/INN)
Target-based classification of drugs [BR:br08310]
 Nuclear receptors
  Estrogen like receptors
   3-Ketosteroid receptor
    mineralocorticoid receptor
     Spironolactone
      D00443  Spironolactone (JP16/USP/INN)
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D00443  Spironolactone
  D00443  Spironolactone tablets
BRITE hierarchy
Other DBs
CAS: 
52-01-7
PubChem: 
DrugBank: 
PDB-CCD: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        29
            1   C1z C    28.2976  -16.1582
            2   C1z C    27.0958  -16.8292
            3   C1x C    29.4642  -16.8582
            4   O7x O    29.4059  -15.3591
            5   C1x C    27.1950  -15.3533
            6   C1y C    27.0784  -18.2059
            7   C1x C    25.9176  -16.1408
            8   C1a C    26.4017  -15.2890
            9   C1x C    29.4468  -18.2292
            10  C7x C    28.9917  -14.0524
            11  C1x C    27.6209  -14.0466
            12  C1y C    25.8942  -18.8825
            13  C1x C    24.7217  -16.8175
            14  O6a O    29.8026  -12.9499
            15  C1y C    24.7100  -18.1883
            16  C1y C    25.8942  -20.2533
            17  C1z C    23.5199  -18.8709
            18  C1x C    24.6983  -20.9417
            19  S2a S    27.0784  -20.9476
            20  C2y C    23.5142  -20.2417
            21  C1x C    22.3300  -18.1825
            22  C1a C    23.5082  -17.4942
            23  C5a C    28.2683  -20.2593
            24  C2x C    22.3300  -20.9359
            25  C1x C    21.1398  -18.8709
            26  C1a C    29.4525  -20.9476
            27  O5a O    28.2743  -18.8825
            28  C5x C    21.1398  -20.2417
            29  O5x O    19.9499  -20.9359
BOND        33
            1     1   2 1
            2     1   3 1
            3     1   4 1 #Up
            4     1   5 1 #Down
            5     2   6 1
            6     2   7 1
            7     2   8 1 #Up
            8     3   9 1
            9     4  10 1
            10    5  11 1
            11    6  12 1
            12    7  13 1
            13   10  14 2
            14   12  15 1
            15   12  16 1
            16   15  17 1
            17   16  18 1
            18   16  19 1 #Down
            19   17  20 1
            20   17  21 1
            21   17  22 1 #Up
            22   19  23 1
            23   20  24 2
            24   21  25 1
            25   23  26 1
            26   23  27 2
            27   24  28 1
            28   28  29 2
            29    6   9 1
            30   10  11 1
            31   13  15 1
            32   18  20 1
            33   25  28 1

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